Results 1 to 10 of about 1,190 (170)

Novel CaLB-like Lipase Found Using ProspectBIO, a Software for Genome-Based Bioprospection [PDF]

BioTech, 2023
Enzymes have been highly demanded in diverse applications such as in the food, pharmaceutical, and industrial fuel sectors. Thus, in silico bioprospecting emerges as an efficient strategy for discovering new enzyme candidates.
Almeida R V, Rafael D Mesquita, Pau Ferrer   +2 more
exaly   +4 more sources

Cell-in-Bead-in-Droplet Platform for pH-Based Microfluidic Screening of Ureolytic Bacteria. [PDF]

Small
Efficient high‐throughput microbial screening in droplet microfluidics is often challenged by chemical crosstalk between droplets. This is particularly difficult in pH‐changing biological processes, for which more effective biochemical assays are needed.
Giovanoli D, Enrriquez N, Kan A, Steinacher M, Buess R, Müller TP, Stavrakis S, deMello A, Studart AR.   +8 more
europepmc   +2 more sources

Antibacterial Evaluation of Tricyclic Antidepressants Against S. aureus and the Possible Pathways of the Mechanism of Action [PDF]

Pathogens
The resistance of Staphylococcus aureus to conventional pharmacological treatments has gradually increased. Thus, new therapeutic strategies are needed.
Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lívia Gurgel do Amaral Valente Sá, Lara Elloyse Almeida Moreira, Cecília Rocha da Silva, João Batista de Andrade Neto, Érica Rayanne Mota da Costa, Thais Lima Ferreira, Leilson Carvalho de Oliveira, Beatriz Oliveira de Souza, Dávylla Rênnia Saldanha Pinheiro, Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior   +14 more
doaj   +2 more sources

Bioprospection and Selection of Peptides by Phage Display as Novel Epitope-Based Diagnostic Probes for Serological Detection of HTLV-1 and Use in Future Vaccines

Frontiers in Medicine, 2022
Human T-lymphotropic virus 1 (HTLV-1) is endemic worldwide and the infection results in severe diseases, including Adult T-cell Leukemia (ATL) and HTLV-1 associated myelopathy (HAM).
Machado Lfa, Ricardo Ishak, Antonio C R Vallinoto   +2 more
exaly   +3 more sources

Antifungal Activity and Possible Mechanism of Action of the Zn (II) Complex With a Schiff Base Against Fluconazole-Resistant Strains of Candida spp. and Cryptococcus neoformans. [PDF]

Chem Biodivers
Addressing the global challenge of antifungal resistance, this work presents a vanillin‐derived Schiff base complexed with zinc (II) (SBZ) with potent activity against fluconazole‐resistant Candida spp. and Cryptococcus neoformans. By activating an apoptotic pathway, ranging from mitochondrial depolarization and oxidative stress to fungal DNA ...
Sá LGDAV, Silva CRD, Neto JBA, Rodrigues DS, Gomes LEAM, Cabral VPF, Silva WMBD, Pinheiro SO, Braga JL, Cavalcanti BC, Moraes MO, Ferreira TL, Lima EA, Oliveira ACM, Júnior HVN.   +14 more
europepmc   +2 more sources

Staphylococcus aureus AgrA Modulators From South African Antimicrobial Plants. [PDF]

Chem Biodivers
The study workflow utilized validated in silico [molecular docking, fingerprinting, pharmacokinetics prediction, molecular dynamics (MD) simulation, ligand‐protein contact maps] tools to bioprospect a wide variety of metabolites surveyed from South African plants with antimicrobial activities, and target them against the key S.
Aruwa CE, Sabiu S.
europepmc   +2 more sources

Bioprospecting Microbial Consortia for Tebuthiuron Degradation in Agricultural Soils: An Alternative Bayesian-Driven Colorimetric Protocol. [PDF]

Environ Microbiol Rep
Microbial consortia from sugarcane soils, particularly ratoon cane environments, showed tebuthiuron‐degrading potential. Bayesian factor estimation of kernel density curves based on logarithmic response ratios enabled interpretation of non‐sigmoidal spectrophotometric data, revealing native microbiota's bioremediation capacity and offering a novel ...
Jorososki LB, Moreira BRA, Cruz VH, Frias YA, Lopes PRM.   +4 more
europepmc   +2 more sources

Polyphasic Characterization of Acetobacter indonesiensis UNPADCC 01-5 Isolated From a Traditional Fermented Food, Oncom Merah. [PDF]

Environ Microbiol Rep
The polyphasic approach (morphology, physiology, biochemistry and genetics) was used to characterize Acetobacter indonesiensis strain UNPADCC 01‐5, which was isolated from oncom merah. The strain's potential as a culture for acidic fermentations and a biofunctional agent was supported by its adaptive characteristics, which included acid tolerance ...
Syaputri Y, Zahra E, Azzahra RN, Annisa, Iswhara DA, Lengkey FO, Fauzia S, Jia X, Wulandari AP, Safitri R.   +9 more
europepmc   +2 more sources

Andrographis paniculata restores gut health by suppressing inflammation and strengthening mucosal immunity [PDF]

Frontiers in Pharmacology
BackgroundGut immunity plays a critical role in overall health by balancing tolerance to food antigens and microbiota while defending against pathogens. Inflammation and infection in the gut can disrupt this balance, leading to disease.
Vidushi Tyagi, Vidushi Tyagi, Ashish Kumar, Karuna Shanker, Anirban Pal, Anirban Pal   +5 more
doaj   +2 more sources

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

Molecules, 2020
The Cactaceae family is an important source of triterpenes and sterols. The wide uses of those plants include food, gathering, medicinal, and live fences. Several studies have led to the isolation and characterization of many bioactive compounds.
Diego Soto-Cabrera, Marco A Loza-Mejía, Juan Rodrigo Salazar   +2 more
exaly   +3 more sources