Results 91 to 100 of about 1,130,205 (306)

Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis

Advanced Science, EarlyView.
Sleep deprivation (SD) exacerbates ligature‐induced periodontitis (LIP) through the trigeminal nerve‐periodontal neuroimmune pathway mediated by the acetylcholinesterase (AChE)‐acetylcholine (ACh)‐α7 nicotinic receptor (α7nAChR) axis. While electroacupuncture (EA) alleviates the condition of LIP combined with SD by activating the α7nAChR.
Kehao Liu, Qi Huang, Mingcong Yang, Ziyu Huang, Kamoran Tuerhong, Yue Zu, Ying Xie, Xuehui Hu, Qianyu Zhang, Ping He, Nannan Huang, Rong Zhang, Yuzhou Li, Sheng Yang   +13 more
wiley   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

Advanced Science, EarlyView.
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia, Xiaoxuan Zhang, Bohang Zhang, Minhui Lu, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha, Yuanjin Zhao, Yan Yuan   +14 more
wiley   +1 more source

Unveiling Macrophage Content as a Predictive Biomarker for Intraoperative ICG Imaging Efficacy in Lung Cancer

Advanced Science, EarlyView.
Indocyanine Green (ICG)‐guided lung cancer surgery efficacy varies significantly among patients. This study identifies tumor macrophage content as a predictive biomarker. Macrophages are primary ICG reservoirs, storing seven‐fold more ICG than cancer cells.
Yue Yan, Jiahui Mi, Yun Li, Guanchao Jiang, Yimeng Zhang, Yanguo Liu, Hui Zhao, Jianfeng Li, Xing Yang, Jun Wang, Fan Yang, Kezhong Chen, Yiguang Wang, Jian Zhou   +13 more
wiley   +1 more source

Ultrasound-Guided Core Needle Biopsy for Salivary Gland Lesions

Gomal Journal of Medical Sciences, 2004
Background: A salivary gland swelling may result from various causes and create a diagnostic challenge. This study was conducted to evaluate the usefulness of ultrasound-guided core needle biopsy as a diagnostic modality.
Syed Qaiser Husain Naqvi, Shamsuddin Shaikh, Syed Qarib Abbas Shah, Jan Muhammad Memon, Anwar Ali Akhund, Tabinda Taqi   +5 more
doaj  

One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids

Advanced Science, EarlyView.
This study presents a one‐step system that delivers different drug doses to brain organoids and monitors their neural activity using integrated 3D microelectrodes. By combining dose‐specific microfluidic delivery with high‐resolution electrophysiological recording, the platform enables simultaneous, real‐time screening of neural responses across ...
Hyogeun Shin, Yeonjoo An, Ju‐Hyun Lee, Ji Hun Kim, Renuka Prasad, Keun‐Tae Kim, Hoon‐Chul Kang, Woong Sun, Seung‐Woo Cho, Il‐Joo Cho   +9 more
wiley   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Comparative analysis of CT guided vertebral biopsy by a conventional bone biopsy needle versus bone biopsy needle with acquisition cradle. [PDF]

J Clin Orthop Trauma, 2021
Singh DK, Boruah T, Sharma A, Khanna G, Krishna LG, Kumar N.   +5 more
europepmc   +1 more source

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

Advanced Science, EarlyView.
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan, Enikő Zakar‐Polyák, Anita Adami, Anna A. Abbas, Yogita Sharma, Raquel Garza, Jenny G. Johansson, Diahann A. M. Atacho, Éva Renner, Miklós Palkovits, Csaba Kerepesi, Johan Jakobsson, Karolina Pircs   +12 more
wiley   +1 more source

Comparative study of bone marrow aspiration and needle biopsy for stainable Iron

مجله دانشگاه علوم پزشکی گرگان, 1999
The amount of stainable Iron in the bone marrow is frequently used as a means of assessing Iron stores. In our study marrow Iron assessed in needle biopsy sections and simultaneously obtained aspirated smears from 75 patients.
Azarhoush R (MD)
doaj