Results 1 to 10 of about 526,733 (120)

Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling

EMBO Molecular Medicine, 2021
Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after AR pathway inhibition (ARPI). We set out to explore poorly defined acute adaptive responses that
Neetu Saxena, Eliana Beraldi, Ladan Fazli, Syam Prakash Somasekharan, Hans Adomat, Fan Zhang, Chidi Molokwu, Anna Gleave, Lucia Nappi, Kimberly Nguyen, Pavn Brar, Nicholas Nikesitch, Yuzhuo Wang, Colin Collins, Poul H Sorensen, Martin Gleave   +15 more
doaj   +1 more source

Translating the prostate cancer survivorship essentials framework into clinical practice: a participatory research process analysis

Cancer Survivorship Research & Care, 2023
Purpose: Accessible cancer survivorship care is a key tenet of quality cancer care. However, prostate cancer survivorship care is often fragmented with best practice models of care largely undefined. The Prostate Cancer Survivorship Essentials Framework (
Nicole Heneka, Helen Crowe, Suzanne K. Chambers, Anthony Costello, Jane Crowe, Phil Dundee, Rachel Heerey, Elles Stijnen, Chris Bolger, Isabelle Schaefer, Jeff Dunn   +10 more
doaj   +1 more source

Examining the influence of illness perception and financial toxicity on the quality of life of prostate cancer patients

African Journal of Urology, 2021
Background Cancer of the prostate (CaP) is a public health problem that affects the male genitourinary system causing a significant threat to men’s quality of life (QoL).
Elizabeth O. Akin-Odanye, Chidiebere N. Ogo, Faoziyat A. Sulaiman, Lawal Suleiman, Motolani E. Ogunsanya, Folakemi T. Odedina   +5 more
doaj   +1 more source

Dependency of Tamoxifen Sensitive and Resistant ER⁺ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth

Cells, 2023
Estrogen receptor positive (ER+) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the ...
Satyam Bhasin, Christopher Dusek, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin Gleave, Christopher J. Ong   +6 more
doaj   +1 more source

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

Genome Medicine, 2019
Background Malignant peritoneal mesothelioma (PeM) is a rare and fatal cancer that originates from the peritoneal lining of the abdomen. Standard treatment of PeM is limited to cytoreductive surgery and/or chemotherapy, and no effective targeted ...
Raunak Shrestha, Noushin Nabavi, Yen-Yi Lin, Fan Mo, Shawn Anderson, Stanislav Volik, Hans H. Adomat, Dong Lin, Hui Xue, Xin Dong, Robert Shukin, Robert H. Bell, Brian McConeghy, Anne Haegert, Sonal Brahmbhatt, Estelle Li, Htoo Zarni Oo, Antonio Hurtado-Coll, Ladan Fazli, Joshua Zhou, Yarrow McConnell, Andrea McCart, Andrew Lowy, Gregg B. Morin, Tianhui Chen, Mads Daugaard, S. Cenk Sahinalp, Faraz Hach, Stephane Le Bihan, Martin E. Gleave, Yuzhuo Wang, Andrew Churg, Colin C. Collins   +32 more
doaj   +1 more source

The diagnostic accuracy of multiparametric MRI for detection and localization of prostate cancer depends on the affected region

BJUI Compass, 2021
Objectives To determine the diagnostic accuracy of 3T multiparametric magnetic resonance imaging (mpMRI) for detecting and locating prostate cancer (PCa) on Dickinson's 27‐sector map, using histopathology specimens from radical prostatectomy (RP) as the ...
Martina Martins, Stefano Regusci, Stephane Rohner, Ildiko Szalay‐Quinodoz, Georges‐Antoine De Boccard, Louise Strom, Gerjon Hannink, Sonia Ramos‐Pascual, Charles Henry Rochat   +8 more
doaj   +1 more source

SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1

EMBO Molecular Medicine, 2018
Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways.
James W Peacock, Ario Takeuchi, Norihiro Hayashi, Liangliang Liu, Kevin J Tam, Nader Al Nakouzi, Nastaran Khazamipour, Tabitha Tombe, Takashi Dejima, Kevin CK Lee, Masaki Shiota, Daksh Thaper, Wilson CW Lee, Daniel HF Hui, Hidetoshi Kuruma, Larissa Ivanova, Parvin Yenki, Ivy ZF Jiao, Shahram Khosravi, Alice L‐F Mui, Ladan Fazli, Amina Zoubeidi, Mads Daugaard, Martin E Gleave, Christopher J Ong   +24 more
doaj   +1 more source

The relationship between biochemical recurrence and number of lymph nodes removed during surgery for localized prostate cancer

BMC Urology, 2023
Purpose To assess whether completeness of pelvic lymph node dissection (PLND) as measured by lymph node yield reduces biochemical recurrence (BCR) in men undergoing radical prostatectomy (RP) for prostate cancer (PCa), stratified according to Briganti ...
Paul Doan, Athos Katelaris, Matthijs J. Scheltema, Andrew Hayen, Amer Amin, Amila Siriwardana, Minh Tran, Bart Geboers, William Gondoputro, Anne Maree Haynes, Jayne Matthews, Warick Delprado, Phillip D. Stricker, James Thompson   +13 more
doaj   +1 more source

Initial Longitudinal Outcomes of Risk-Stratified Men in Their Forties Screened for Prostate Cancer Following Implementation of a Baseline Prostate-Specific Antigen

The World Journal of Men's Health, 2023
Purpose: Prostate cancer (PCa) screening can lead to potential over-diagnosis/over-treatment of indolent cancers. There is a need to optimize practices to better risk-stratify patients.
Zoe D. Michael, Srinath Kotamarti, Rohith Arcot, Kostantinos Morris, Anand Shah, John Anderson, Andrew J. Armstrong, Rajan T. Gupta, Steven Patierno, Nadine J. Barrett, Daniel J. George, Glenn M. Preminger, Judd W. Moul, Kevin C. Oeffinger, Kevin Shah, Thomas J. Polascik   +15 more
doaj   +1 more source

Cellular Adaptation to VEGF-Targeted Antiangiogenic Therapy Induces Evasive Resistance by Overproduction of Alternative Endothelial Cell Growth Factors in Renal Cell Carcinoma

Neoplasia: An International Journal for Oncology Research, 2015
Vascular endothelial growth factor (VEGF)–targeted antiangiogenic therapy significantly inhibits the growth of clear cell renal cell carcinoma (RCC).
Kyung Seok Han, Peter A. Raven, Sebastian Frees, Kilian Gust, Ladan Fazli, Susan Ettinger, Sung Joon Hong, Cristian Kollmannsberger, Martin E. Gleave, Alan I. So   +9 more
doaj   +1 more source