Results 31 to 40 of about 837,272 (256)

Protocol for the P3BEP trial (ANZUP 1302): an international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours

BMC Cancer, 2018
Background Bleomycin, etoposide, and cisplatin (BEP) chemotherapy administered every 3 weeks for 4 cycles remains the standard first line treatment for patients with intermediate- and poor-risk metastatic germ cell tumours (GCTs).
Nicola J. Lawrence, Howard Chan, Guy Toner, Martin R. Stockler, Andrew Martin, Sonia Yip, Nicole Wong, Annie Yeung, Danish Mazhar, Farzana Pashankar, Lindsay Frazier, Ray McDermott, Roderick Walker, Hsiang Tan, Ian D. Davis, Peter Grimison, on behalf of ANZUP   +16 more
doaj   +1 more source

Two-year quality of life after robot-assisted radical prostatectomy according to pentafecta criteria and cancer of the prostate risk assessment (CAPRA-S)

Scientific Reports, 2022
The quality of life (QoL) of men with optimal outcomes after robot-assisted radical prostatectomy (RARP) is largely unexplored. Thus we assessed meaningful changes of QoL measured with the EORTC QLQ-C30 24 months after RARP according to postsurgical ...
Theodoros Karagiotis, Jorn H. Witt, Thomas Jankowski, Mikolaj Mendrek, Christian Wagner, Andreas Schuette, Nikolaos Liakos, Pawel Rachubinski, Katarina Urbanova, Matthias Oelke, Mykyta Kachanov, Sami-Ramzi Leyh-Bannurah   +11 more
doaj   +1 more source

Long-term outcome among men with conservatively treated localised prostate cancer. [PDF]

, 2006
Optimal management of clinically localised prostate cancer presents unique challenges, because of its highly variable and often indolent natural history.
Kattan, M W, Oliver, T, M W Kattan, Scardino, P, V Reuter, H Møller, J Eastham, Cuzick, J, Reuter, V, D Berney, Fearn, P, P Fearn, Berney, D, J Cuzick, Moller, H; id_orcid, Eastham, J, Foster, C S, Transatlantic Prostate Group, P Scardino, Fisher, G, Foster, CS, Møller, H, G Fisher, C S Foster, Kattan, MW, T Oliver   +25 more
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Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort. [PDF]

, 2012
BACKGROUND: The natural history of prostate cancer is highly variable and it is difficult to predict. We showed previously that a cell cycle progression (CCP) score was a robust predictor of outcome in a conservatively managed cohort diagnosed by ...
Younus, A, Stone, S, M Perry, Mesher, D, A Gutin, J S Lanchbury, Scardino, P, H Møller, A Younus, Gutin, A., J Park, Stone, S., Cuzick, J, D M Berney, Lanchbury, JS, D Mesher, Scardino, P., Mesher, D., J Cuzick, Berney, D. M., Moller, H.; id_orcid, Cuzick, J., Reid, JE, Lanchbury, J. S., Berney, DM, Fisher, G., Perry, M, Transatlantic Prostate Group, P Scardino, S Stone, Foster, C. S., Fisher, G, Møller, H, Foster, CS, Reid, J. E., G Fisher, C S Foster, Younus, A., J E Reid, Park, J., Gutin, A, Park, J, Perry, M.   +42 more
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Salvage robot-assisted radical prostatectomy following focal ablation with irreversible electroporation: feasibility, oncological and functional outcomes

BMC Urology, 2022
Background To report the feasibility, oncological and functional outcomes of salvage robot-assisted radical prostatectomy (sRARP) for recurrent prostate cancer (PCa) after irreversible electroporation (IRE).
Alexandar Blazevski, William Gondoputro, Matthijs J. Scheltema, Amer Amin, Bart Geboers, Daniela Barreto, Anne-Maree Haynes, Ron Shnier, Warick Delprado, Shikha Agrawal, James E. Thompson, Phillip D. Stricker   +11 more
doaj   +1 more source

Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study. [PDF]

, 2009
Treatment decisions after diagnosis of clinically localised prostate cancer are difficult due to variability in tumour behaviour. We therefore examined one of the most promising biomarkers in prostate cancer, Ki-67, in a cohort of 808 patients diagnosed ...
A Gopalan, M W Kattan, Scardino, P, V Reuter, C Cooper, J Eastham, Eastham, J., Gopalan, A., Cuzick, J, Gerald, W., Gopalan, A, Reuter, V, Ambroisine, L., D M Berney, Kudahetti, S., H Moller, Scardino, P., Reuter, V., Kudahetti, S, Moller, H, Gerald, W, J Cuzick, Berney, D. M., Moller, H.; id_orcid, Møller, H., Cuzick, J., Berney, DM, L Ambroisine, Fisher, G., Eastham, J, Cooper, C., S Kudahetti, P Scardino, Ambroisine, L, Foster, C. S., Fisher, G, Foster, CS, Cooper, C, W Gerald, G Fisher, C S Foster, Kattan, M. W., Kattan, MW   +42 more
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Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate [PDF]

, 2011
Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction.
Goettinger, Johanna, Martin Hennenberg, Christian G. Stief, Petter Hedlund, Göttinger, Johanna,, Stief, Christian G., Christian Gratzke, Andersson, Karl-Erik, Reich, Oliver,, Reich, Oliver, Johanna Göttinger, Stief, Christian G.,, Schlenker, Boris,, Bauer, Ricarda M.,, Hedlund, Petter,, Andersson, Karl-Erik,, Strittmatter, Frank, Hennenberg, Martin,, Bauer, Ricarda M., Oliver Reich, Gratzke, Christian,, Ricarda M. Bauer, Hedlund, Petter, Frank Strittmatter, Karl-Erik Andersson, Gratzke, Christian, Hennenberg, Martin, Strittmatter, Frank,, Schlenker, Boris, Boris Schlenker   +29 more
core   +1 more source

A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes

npj Precision Oncology, 2023
Specific classes of DNA damage repair (DDR) defect can drive sensitivity to emerging therapies for metastatic prostate cancer. However, biomarker approaches based on DDR gene sequencing do not accurately predict DDR deficiency or treatment benefit ...
Elie J. Ritch, Cameron Herberts, Evan W. Warner, Sarah W. S. Ng, Edmond M. Kwan, Jack V. W. Bacon, Cecily Q. Bernales, Elena Schönlau, Nicolette M. Fonseca, Veda N. Giri, Corinne Maurice-Dror, Gillian Vandekerkhove, Steven J. M. Jones, Kim N. Chi, Alexander W. Wyatt   +14 more
doaj   +1 more source

Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]

, 2010
Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Travis Jerde, Wade Bushman, Travis J. Jerde, Zhong Wu, Dan Theodorescu   +4 more
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Finasteride Upregulates Expression of Androgen Receptor in Hyperplastic Prostate and Lncap Cells: Implications for Chemoprevention of Prostate Cancer

, 2012
BACKGROUND: Although finasteride is recognized for its role as a chemopreventive agent for prostate cancer, higher grades of malignancy have been reported.
謝汝敦;陳世乾;余宏政;張宏江, HSIEH, JU-TON;CHEN, SHYH-CHYAN;YU, HONG-JENG;CHANG, HONG-CHIANG   +1 more
core   +1 more source