Results 191 to 200 of about 121,435 (266)

Diagnostic Value of Micro‐Ultrasound in Identifying Local Recurrence After Radical Prostatectomy

open access: yesThe Prostate, EarlyView.
ABSTRACT Purpose The limited resolution of standard transrectal ultrasound (TRUS) has made it difficult to perform biopsies of the prostate bed in cases of suspected local recurrence following radical prostatectomy. The aim of this study was to benchmark the performance of using high resolution micro‐ultrasound (microUS) in place of standard TRUS for ...
Basil Kaufmann   +11 more
wiley   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins   +6 more
wiley   +1 more source

Targeted Nanocomplex Delivery for Protecting Vascular Integrity and Enhancing Anticancer Effects in Hepatocellular Carcinoma

open access: yesSmall Science, EarlyView.
Herein, a liver‐targeted nanohybrid formulation, SGLC/DOX@AG, is developed to enhance doxorubicin delivery and reduce vascular toxicity in hepatocellular carcinoma (HCC) treatment. Incorporating an albumin–glucosamine lipid complex, the system shows potent anticancer effects and minimized side effects across in vitro, in vivo, and cancer‐on‐a‐chip ...
Hyelim Kim   +11 more
wiley   +1 more source

Near‐Infrared‐Triggered Nanodroplets for Imaging‐Guided Macrophage‐Mediated Cancer Immunotherapy

open access: yesSmall Methods, EarlyView.
Schematic illustration of the Nanodroplets and their theranostics application–The engineered nanodroplets integrate a multifunctional design, encapsulating the immunostimulant resiquimod (R848), indocyanine green (ICG), and volatile perfluoropentane (PFP), within a biocompatible double‐emulsion structure.
Junxi Yi   +3 more
wiley   +1 more source

Engineering Pt Single‐Atom Doped SeS2/Ti3CNTx MXene with Molecularly Imprinted Polymer for Precision Pancreatic Cancer Diagnostics: DFT and Molecular Dynamics Perspectives

open access: yesSmall Methods, EarlyView.
A novel approach is developed to pancreatic cancer screening by targeting the cyclophili‐B (CypB)protein using a molecularly imprinted polymer with the electrode material containing Pt single‐atom‐doped/SeS2‐Ti3CNTx MXene. The quantification of CypB in pancreatic cancer tissues provide an insight into the association of CypB with pancreatic cancer ...
Sathish Panneer Selvam   +3 more
wiley   +1 more source

Flexible Cervical Photodynamic Therapy Device

open access: yesTranslational Biophotonics, EarlyView.
This paper aims to design a flexible photodynamic therapy device for the cervix and cervical vault, using an LED array, light guide, and flexible trumpet‐shaped homogenizer. Simulations and tests show output irradiance up to 98 mW/cm2 with < 14.2% variation, offering a low‐cost solution for cervical cancer and precancerous lesions.
Teng Jin   +5 more
wiley   +1 more source

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