Results 331 to 340 of about 2,118,431 (433)

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

open access: yesAdvanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li   +3 more
wiley   +1 more source

Surface area outcomes in EUS-guided liver biopsy: a comparative study of Franseen and Fork-tip needles. [PDF]

open access: yesBMC Gastroenterol
Matsumoto K   +8 more
europepmc   +1 more source

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

open access: yesAdvanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian   +10 more
wiley   +1 more source

Liquid biopsy in gynecological cancers: a translational framework from molecular insights to precision oncology and clinical practice. [PDF]

open access: yesJ Exp Clin Cancer Res
Martinelli C   +23 more
europepmc   +1 more source

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

open access: yesAdvanced Science, EarlyView.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang   +11 more
wiley   +1 more source

Enhancing Prostate Cancer Diagnosis: A Comparative Analysis of Combined Fusion and Systematic Biopsy Methods-A Single-Center Study. [PDF]

open access: yesJ Clin Med
Kania E   +7 more
europepmc   +1 more source

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

open access: yesAdvanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini   +8 more
wiley   +1 more source

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