Results 71 to 80 of about 46,659 (254)
Advanced Science, EarlyView.Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng +17 more
wiley +1 more source
Scale-down bioreactors—comparative analysis of configurations
In large-scale bioprocesses, gradients in pH, dissolved oxygen level (DO), and substrate concentrations can decrease bioprocess efficiency. Scale-down bioreactors, be it single stirred-tank bioreactors with a special feeding regime, multi-compartment ...
Lievonen, Anni Elina +5 more
core +1 more source
Bioreactors for tissue engineering
, 2009 [[abstract]]c2006 Springer - Bioreactors are essential in tissue engineering, not only because they provide an in vitro environment mimicking in vivo conditions for the growth of tissue substitutes, but also because they enable systematic studies of the ...
Chen, Huang-Chi;Hu, Yu-Chen
core +1 more source
Advanced Science, EarlyView.ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan +5 more
wiley +1 more source
Bioreactors in coffee micropropagation
, 2006 In coffee, bioreactors are the most promising way for scaling-up micropropagation processes, particularly somatic embryogenesis. The availability of an efficient somatic embryogenesis process would allow the rapid mass production of heterozygous ...
Bertrand, Benoît +3 more
core
Nutrient transport in bioreactors for bone tissue growth : why do hollow fiber membrane bioreactors work [PDF]
, 2009 One of the main aims of bone tissue engineering is to produce three-dimensional soft bone tissue constructs of acceptable clinical size and shape in bioreactors.
Diganta Das (1254000) +2 more
core
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Angewandte Chemie, EarlyView.This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis +2 more
wiley +2 more sources
3D microfabricated bioreactors
, 2006 We present here an innovative three dimensional microfabrication technology coupled with mass transport simulation to enable the design and fabrication of advanced microbioreactors.
Sun, C. +4 more
core
Monitoring Bioreactors Using Improved Techniques
, 2018 Woodchip bioreactors are an effective tool for reducing nitrate in tile drainage leaving farm fields. Bioreactors are a recognized tool in the Iowa Nutrient Reduction Strategy to reduce total nitrogen loads by 45 percent.
Ray, Caleb +4 more
core +1 more source