Results 151 to 160 of about 39,038 (300)

A continuous‐time random encounter and staying time (REST) model: Moving beyond temporal aggregation in camera‐trap density estimation

open access: yesMethods in Ecology and Evolution, EarlyView.
Abstract Estimating wildlife population density is fundamental to ecology and conservation. While camera traps have revolutionized the monitoring of medium‐ to large‐sized mammals, estimating the density of unmarked populations remains a major challenge. Current models rely on a critical and often‐violated synchronized activity assumption.
Ryo Matsuoka   +2 more
wiley   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

open access: yesAndrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu   +2 more
wiley   +1 more source

Oxalis pes-caprae L. (Oxalidaceae): From Invasive Concern to Promising Bioresource for Health and Sustainable Applications

open access: yes
Oxalis pes-caprae L., an invasive plant from South Africa, has developed into a severe ecological threat in many Mediterranean and temperate areas by replacing native flora and modifying ecosystems.
Giuseppe Antonio Malfa   +5 more
core   +1 more source

Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice

open access: yesAndrology, EarlyView.
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda   +2 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof   +8 more
wiley   +1 more source

Triple‐Mutated HSV‐1 Expressing Soluble B7‐1 Plus CTLA‐4 Blockade Suppresses Lymph Node Metastasis in Tongue Cancer

open access: yesCancer Science, EarlyView.
In murine tongue cancer models, T‐mB7‐1, a triple‐mutated oncolytic herpes simplex virus type 1 (HSV‐1) engineered to express soluble B7‐1, suppresses cervical lymph node metastasis and improves survival, addressing a major prognostic determinant in oral squamous cell carcinoma (OSCC).
Akinari Sugauchi   +11 more
wiley   +1 more source

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