Results 201 to 210 of about 2,382,076 (302)

Hyperthermia‐induced cytotoxicity and modulation of PD‐L1 and MHC‐I expression in human non‐small cell lung cancer cell lines

open access: yesExperimental Physiology, EarlyView.
Abstract Hyperthermia has recently been applied to treat human non‐small cell lung cancer (NSCLC). However, the mechanisms underlying cytotoxic sensitivity of NSCLC cells to hyperthermia are not fully understood. In this study, five NSCLC cell lines with different epidermal growth factor receptor (EGFR), Kirsten rat sarcoma and tumor protein p53 ...
Yun‐Chieh Tu   +10 more
wiley   +1 more source

MoG+3.0: expanded structural variant visualization and integration of genomic data from five newly analyzed mouse strains. [PDF]

open access: yesMamm Genome
Takada T   +7 more
europepmc   +1 more source

High‐Efficiency Genome Editing of Chlorella sp. by CRISPR/Cas9

open access: yes
Plant Biotechnology Journal, EarlyView.
Xinyu Cui   +5 more
wiley   +1 more source

Impact of long‐term maternal high‐fat, high‐sugar feeding on gastric vagal afferent responses and feeding behaviour in mouse offspring

open access: yesExperimental Physiology, EarlyView.
Abstract Poor maternal nutrition and excessive gestational weight gain predict future development of obesity in offspring. Preclinically, maternal obesity induced by a high‐fat, high‐sugar diet (HFHSD) induces hyperphagia and obesity in offspring. We hypothesized that this might, in part, reflect reduced peripheral gastric vagal afferent (GVA) satiety ...
Georgia S. Clarke   +7 more
wiley   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

open access: yesExperimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela   +4 more
wiley   +1 more source

Cell biology of Dictyostelium. [PDF]

open access: yesBMC Mol Cell Biol
Huber RJ, Steimle PA, Damer CK.
europepmc   +1 more source

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

open access: yesInternational Journal of Cancer, Volume 158, Issue 6, Page 1740-1754, 15 March 2026.
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta   +10 more
wiley   +1 more source

Wogonoside Modulates the Nrf2/SLC40A1 Signaling Axis to Combat Inflammatory Osteolysis

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
This study explores the potential of wogonoside, a flavonoid from Scutellaria baicalensis, for treating inflammatory osteolysis and provides compelling experimental evidence supporting its promise as a functional food ingredient to alleviate associated bone loss.
Siyuan Zhou   +6 more
wiley   +1 more source

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