Results 161 to 170 of about 46,946 (304)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Erratum: Effector-Triggered Immunity Is a Key Component of Nonhost Resistance in Nicotiana benthamiana against the Rice Blast Pathogen Magnaporthe oryzae. [PDF]

Plant Pathol J
Kim J, Lee S, Seo MK, Byun D, Chae E, Park E, Choi D.   +6 more
europepmc   +1 more source

Nanosensors based on lignocellulosic materials

In recent years, lignocellulosic materials have become regarded as attractive and noteworthy natural resources owing to their renewability, recyclability, easy processability, abundance, biodegradability, and low cost.
Oncul, Bartu, Dalkilic, Berk, Candan, Zeki, Durmaz, Ekrem   +3 more
core   +1 more source

Triple‐Mutated HSV‐1 Expressing Soluble B7‐1 Plus CTLA‐4 Blockade Suppresses Lymph Node Metastasis in Tongue Cancer

Cancer Science, EarlyView.
In murine tongue cancer models, T‐mB7‐1, a triple‐mutated oncolytic herpes simplex virus type 1 (HSV‐1) engineered to express soluble B7‐1, suppresses cervical lymph node metastasis and improves survival, addressing a major prognostic determinant in oral squamous cell carcinoma (OSCC).
Akinari Sugauchi, Toshihiro Uchihashi, Hirotaka Ito, Miwako Iwai, Yuzuri Tsurumaki Sato, Kyoko Kurioka, Sena Zeynep Usta, Minoru Tanaka, Mikihiko Kogo, Susumu Tanaka, Hiroshi Fukuhara, Tomoki Todo   +11 more
wiley   +1 more source

DockingDB: An online reverse-docking database for plant hormone research. [PDF]

Plant Commun
Guo YX, Liu F, Xu XD, Xu G, Ye SY, Shao YH, Kong Y, Su Z, Zhao Q, Fu Q, Ma J, Song JM, Cai W, Ming Z, Chen LL.   +14 more
europepmc   +1 more source

Effects of adding Fe2O3 and Fe3O4 nanoparticles to soil on germination and seedling characteristics of Oriental beech

Effects of Fe-based nanoparticles (Fe2O3 and Fe3O4) on germination parameters were studied for some seedling characteristics of Oriental beech (Fagus orientalis) seeds.
Özel, Handan Ucun, Özel, Halil Barış, Yıldız, Yafes, Sevik, Hakan   +3 more
core   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

Correction: Study of grapevine endophytes' interaction with the host and their potential as biocontrol agents as sustainable alternative to agrochemicals. [PDF]

Front Microbiol
Pizzi S, Canito AD, Mulero EP, Bezerra CCON, Ricciardi V, Maddalena G, Maluleke E, Foschino RC, Toffolatti SL, Fracassetti D, Lorenzis G, Cordero-Bueso G, Setati ME, Vigentini I.   +13 more
europepmc   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Abstract Book of: The first International Seminar on Bioresources, Nutrition, and Health (ISBNH, 2022)

Revue Nature et Technologie
The first International Seminar on Bioresources, Nutrition, and Health (ISBNH, 2022) took place in Mostaganem, Algeria, from November 28th to 29th, 2022. The ISBNH 2022 comprised of 100% video conferencing and a one-line seminar organized around four
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