Results 161 to 170 of about 117,129 (304)

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Synthetic Mirror Bacteria as a Frontier for Chiral Synthetic Biology and Biocontainment. [PDF]

Microbiologyopen
Bhuiyan MNI.
europepmc   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

A multi-method integrated weighting framework for biosafety risk assessment of infectious substances. [PDF]

Sci Rep
Wu F, Li C, Bian Y, Li J, Tian J, Li Z.
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Co-Culture Systems to Study Epithelial-Immune Interactions During SARS-CoV-2 Infection. [PDF]

Curr Protoc
Randell SH, Barnett KC.
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Biosafety Management Based Upon Risk Assessment and Monitoring: Perspectives from a Clinical Laboratory, China

Qizhi Diao,1 Yongpei Long,2 Fangyu Yang,3 Cuihui Nong,1 Huamiao Tang,1 Xiangmin Zhou,1 Guoqiang Zhu,4 Qiang Ding5 1Hainan Branch, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, People’s Republic of China ...
Nong C, Long Y, Diao Q, Zhu G, Ding Q, Zhou X, Yang F, Tang H   +7 more
core   +1 more source

APHL Biosafety Checklist [PDF]

There is an inherent risk in a laboratory handling any infectious agents. Biosafety practices should be adhered to in all laboratories that receive potentially infectious material in order to ensure laboratory personnel, public and environmental safety ...

core  

Can a mosquito-borne virus become a cancer therapy? rethinking Getah virus through the lens of oncolytic virotherapy. [PDF]

Front Cell Infect Microbiol
Efa BB, Antwi-Osei Jnr J.
europepmc   +1 more source