Results 221 to 230 of about 132,140 (253)

What goes around comes around: updates in the study of <i>Coxiella burnetii</i> lipopolysaccharide phase variation. [PDF]

Infect Immun
Pierce KN, Anderson R, Brose M, McCormick-Ell J, Long CM.   +4 more
europepmc   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

A semi-quantitative risk assessment of pathogenic microorganism laboratories in Beijing's CDCs based on a three-dimensional risk matrix model. [PDF]

Biosaf Health
Fu Y, Mu X, Xu X, Wang X, Lin C, Li J, Chen M.   +6 more
europepmc   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

How to Perform a Tracer Displacement BRET Assay for the TRPML1 Ion Channel. [PDF]

Bio Protoc
Cunha MR, Catta-Preta CMC, Massirer KB, Couñago RM.   +3 more
europepmc   +1 more source

Non‐Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice

Advanced Science, EarlyView.
Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li, Hongzheng Lin, Sheng Yu, Yunhui Liao, Teng Huang, Zeyu Xiao, Wei Lu   +6 more
wiley   +1 more source

Correction: integrated multi-omics strategy for screening novel protective antigens against Brucella melitensis and analysis of their immunogenicity. [PDF]

Braz J Microbiol
Dong Z, Li S, Guo J, Bao L.
europepmc   +1 more source

Rethinking governance of synthetic cells. [PDF]

Front Bioeng Biotechnol
Gillum DR, Carr PA, Hook-Barnard I, Tucholski T.   +3 more
europepmc   +1 more source

China's regulatory regime for medical biotechnology: evolution, challenges, and future perspectives. [PDF]

Front Med Technol
Zhang E.
europepmc   +1 more source