Results 241 to 250 of about 162,481 (277)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Single-Cell Transcriptome Profiling Reveals the Immune Dysregulation Characteristics of Mice Infected With Brucella abortus. [PDF]

J Infect Dis
Zhang G, Shen Q, Ye J, Feng Y, Boireau P, Fan X, Lv L, Li Y, Xu X, Cha H, Shen C, Zhang Y, Peng X, Jiang H, Ding J.   +14 more
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

The role, challenges, and solutions of laboratories in disaster medicine: a systematic review. [PDF]

Front Public Health
Tran KT, Nguyen KD, Nguyen TN, Pham LT, Nguyen LM, Nguyen PH, Tran NH, Le CTK.   +7 more
europepmc   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Optimised Neutralisation Strategies for Validating the Virucidal Efficacy of Micro-Chem Plus™ Against High-Containment Negative-Sense RNA Viruses. [PDF]

Viruses
Gao X, Peng C, Shan C, Yao Y, Yuan Z.
europepmc   +1 more source

Mining and quantitative evaluation of the laboratory biosafety policy in China. [PDF]

PLoS One
Xiang C, Zhu Q, Wen J, Xie L, Hao R, Qiu X, Zhu F.   +6 more
europepmc   +1 more source

Corrigendum to "Isolation and characterization of a novel coltivirus from <i>Haemaphysalis concinna</i> ticks in Northeastern China" [Infectious Medicine 4 (2025) 100179]. [PDF]

Infect Med (Beijing)
Yang YH, Li JX, Wang RC, Yin QK, Fu SH, Nie K, Cui QQ, Xu ST, Wei Q, Li F, Li XZ, Wang HY.   +11 more
europepmc   +1 more source

Publisher Correction: The role of 2ʹ–5ʹ-oligoadenylate synthase-like protein (OASL1) in biliary and hepatotoxin-induced liver injury in mice

Scientific Reports
Mwense Leya, Daram Yang, Tien Huyen Ton Nu Bao, Hyuneui Jeong, Sang‑Ik Oh, Jong‑Hoon Kim, Jong‑Won Kim, Bumseok Kim   +7 more
doaj   +1 more source