Results 151 to 160 of about 20,909 (242)

EDUCATIONAL DISCIPLINE "BIOSAFETY AND BIOETHICS" IN PROVIDING THE PROFESSIONALISM OF BIOTECHNOLOGIST STUDENTS

Bulletin of Problems Biology and Medicine
M. M. Lisovyy, Yu. V. Kolomiiets, O. E. Dmytrieva, R. P. Tsurkan   +3 more
openaire   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Building a One Health mobile laboratory workforce: strengthening public health preparedness across Europe and Africa. [PDF]

Hum Resour Health
Melo AM, Becker-Ziaja B, Keller M, Sangale D, Puradiredja DI, Habermann T, Bönecke J, Tomazatos A, Peham JR, Michalek B, Aasamäe A, Duscher GG, Winkelmayer L, Framke D, Schranz MT, Gleißner D, Groschup M, Haghighi F, Slowikowski P, Schwabe K, Politi L, Mellou K, Flountzi A, Dimitriadou D, Spiliopoulou I, Spanakos G, Varela A, Libenaga R, Beda M, Mgimba E, Ugolole A, Rashidi J, Munga A, Kagaruki P, Motto S, Mwafulango A, Moremi N, Mkama P, May J, Affara M, Gehre F.   +40 more
europepmc   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Academic-practice partnerships in public health workforce development in China: a comparative analysis of 12 purposively selected cases. [PDF]

Front Public Health
Li W, Ren Y, Fan Z, Zhu L, Ma G.
europepmc   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Correction: Genome-wide characterization of the tomato UDP-glycosyltransferase gene family and functional identification of SlUDPGT52 in drought tolerance

Horticulture Advances
Ling Qiu, Xingyu Chen, Huifang Hou, Yuxuan Fan, Lulu Wang, Haiyue Zeng, Xueting Chen, Yin Ding, Xiaomeng Hu, Qingxia Yan, Huihui Ma, Jinhua Li   +11 more
doaj   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

A practical low-cost course module for teaching bacteriophage isolation to undergraduate students. [PDF]

J Microbiol Biol Educ
Coelho LFL, Amaral RP, Terceti MdS, Santos ALCd, Aio BRF, Carvalho BAd, Malaquias LCC, Almeida GMdF.   +7 more
europepmc   +1 more source