Results 181 to 190 of about 5,348,273 (263)

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Comparative Analysis of Extracellular Vesicle-Like Particles From Different Processing <i>Gastrodia elata</i> Bl.: Physicochemical Properties, Biosafety, and Neuroprotection Potential as a Functional Food Ingredient. [PDF]

Food Sci Nutr
Qin Y, Li S, Yu J, Weng J, Li B, Liu X, Wang K, Yang Y, Jiao H, Wu J, Xu H.   +10 more
europepmc   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Lean Six Sigma for Sharps Waste Management and Occupational Biosafety in Emergency Care Units. [PDF]

Int J Environ Res Public Health
Ayres MAC, Korzenowski AL, Dos Anjos FEV, Toigo T, Notarjacomo MHB.   +4 more
europepmc   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Rapid Metagenomic Detection of <i>Brucella abortus</i> During a Two-Case Bovine Abortion Investigation in Inner Mongolia, China. [PDF]

Vet Sci
Xue T, Zhang B, Wang Z, Ma Y, Shen Q, Ding J, Yang X.   +6 more
europepmc   +1 more source

Black Hole Quencher‐Enhanced Plasmonic Photothermal Conversion

Advanced Science, EarlyView.
Researchers have developed a universal method to boost plasmonic photothermal conversion by attaching black hole quencher (BHQ) molecules to matched metal nanostructures. This hybrid approach increases efficiency by roughly threefold, reaching up to 69.1% in the near‐infrared‐II window.
Ruiyuan Zhang, Xinru Chen, Lin Shen, Jin Li   +3 more
wiley   +1 more source

Operationalizing the One Health approach in a conflict-affected setting: A scientometric review of policy foundations, systemic gaps, and future pathways in Ukraine. [PDF]

Vet World
Gerilovych A, Shevchenko N, Pishchanskyi O, Aliekseieva H, Rosada M, Gerilovych I, Okaievych O.   +6 more
europepmc   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Recombinant Attenuated <i>Salmonella</i> Enteritidis Vector Enhances the Immunogenicity of <i>Clostridium perfringens</i> EntB Antigen for Effective Prevention of Avian Necrotic Enteritis. [PDF]

Biomolecules
Li W, Li YA, Liu X, Xie H, Zhao J, Feng Y, Shi H.   +6 more
europepmc   +1 more source