Results 71 to 80 of about 420,917 (289)

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Measurements of Accuracy in Biostatistics [PDF]

, 2018
Due to the nature of biological and medical data, biostatistics has been playing an increasing role in a wide range of applications in biology and medicine.
Wang, Haiying / HY, Wassan, Jyotsna Talreja, Haiying Wang, Jyotsna Wassan, Zheng, Huiru, Huiru Zheng   +5 more
core   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Statistical challenges in the development and evaluation of marker-based clinical tests

BMC Medicine, 2012
Exciting new technologies for assessing markers in human specimens are now available to evaluate unprecedented types and numbers of variations in DNA, RNA, proteins, or biological structures such as chromosomes. These markers, whether viewed individually,
McShane Lisa M
doaj   +1 more source

Elevated liver enzymes is not an impediment to allopurinol dose escalation: an observational cohort study

Arthritis Care &Research, Accepted Article.
Objective Routine liver enzyme monitoring is advocated while on allopurinol but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzymes in gout patients commenced on allopurinol. Methods 150 patients with gout and normal baseline serum aminotransferases initiated on allopurinol were followed ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Bioestadística como apoyo a la praxis pedagógica de la Zoología de invertebrados en la determinación de Rotíferos de hábitat planctónico en el ecosistema de la laguna del Parque Recreacional de la ciudad de Cúcuta, aplicando las claves dicotómicas para su clasificación.

Ecomatemático, 2012
The study involved the identification and classification of phylum specimens rotifers from planktonic habitat in the recreational lagoon park ecosystem in Cucuta City.
María Eugenia Muñoz-Peñaloza , Yaneth Amparo Muñoz-Peñaloza , Mawency Vergel-Ortega   +2 more
doaj   +1 more source

A tutorial on the use of exploratory efficacy outcomes in uncontrolled phase I cell therapy trials

Stem Cells Translational Medicine, 2020
Phase I cell therapy clinical trials evaluate the safety of novel biologic treatments and are often uncontrolled. Many of these studies also include exploratory efficacy outcome measures, which are frequently continuous measures of disease state or ...
Jesse D. Troy
doaj   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Biostatistics @ Distance

, 2016
The Biostatistics Collaboration of Australia was formed to address the shortage of biostatisticians in that country. Academic biostatisticians are geographically spread out, with no single university department having the capacity to offer a graduate ...
Jobling, Erica, Heller, Gillian Z, Dear, Keith, Forbes, A.B., Dear, Keith B.G, Forbes, Andrew B   +5 more
core   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source