Results 61 to 70 of about 426,257 (254)

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

open access: yesArthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa   +3 more
wiley   +1 more source

Statistical challenges in the development and evaluation of marker-based clinical tests

open access: yesBMC Medicine, 2012
Exciting new technologies for assessing markers in human specimens are now available to evaluate unprecedented types and numbers of variations in DNA, RNA, proteins, or biological structures such as chromosomes. These markers, whether viewed individually,
McShane Lisa M
doaj   +1 more source

Composite likelihood for multiple multistate processes [PDF]

open access: yes, 2014
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Biostatistics following peer review. The version of record Biostat (2014) 15 (4): 690-705 first published online April 9, 2014 doi:10.1093/biostatistics/kxu011 is ...
Cook, Richard J., Diao, Liqun
core   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang   +4 more
wiley   +1 more source

Bioestadística como apoyo a la praxis pedagógica de la Zoología de invertebrados en la determinación de Rotíferos de hábitat planctónico en el ecosistema de la laguna del Parque Recreacional de la ciudad de Cúcuta, aplicando las claves dicotómicas para su clasificación.

open access: yesEcomatemático, 2012
The study involved the identification and classification of phylum specimens rotifers from planktonic habitat in the recreational lagoon park ecosystem in Cucuta City.
María Eugenia Muñoz-Peñaloza   +2 more
doaj   +1 more source

A tutorial on the use of exploratory efficacy outcomes in uncontrolled phase I cell therapy trials

open access: yesStem Cells Translational Medicine, 2020
Phase I cell therapy clinical trials evaluate the safety of novel biologic treatments and are often uncontrolled. Many of these studies also include exploratory efficacy outcome measures, which are frequently continuous measures of disease state or ...
Jesse D. Troy
doaj   +1 more source

Survival Outcomes in Older Adults With Axial Spondyloarthritis and Concomitant Cancer

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman   +7 more
wiley   +1 more source

Epidemiology, Biostatistics, and Research Design

open access: yes, 2017
This chapter reviews topics on epidemiology, biostatistics and research ...
Mark Oldham
core   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

open access: yesAdvanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao   +6 more
wiley   +1 more source

Sieve estimation in a Markov illness-death process under dual censoring [PDF]

open access: yes, 2016
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Bioinformatics following peer review. The version of record Boruvka, Audrey and Cook, Richard J. (2016). Biostatistics, 17(2): 350-363.
Boruvka, Audrey, Cook, Richard J.
core   +1 more source

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