Results 221 to 230 of about 1,587,544 (388)

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Piperine inhibits biofilm formation and efflux activity and dysregulates lipid metabolism in Mycobacterium abscessus. [PDF]

PLoS One
Htay TKK, Hathaway MR, Daniel J.
europepmc   +1 more source

Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells [PDF]

, 1977
G F Gibbons, Clive R. Pullinger
openalex   +1 more source

Biosynthesis and Antibacterial Activity of Silver Nanoparticles Using Medicinal Plants Associated Endophytic Bacteria From in Riyadh Region Saudi Arabia

, 2022
Monerah Saleh ALqahtani, Wael N. Hozzein, Sulaiman Ali Alharbi   +2 more
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Integrated transcriptome and metabolome analyses reveal key genes regulating jujuboside biosynthesis in <i>Ziziphus jujuba</i> var. <i>spinosa</i>. [PDF]

Front Plant Sci
Geng D, Yang X, Wang X, Chi X, Tang X, Ma X, Li X, Pu M, Shu J.   +8 more
europepmc   +1 more source

Biosynthesis of saturated and unsaturated fatty acids by a T-strain mycoplasma (Ureaplasma) [PDF]

, 1976
Nino Romano, Shlomo Rottem, Sergey V. Razin   +2 more
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Integrative Transcriptomics Reveals Regulatory Networks Underlying Fatty Acid and Lacquer Wax Formation in Fruit of <i>Toxicodendron vernicifluum</i>. [PDF]

Plants (Basel)
Li S, Xie Y, Zhang X, Wang X, Ge X, Zhou J, Chen C, Bai G.   +7 more
europepmc   +1 more source

Mechanism of the Biosynthesis of Vitamin A from β-Carotene

, 1966
DeWitt S. Goodman, Helen S. Huang, Tatsuji Shiratori   +2 more
openalex   +1 more source