Results 191 to 200 of about 99,198 (289)

Draft genome sequence of <i>Streptomyces</i> sp. strain G6 reveals biosynthetic gene clusters, including lanthipeptides with potential biomedical applications. [PDF]

Microbiol Resour Announc
Nada MAL, Bigol UG.
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Regulatory Genes as Beacons for Discovery and Prioritization of Biosynthetic Gene Clusters in <i>Streptomyces</i>. [PDF]

Biochemistry
Augustijn HE, van Nassauw D, Cernat S, Reitz ZL, van Wezel GP, Medema MH.   +5 more
europepmc   +1 more source

Butirosin Biosynthetic Gene Cluster from Bacillus circulans

Butirosin Biosynthetic Gene Cluster from Bacillus circulans
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source

PanBGC: a pangenome-inspired framework for comparative analysis of biosynthetic gene clusters. [PDF]

ISME Commun
Paccagnella D, Bağcı C, Gavriilidou A, Ziemert N.   +3 more
europepmc   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Multinuclear non-haem iron-dependent oxidative enzymes: landscape of their substrates, partner proteins and biosynthetic gene clusters. [PDF]

Microb Genom
Antoine R, Leprevost L, Jünger S, Zirah S, Lippens G, Li Y, Dubiley S, Jacob-Dubuisson F.   +7 more
europepmc   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science, EarlyView.
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
wiley   +1 more source

Genome mining reveals the distribution of biosynthetic gene clusters in Alternaria and related fungal taxa within the family Pleosporaceae. [PDF]

BMC Genomics
Kim NE, Dettman JR.
europepmc   +1 more source