Results 1 to 10 of about 172,296 (134)
AcaFinder: Genome Mining for Anti-CRISPR-Associated Genes
mSystems, 2022 Anti-CRISPR (Acr) proteins are encoded by (pro)viruses to inhibit their host’s CRISPR-Cas systems. Genes encoding Acr and Aca (Acr associated) proteins often colocalize to form acr-aca operons.
Bowen Yang, Jinfang Zheng, Yanbin Yin
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Computational and Structural Biotechnology Journal, 2020 Streptomyces are a large and valuable resource of bioactive and complex secondary metabolites, many of which have important clinical applications. With the advances in high throughput genome sequencing methods, various in silico genome mining strategies ...
Namil Lee +5 more
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Microbiology Spectrum, 2023 The prevalence of superbugs, represented by methicillin-resistant Staphylococcus aureus (MRSA), has become a serious clinical and public safety concern with rising incidence in hospitals.
Xi-Long Feng +11 more
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Effect of surface grain boundary density on preosteoblast proliferation on titanium
Materials Research Letters, 2020 Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold.
Terry C. Lowe +5 more
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Molecules, 2021 Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important ...
Khorshed Alam +10 more
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Genome Mining as New Challenge in Natural Products Discovery
Marine Drugs, 2020 Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as ...
Luisa Albarano +3 more
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Journal of Fungi, 2023 Fungi represents a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways.
Suhad A. A. Al-Salihi, Fabrizio Alberti
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Mining Pure, Strict Epistatic Interactions from High-Dimensional Datasets: Ameliorating the Curse of Dimensionality [PDF]
, 2012 Background: The interaction between loci to affect phenotype is called epistasis. It is strict epistasis if no proper subset of the interacting loci exhibits a marginal effect.
Richard E. Neapolitan +2 more
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Microorganisms, 2021 A promising keratin-degrading strain from the genus Chryseobacterium (Chryseobacterium sp. KMC2) was investigated using comparative genomic tools against three publicly available reference genomes to reveal the keratinolytic potential for biosynthesis of
Dingrong Kang +4 more
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Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides
Frontiers in Chemistry, 2022 Natural products derived from microorganisms play a prominent role in drug discovery as potential anti-infective agents. Over the past few decades, lipopeptides produced by particularly Bacillus, Pseudomonas, Streptomyces, Paenibacillus, and ...
Tanya Clements-Decker +3 more
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