Results 11 to 20 of about 80,951 (303)

Heavy Tools for Genome Mining [PDF]

open access: yesChemistry & Biology, 2007
In this issue of Chemistry & Biology, Gross et al. report development of a novel genome mining method for isolating products of orphan biosynthetic gene clusters, and the application of this method to the isolation of orfamide A, a novel cyclic lipopeptide.
Corre, Christophe, Challis, Gregory L.
openaire   +3 more sources

Genome mining of Streptomyces ambofaciens [PDF]

open access: yesJournal of Industrial Microbiology and Biotechnology, 2014
Abstract Since the discovery of the streptomycin produced by Streptomyces griseus in the middle of the last century, members of this bacterial genus have been largely exploited for the production of secondary metabolites with wide uses in medicine and in agriculture. They have even been recognized as one of the most prolific producers of
Aigle, Bertrand   +6 more
openaire   +6 more sources

The evolution of genome mining in microbes – a review [PDF]

open access: yesNatural Product Reports, 2016
This article reviews the development of genome mining strategies in bacteria during the last decade.
Nadine, Ziemert   +2 more
openaire   +5 more sources

Genome Mining and Synthetic Biology in Marine Natural Products Discovery [PDF]

open access: yes, 2021
In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community.

core   +1 more source

Genome-Mining-Guided Discovery and Characterization of the PKS-NRPS-Hybrid Polyoxyperuin Produced by a Marine-Derived Streptomycete [PDF]

open access: yes, 2022
The azinothricin family comprises several cyclic hexadepsipeptides with diverse pharmacological bioactivities, including antimicrobial, antitumoral, and apoptosis induction.
Virginia Linares Otoya (12192118)   +21 more
core   +1 more source

Genome Mining for Unknown-Unknown Natural Products [PDF]

open access: yes, 2022
Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to discovery of the so-called unknown (biosynthetic route)-unknown (molecular structure) natural products.
Kanji, Niwa   +5 more
core   +1 more source

Effect of surface grain boundary density on preosteoblast proliferation on titanium

open access: yesMaterials Research Letters, 2020
Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold.
Terry C. Lowe   +5 more
doaj   +1 more source

Genome Mining of Pseudomonas Species: Diversity and Evolution of Metabolic and Biosynthetic Potential

open access: yesMolecules, 2021
Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important ...
Khorshed Alam   +10 more
doaj   +1 more source

Genomic Based Analysis of the Biocontrol Species Trichoderma harzianum: A Model Resource of Structurally Diverse Pharmaceuticals and Biopesticides

open access: yesJournal of Fungi, 2023
Fungi represents a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways.
Suhad A. A. Al-Salihi, Fabrizio Alberti
doaj   +1 more source

Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production

open access: yesMicroorganisms, 2021
A promising keratin-degrading strain from the genus Chryseobacterium (Chryseobacterium sp. KMC2) was investigated using comparative genomic tools against three publicly available reference genomes to reveal the keratinolytic potential for biosynthesis of
Dingrong Kang   +4 more
doaj   +1 more source

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