Results 11 to 20 of about 1,533,401 (302)
Genome Mining as New Challenge in Natural Products Discovery
Marine Drugs, 2020 Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as ...
Luisa Albarano +3 more
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Computational and Structural Biotechnology Journal, 2020 Streptomyces are a large and valuable resource of bioactive and complex secondary metabolites, many of which have important clinical applications. With the advances in high throughput genome sequencing methods, various in silico genome mining strategies ...
Namil Lee +5 more
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Automated genome mining for natural products [PDF]
BMC Bioinformatics, 2009 Background Discovery of new medicinal agents from natural sources has largely been an adventitious process based on screening of plant and microbial extracts combined with bioassay-guided identification and natural product structure elucidation ...
Zajkowski James +4 more
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Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery
Marine Drugs, 2022 Large-scale genome-mining analyses have identified an enormous number of cryptic biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products.
Jessie James Limlingan Malit +2 more
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Discovery of bacterial terpenoids by genome mining. [PDF]
Methods EnzymolTerpenoid natural products are widely distributed in nature and possess diverse molecular structures that bestow remarkable biological activities. A tremendous number of terpenoids have been isolated from plants and fungi; however, traditional natural product discovery methods currently face challenges in the identification of new terpenoids due to the
Ning W, Rudolf JD.
europepmc +3 more sources
Genome Mining for New Enzyme Chemistry
ACS CatalysisA revolution in the field of biocatalysis has enabled scalable access to compounds of high societal values using enzymes. The construction of biocatalytic routes relies on the reservoir of available enzymatic transformations. A review of uncharacterized proteins predicted from genomic sequencing projects shows that a treasure trove of enzyme chemistry ...
Dinh Nguyen +2 more
exaly +3 more sources
Genome Mining and Synthetic Biology in Marine Natural Products Discovery [PDF]
, 2021 In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community.
core +1 more source
Clinics in Laboratory Medicine, 2008 This article reviews important emerging statistical concepts, data mining techniques, and applications that have been recently developed and used for genomic data analysis. First, general background and some critical issues in genomic data mining are summarized.
Jae K, Lee +2 more
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Genome mining for methanobactins [PDF]
BMC Biology, 2013 Methanobactins (Mbns) are a family of copper-binding natural products involved in copper uptake by methanotrophic bacteria. The few Mbns that have been structurally characterized feature copper coordination by two nitrogen-containing heterocycles next to thioamide groups embedded in a peptidic backbone of varying composition.
Kenney, Grace E, Rosenzweig, Amy C
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AcaFinder: Genome Mining for Anti-CRISPR-Associated Genes
mSystems, 2022 Anti-CRISPR (Acr) proteins are encoded by (pro)viruses to inhibit their host’s CRISPR-Cas systems. Genes encoding Acr and Aca (Acr associated) proteins often colocalize to form acr-aca operons.
Bowen Yang, Jinfang Zheng, Yanbin Yin
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