Results 11 to 20 of about 1,646,507 (307)
Genome Mining as New Challenge in Natural Products Discovery [PDF]
Marine Drugs, 2020 Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as ...
Nadia Ruocco +2 more
exaly +4 more sources
Computational and Structural Biotechnology Journal, 2020 Streptomyces are a large and valuable resource of bioactive and complex secondary metabolites, many of which have important clinical applications. With the advances in high throughput genome sequencing methods, various in silico genome mining strategies ...
Suhyung Cho +2 more
exaly +3 more sources
Chemistry & Biology, 2007 In this issue of Chemistry & Biology, Gross et al. report development of a novel genome mining method for isolating products of orphan biosynthetic gene clusters, and the application of this method to the isolation of orfamide A, a novel cyclic lipopeptide.
Corre, Christophe, Challis, Gregory L.
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Automated genome mining for natural products [PDF]
BMC Bioinformatics, 2009 Background Discovery of new medicinal agents from natural sources has largely been an adventitious process based on screening of plant and microbial extracts combined with bioassay-guided identification and natural product structure elucidation ...
Zajkowski James +4 more
doaj +5 more sources
Clinics in Laboratory Medicine, 2008 This article reviews important emerging statistical concepts, data mining techniques, and applications that have been recently developed and used for genomic data analysis. First, general background and some critical issues in genomic data mining are summarized.
Jae K, Lee +2 more
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Genome mining for methanobactins [PDF]
BMC Biology, 2013 Methanobactins (Mbns) are a family of copper-binding natural products involved in copper uptake by methanotrophic bacteria. The few Mbns that have been structurally characterized feature copper coordination by two nitrogen-containing heterocycles next to thioamide groups embedded in a peptidic backbone of varying composition.
Kenney, Grace E, Rosenzweig, Amy C
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AcaFinder: Genome Mining for Anti-CRISPR-Associated Genes
mSystems, 2022 Anti-CRISPR (Acr) proteins are encoded by (pro)viruses to inhibit their host’s CRISPR-Cas systems. Genes encoding Acr and Aca (Acr associated) proteins often colocalize to form acr-aca operons.
Bowen Yang, Jinfang Zheng, Yanbin Yin
doaj +1 more source
DGIdb: mining the druggable genome [PDF]
Nature Methods, 2013 The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http:/
Malachi Griffith +22 more
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Microbiology Spectrum, 2023 The prevalence of superbugs, represented by methicillin-resistant Staphylococcus aureus (MRSA), has become a serious clinical and public safety concern with rising incidence in hospitals.
Xi-Long Feng +11 more
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Effect of surface grain boundary density on preosteoblast proliferation on titanium
Materials Research Letters, 2020 Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold.
Terry C. Lowe +5 more
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