Results 41 to 50 of about 1,646,507 (307)

Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology

mSystems, 2018
Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development.
Marnix H. Medema
doaj   +1 more source

Marine-Derived Streptomyces sennicomposti GMY01 with Anti-Plasmodial and Anticancer Activities: Genome Analysis, In Vitro Bioassay, Metabolite Profiling, and Molecular Docking

Microorganisms, 2023
To discover novel antimalarial and anticancer compounds, we carried out a genome analysis, bioassay, metabolite profiling, and molecular docking of marine sediment actinobacteria strain GMY01. The whole-genome sequence analysis revealed that Streptomyces
Jaka Widada, Ema Damayanti, Mustofa Mustofa, Achmad Dinoto, Rifki Febriansah, Triana Hertiani   +5 more
doaj   +1 more source

Enhanced Bacterial Foraging Optimization Based on Progressive Exploitation Toward Local Optimum and Adaptive Raid

IEEE Access, 2019
Since the bacterial foraging optimization algorithm (BFO) was proposed, many variants about it have been designed in order to improve the performance and applied in different fields.
Dongxing Wang, Xu Qian, Xiaojuan Ban, Boyuan Ma, Yan Ma, Ziyi Lv   +5 more
doaj   +1 more source

Pseudomonassin, a New Bioactive Ribosomally Synthesised and Post-Translationally Modified Peptide from Pseudomonas sp. SST3

Microorganisms, 2023
Genome mining and metabolomics have become valuable tools in natural products research to evaluate and identify potential new chemistry from bacteria. In the search for new compounds from the deep-sea organism, Pseudomonas sp.
Kevin Jace Miranda, Saif Jaber, Dana Atoum, Subha Arjunan, Rainer Ebel, Marcel Jaspars, RuAngelie Edrada-Ebel   +6 more
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Genome data mining for everyone

BMB Reports, 2008
The genomic sequences of a huge number of species have been determined. Typically, these genome sequences and the associated annotation data are accessed through Internet-based genome browsers that offer a user-friendly interface. Intelligent use of the data should expedite biological knowledge discovery.
Gir Won, Lee, Sangsoo, Kim
openaire   +3 more sources

Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

Molecules, 2021
Streptomyces are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by ...
Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber   +13 more
doaj   +1 more source

Complete Genome Sequence of Two Deep-Sea Streptomyces Isolates from Madeira Archipelago and Evaluation of Their Biosynthetic Potential

Marine Drugs, 2021
The deep-sea constitutes a true unexplored frontier and a potential source of innovative drug scaffolds. Here, we present the genome sequence of two novel marine actinobacterial strains, MA3_2.13 and S07_1.15, isolated from deep-sea samples (sediments ...
Pedro Albuquerque, Inês Ribeiro, Sofia Correia, Ana Paula Mucha, Paula Tamagnini, Andreia Braga-Henriques, Maria de Fátima Carvalho, Marta V. Mendes   +7 more
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Peeling the Layers Away: The Genomic Characterization of Bacillus pumilus 64-1, an Isolate With Antimicrobial Activity From the Marine Sponge Plakina cyanorosea (Porifera, Homoscleromorpha)

Frontiers in Microbiology, 2021
Bacillus pumilus 64-1, a bacterial strain isolated from the marine sponge Plakina cyanorosea, which exhibits antimicrobial activity against both pathogenic and drug-resistant Gram-positive and Gram-negative bacteria.
Jéssyca Freitas-Silva, Bruno Francesco Rodrigues de Oliveira, Bruno Francesco Rodrigues de Oliveira, Felipe de Mello Vigoder, Guilherme Muricy, Alan D. W. Dobson, Alan D. W. Dobson, Marinella Silva Laport   +7 more
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Genome Mining Using Machine Learning Techniques

, 2015
A major milestone in modern biology was the complete sequencing of the human genome. But it produced a whole set of new challenges in exploring the functions and interactions of different parts of the genome. One application is predicting disorders based
Wlodarczak, Peter, Soar, Jeffrey, Ally, Mustafa, Jeffrey Soar, Peter Wlodarczak, Mustafa Ally   +5 more
core   +1 more source

Molecular Mapping of Reduced Plant Height Gene Rht24 in Bread Wheat

Frontiers in Plant Science, 2017
Height is an important trait related to plant architecture and yield potential in bread wheat (Triticum aestivum L.). We previously identified a major quantitative trait locus QPH.caas-6A flanked by simple sequence repeat markers Xbarc103 and Xwmc256 ...
Xiuling Tian, Xiuling Tian, Weie Wen, Weie Wen, Li Xie, Luping Fu, Dengan Xu, Chao Fu, Desen Wang, Xinmin Chen, Xianchun Xia, Xianchun Xia, Quanjia Chen, Zhonghu He, Zhonghu He, Shuanghe Cao   +15 more
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