Results 41 to 50 of about 1,533,401 (302)

Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology

mSystems, 2018
Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development.
Marnix H. Medema
doaj   +1 more source

Enhanced Bacterial Foraging Optimization Based on Progressive Exploitation Toward Local Optimum and Adaptive Raid

IEEE Access, 2019
Since the bacterial foraging optimization algorithm (BFO) was proposed, many variants about it have been designed in order to improve the performance and applied in different fields.
Dongxing Wang, Xu Qian, Xiaojuan Ban, Boyuan Ma, Yan Ma, Ziyi Lv   +5 more
doaj   +1 more source

Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

Molecules, 2021
Streptomyces are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by ...
Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber   +13 more
doaj   +1 more source

Complete Genome Sequence of Two Deep-Sea Streptomyces Isolates from Madeira Archipelago and Evaluation of Their Biosynthetic Potential

Marine Drugs, 2021
The deep-sea constitutes a true unexplored frontier and a potential source of innovative drug scaffolds. Here, we present the genome sequence of two novel marine actinobacterial strains, MA3_2.13 and S07_1.15, isolated from deep-sea samples (sediments ...
Pedro Albuquerque, Inês Ribeiro, Sofia Correia, Ana Paula Mucha, Paula Tamagnini, Andreia Braga-Henriques, Maria de Fátima Carvalho, Marta V. Mendes   +7 more
doaj   +1 more source

Peeling the Layers Away: The Genomic Characterization of Bacillus pumilus 64-1, an Isolate With Antimicrobial Activity From the Marine Sponge Plakina cyanorosea (Porifera, Homoscleromorpha)

Frontiers in Microbiology, 2021
Bacillus pumilus 64-1, a bacterial strain isolated from the marine sponge Plakina cyanorosea, which exhibits antimicrobial activity against both pathogenic and drug-resistant Gram-positive and Gram-negative bacteria.
Jéssyca Freitas-Silva, Bruno Francesco Rodrigues de Oliveira, Bruno Francesco Rodrigues de Oliveira, Felipe de Mello Vigoder, Guilherme Muricy, Alan D. W. Dobson, Alan D. W. Dobson, Marinella Silva Laport   +7 more
doaj   +1 more source

Genome-Mining-Guided Discovery and Characterization of the PKS-NRPS-Hybrid Polyoxyperuin Produced by a Marine-Derived Streptomycete

, 2022
The azinothricin family comprises several cyclic hexadepsipeptides with diverse pharmacological bioactivities, including antimicrobial, antitumoral, and apoptosis induction.
Virginia Linares Otoya (12192118), Zerlina G. Wuisan, I Dewa M. Kresna, Luis Linares Otoya, Zerlina G. Wuisan (6470330), Virginia Linares Otoya, Andreas Vilcinskas (68058), Andreas Vilcinskas, Jean-Marie Pohl (12192115), Michael Marner, Nils Böhringer, Ute Mettal (9380421), Nils Böhringer (12192124), Till F. Schäberle (1502716), Ute Mettal, Till F. Schäberle, Martin Gand (5703044), Martin Gand, I Dewa M. Kresna (12192112), Jean-Marie Pohl, Michael Marner (9268650), Luis Linares Otoya (12192121)   +21 more
core   +1 more source

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
core   +1 more source

Application of massive parallel sequencing to whole genome SNP discovery in the porcine genome [PDF]

, 2009
Background Although the Illumina 1 G Genome Analyzer generates billions of base pairs of sequence data, challenges arise in sequence selection due to the varying sequence quality.
Kerstens Hindrik HD, Heuven, H.C.M., Johan T den Dunnen, Henri CM Heuven, Andreia J Amaral, den Dunnen Johan T, Dibbits Bert, Groenen Martien AM, Heuven Henri CM, Megens, H.J.W.C., Amaral Andreia J, Megens Hendrik-Jan, Bert Dibbits, Martien AM Groenen, Groenen, M.A.M., Hendrik-Jan Megens, Dibbits, B.W., Dungen, J., den, Kerstens, H.H.D., Hindrik HD Kerstens, Richard PMA Crooijmans, Crooijmans, R.P.M.A., den Dungen, J., Crooijmans Richard PMA, Amaral, A.J.   +24 more
core   +1 more source

Genome Mining Using Machine Learning Techniques

, 2015
A major milestone in modern biology was the complete sequencing of the human genome. But it produced a whole set of new challenges in exploring the functions and interactions of different parts of the genome. One application is predicting disorders based
Wlodarczak, Peter, Soar, Jeffrey, Ally, Mustafa, Jeffrey Soar, Peter Wlodarczak, Mustafa Ally   +5 more
core   +1 more source

Genome Mining for Unknown-Unknown Natural Products [PDF]

, 2022
Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to discovery of the so-called unknown (biosynthetic route)-unknown (molecular structure) natural products.
Kanji, Niwa, Yuqing, Li, Danielle, Yee, Mengbin, Chen, Yi, Tang, Bruno, Perlatti   +5 more
core   +2 more sources