Results 21 to 30 of about 72,600 (260)

Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns

Synthetic and Systems Biotechnology, 2016
The increased number of annotated bacterial genomes provides a vast resource for genome mining. Several bacterial natural products with epoxide groups have been identified as pre-mRNA spliceosome inhibitors and antitumor compounds through genome mining ...
Xiangyang Liu
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Marine-Derived Streptomyces sennicomposti GMY01 with Anti-Plasmodial and Anticancer Activities: Genome Analysis, In Vitro Bioassay, Metabolite Profiling, and Molecular Docking

Microorganisms, 2023
To discover novel antimalarial and anticancer compounds, we carried out a genome analysis, bioassay, metabolite profiling, and molecular docking of marine sediment actinobacteria strain GMY01. The whole-genome sequence analysis revealed that Streptomyces
Jaka Widada, Ema Damayanti, Mustofa Mustofa, Achmad Dinoto, Rifki Febriansah, Triana Hertiani   +5 more
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Pseudomonassin, a New Bioactive Ribosomally Synthesised and Post-Translationally Modified Peptide from Pseudomonas sp. SST3

Microorganisms, 2023
Genome mining and metabolomics have become valuable tools in natural products research to evaluate and identify potential new chemistry from bacteria. In the search for new compounds from the deep-sea organism, Pseudomonas sp.
Kevin Jace Miranda, Saif Jaber, Dana Atoum, Subha Arjunan, Rainer Ebel, Marcel Jaspars, RuAngelie Edrada-Ebel   +6 more
doaj   +1 more source

Genome mining of Streptomyces ambofaciens [PDF]

Journal of Industrial Microbiology and Biotechnology, 2014
Abstract Since the discovery of the streptomycin produced by Streptomyces griseus in the middle of the last century, members of this bacterial genus have been largely exploited for the production of secondary metabolites with wide uses in medicine and in agriculture. They have even been recognized as one of the most prolific producers of
Aigle, Bertrand, Lautru, Sylvie, Spiteller, Dieter, Dickschat, Jeroen S., Challis, Gregory L., Leblond, Pierre, Pernodet, Jean-Luc   +6 more
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Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology

mSystems, 2018
Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development.
Marnix H. Medema
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Enhanced Bacterial Foraging Optimization Based on Progressive Exploitation Toward Local Optimum and Adaptive Raid

IEEE Access, 2019
Since the bacterial foraging optimization algorithm (BFO) was proposed, many variants about it have been designed in order to improve the performance and applied in different fields.
Dongxing Wang, Xu Qian, Xiaojuan Ban, Boyuan Ma, Yan Ma, Ziyi Lv   +5 more
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Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

Molecules, 2021
Streptomyces are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by ...
Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber   +13 more
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Heavy Tools for Genome Mining

Chemistry & Biology, 2007
In this issue of Chemistry & Biology, Gross et al. report development of a novel genome mining method for isolating products of orphan biosynthetic gene clusters, and the application of this method to the isolation of orfamide A, a novel cyclic lipopeptide.
Corre, Christophe, Challis, Gregory L.
openaire   +2 more sources

Complete Genome Sequence of Two Deep-Sea Streptomyces Isolates from Madeira Archipelago and Evaluation of Their Biosynthetic Potential

Marine Drugs, 2021
The deep-sea constitutes a true unexplored frontier and a potential source of innovative drug scaffolds. Here, we present the genome sequence of two novel marine actinobacterial strains, MA3_2.13 and S07_1.15, isolated from deep-sea samples (sediments ...
Pedro Albuquerque, Inês Ribeiro, Sofia Correia, Ana Paula Mucha, Paula Tamagnini, Andreia Braga-Henriques, Maria de Fátima Carvalho, Marta V. Mendes   +7 more
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Peeling the Layers Away: The Genomic Characterization of Bacillus pumilus 64-1, an Isolate With Antimicrobial Activity From the Marine Sponge Plakina cyanorosea (Porifera, Homoscleromorpha)

Frontiers in Microbiology, 2021
Bacillus pumilus 64-1, a bacterial strain isolated from the marine sponge Plakina cyanorosea, which exhibits antimicrobial activity against both pathogenic and drug-resistant Gram-positive and Gram-negative bacteria.
Jéssyca Freitas-Silva, Bruno Francesco Rodrigues de Oliveira, Bruno Francesco Rodrigues de Oliveira, Felipe de Mello Vigoder, Guilherme Muricy, Alan D. W. Dobson, Alan D. W. Dobson, Marinella Silva Laport   +7 more
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