Results 21 to 30 of about 1,533,401 (302)

DGIdb: mining the druggable genome [PDF]

Nature Methods, 2013
The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http:/
Malachi Griffith, Obi L Griffith, Adam C Coffman, James V Weible, Josh F McMichael, Nicholas C Spies, James Koval, Indraniel Das, Matthew B Callaway, James M Eldred, Christopher A Miller, Janakiraman Subramanian, Ramaswamy Govindan, Runjun D Kumar, Ron Bose, Li Ding, Jason R Walker, David E Larson, David J Dooling, Scott M Smith, Timothy J Ley, Elaine R Mardis, Richard K Wilson   +22 more
openaire   +2 more sources

Genomic and Metabolite Profiling Reveal a Novel Streptomyces Strain, QHH-9511, from the Qinghai-Tibet Plateau

Microbiology Spectrum, 2023
The prevalence of superbugs, represented by methicillin-resistant Staphylococcus aureus (MRSA), has become a serious clinical and public safety concern with rising incidence in hospitals.
Xi-Long Feng, Rui-Qi Zhang, Da-Cheng Wang, Wei-Ge Dong, Zhen-Xin Wang, Yi-Jie Zhai, Wen-Bo Han, Xia Yin, Junmian Tian, Jing Wei, Jin-Ming Gao, Jianzhao Qi   +11 more
doaj   +1 more source

Data Mining in Genomics and Proteomics [PDF]

BioMed Research International, 2005
There is no doubt that both computational biology and bioinformatics, and the interface of computer science and biology in general, are central to the future of biological research. The disciplines span a process that begins with data collection, analysis, classification, and integration, and ends with interpretation, modeling, visualization, and ...
Bensmail, Halima, Haoudi, Abdelali
openaire   +2 more sources

Effect of surface grain boundary density on preosteoblast proliferation on titanium

Materials Research Letters, 2020
Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold.
Terry C. Lowe, Rebecca A. Reiss, Patrick E. Illescas, Casey F. Davis, Melanie C. Connick, Johnny A. Sena   +5 more
doaj   +1 more source

Genome Mining of Pseudomonas Species: Diversity and Evolution of Metabolic and Biosynthetic Potential

Molecules, 2021
Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important ...
Khorshed Alam, Md. Mahmudul Islam, Caiyun Li, Sharmin Sultana, Lin Zhong, Qiyao Shen, Guangle Yu, Jinfang Hao, Youming Zhang, Ruijuan Li, Aiying Li   +10 more
doaj   +1 more source

Genomic Based Analysis of the Biocontrol Species Trichoderma harzianum: A Model Resource of Structurally Diverse Pharmaceuticals and Biopesticides

Journal of Fungi, 2023
Fungi represents a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways.
Suhad A. A. Al-Salihi, Fabrizio Alberti
doaj   +1 more source

Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production

Microorganisms, 2021
A promising keratin-degrading strain from the genus Chryseobacterium (Chryseobacterium sp. KMC2) was investigated using comparative genomic tools against three publicly available reference genomes to reveal the keratinolytic potential for biosynthesis of
Dingrong Kang, Saeed Shoaie, Samuel Jacquiod, Søren J. Sørensen, Rodrigo Ledesma-Amaro   +4 more
doaj   +1 more source

Pacificimonas pallium sp. nov., an Isolated Bacterium from the Mantle of Pacific Oyster Crassostrea gigas in Germany, and Prediction of One-Carbon Metabolism

Diversity, 2022
A yellow bacterium from marine agar, strain WHA3T, was isolated from the mantel of the Pacific oysters Crassostrea gigas in the Wilhelmshaven Sea in northern Germany.
Hani Pira, Chandra Risdian, Mathias Müsken, Peter J. Schupp, Joachim Wink   +4 more
doaj   +1 more source

Mining the draft human genome [PDF]

Nature, 2001
Now that the draft human genome sequence is available, everyone wants to be able to use it. However, we have perhaps become complacent about our ability to turn new genomes into lists of genes. The higher volume of data associated with a larger genome is accompanied by a much greater increase in complexity.
Birney, E, Bateman, A, Clamp, M E, Hubbard, T J   +3 more
openaire   +3 more sources

Ontology of core data mining entities [PDF]

, 2014
In this article, we present OntoDM-core, an ontology of core data mining entities. OntoDM-core defines themost essential datamining entities in a three-layered ontological structure comprising of a specification, an implementation and an application ...
Dzeroski, S, Soldatova, L, Panov, P
core   +1 more source