<i>Vogesella oryzagri</i> sp. nov., isolated from the rhizosphere of rice and <i>in silico</i> genome mining for the prediction of biosynthetic gene clusters. [PDF]
Huq MA +6 more
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Plasmid-Borne Biosynthetic Gene Clusters within a Permanently Stratified Marine Water Column. [PDF]
Mara P +5 more
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Genome sequences of six lactic acid bacteria from artisanal cheese reveal biosynthetic gene clusters encoding antimicrobial compounds. [PDF]
Gephart GJ, Abdelhamid AG, Yousef AE.
europepmc +1 more source
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ChemBioChem, 2022AbstractSalinipeptins belong to the type‐A linaridin class of ribosomally synthesized and post‐translationally modified peptides (RiPPs) comprising 22 amino acid residues with multiple D‐amino acids. Although chirality of other type‐A linaridins, such as grisemycin and cypemycin, has not been reported, the biosynthetic gene clusters of type‐A ...
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Lessons from the rifamycin biosynthetic gene cluster
Current Opinion in Chemical Biology, 1999There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of ...
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Nature Reviews Microbiology, 2015Gregory Challis
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2022Bacteria produce an impressive array of bioactive specialized metabolites, with Streptomyces (and the actinobacteria more generally) being unusually diverse and prolific producers. However, the biosynthetic potential of these organisms has yet to be fully explored, as many of the biosynthetic gene clusters that direct the synthesis of these natural ...
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Characterization of the Actinonin Biosynthetic Gene Cluster
ChemBioChem, 2018AbstractThe hydroxamate moiety of the natural product actinonin mediates inhibition of metalloproteinases because of its chelating properties towards divalent cations in the active site of those enzymes. Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates.
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