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Nat. Prod. Rep., 2011
Ergot alkaloids are toxins and important pharmaceuticals which are produced biotechnologically on an industrial scale. They have been identified in two orders of fungi and three families of higher plants. The most important producers are fungi of the genera Claviceps, Penicillium and Aspergillus (all belonging to the Ascomycota).
Christiane, Wallwey, Shu-Ming, Li
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Ergot alkaloids are toxins and important pharmaceuticals which are produced biotechnologically on an industrial scale. They have been identified in two orders of fungi and three families of higher plants. The most important producers are fungi of the genera Claviceps, Penicillium and Aspergillus (all belonging to the Ascomycota).
Christiane, Wallwey, Shu-Ming, Li
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Why biosynthetic genes for chemical defense compounds cluster
Trends in Plant Science, 2012In plants, the genomic clustering of non-homologous genes for the biosynthesis of chemical defense compounds is an emerging theme. Gene clustering is also observed for polymorphic sexual traits under balancing selection, and examples in plants are self-incompatibility and floral dimorphy.
Takos, Adam Matthew, Rook, Frederik
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Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
Mycological Research, 2008Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression
Ellen M, Fox, Barbara J, Howlett
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Biosynthetic Gene Clusters in Bacteria: A Review
Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 2022Soil is a nutrient-rich environment that harbors billions of microbial species. The diversity of microbes in an environment varies with the change in edaphic factors. To survive these environmental changes, microbes produce secondary metabolites which are not directly associated with their growth and reproduction. Bacterial genomes possess biosynthetic
Rimsha Dilshad, Nazia Jamil, Rida Batool
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A Bioinformatics Workflow for Investigating Fungal Biosynthetic Gene Clusters
2022Predicting secondary metabolite biosynthetic gene clusters is a routine analysis performed for each newly sequenced fungal genome. Yet, the usefulness of such predictions remains restricted as they provide total numbers of biosynthetic pathways with only very limited biological significance.
Collemare, J., Navarro-Munoz, J.C.
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A gene cluster of the ochratoxin A biosynthetic genes inPenicillium
Mycotoxin Research, 2006A putative ochratoxin A (OTA) biosynthetic gene cluster inP. nordicum has been identified. The first part of the gene cluster is located on a DNA fragment of 10 kb in length and harbours three genes. A gene with high homology to an alkaline serine protease gene (accession number AY557343), which represents the upstream border of the cluster ...
R, Geisen +2 more
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Expression of Cyanobacterial Biosynthetic Gene Clusters in Escherichia coli
2022Cyanobacteria represent an attractive source of natural bioactive compounds, ranging from sunscreens to cancer treatments. While many biosynthetic gene clusters (BGCs) that encode cyanobacterial natural products are known, the slow growth and lack of genetic tools in the native producers hampers their modification, characterization, and large-scale ...
Alescia, Cullen +2 more
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Defense-related phenylpropanoid biosynthetic gene clusters in rice
Science Bulletin, 2022Guy, Polturak, Anne, Osbourn
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MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Nucleic Acids ResearchSpecialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine.
Mitja M. Zdouc +287 more
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Genome Mining for Actinomycete Biosynthetic Gene Clusters
2018Whole-genome sequencing has shown that the large (8-12 Mbp) genomes of Streptomyces and allied genera of Gram-positive filamentous bacteria house a rich and previously underestimated repertoire of gene clusters for biosynthesis of specialised metabolites, including antibiotics, immunosuppressants and anticancer compounds.
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