C&EN Webinars - From mobility to Stability: Light Scattering Solutions for Formulating Stable Biotherapeutics [PDF]
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Abstract Objective Bacterial vaginosis, defined by Nugent score (Nugent‐BV), has been associated with preterm birth and other adverse pregnancy outcomes. However, few studies have longitudinally described the associations between Nugent‐BV and adverse pregnancy outcomes at varying times in pregnancy.
Daniel J. Erchick +15 more
wiley +1 more source
Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches. [PDF]
Burckhardt-Bravo V +2 more
europepmc +1 more source
ABSTRACT The gut microbiota is a dynamic community of bacteria, viruses, fungi, and archaea that plays a pivotal role in regulating host immunity, metabolism, and systemic homeostasis. Dysbiosis, characterized by an imbalance in the microbial composition, is being increasingly recognized as a contributor not only to gastrointestinal cancers but also to
Rishi Chowdhary +8 more
wiley +1 more source
Immunogenicity risk assessment for tailored mitigation and monitoring of biotherapeutics during development: recommendations from the European Immunogenicity Platform. [PDF]
Grudzinska-Goebel J +25 more
europepmc +1 more source
ABSTRACT Human papillomavirus (HPV) assays vary regarding the minimum amount of virus they detect. We investigated analytical thresholds of HPV detection and cervical screening sensitivity and specificity. One hundred cervical intraepithelial neoplasia grade 2 or worse (CIN2+) cases and 200 matched population‐based controls were obtained at the Swedish
Emel Yilmaz +22 more
wiley +1 more source
Genome-scale metabolic model-guided systematic framework for designing customized live biotherapeutic products. [PDF]
Lee YQ +11 more
europepmc +1 more source
Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang +8 more
wiley +1 more source
Microbiome Therapeutics for Clostridioides difficile Infection. [PDF]
Lucky CW +4 more
europepmc +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source

