Determining the Oxidation Mechanism through Radical Intermediates in Polysorbates 80 and 20 by Electron Paramagnetic Resonance Spectroscopy [PDF]
PharmaceuticalsPolysorbates 20 and 80 (PS20 and PS80) are added to many commercial biologic and vaccine pharmaceuticals. It is commonly known that these polysorbates undergo a radical oxidation mechanism; however, the identity of these radical intermediates has not ...
Adam T. Sutton, Richard R. Rustandi
exaly +5 more sources
Oxidation of polysorbates – An underestimated degradation pathway?
International Journal of Pharmaceutics: X, 2023 To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active compounds (surfactants) are added to protect biologics from denaturation and particle formation.
Karsten Maeder +2 more
exaly +8 more sources
Biological Surfactants vs. Polysorbates: Comparison of Their Emulsifier and Surfactant Properties [PDF]
Tenside, Surfactants, Detergents, 2018 In this work two biological surfactants, a cell-bound biosurfactant produced by Lactobacillus pentosus and a biosurfactant obtained from a fermented stream corn milling industry, were compared with two chemical surfactants (polysorbate 20 and polysorbate
Lorena Rodríguez-López +2 more
exaly +5 more sources
Polysorbates degrading enzymes in biotherapeutics – a current status and future perspectives [PDF]
Frontiers in Bioengineering and BiotechnologyPolysorbates, in particular polysorbate (PS) 20 and 80, are the most commonly used surfactants for stabilising biotherapeutics produced by biotechnological processes.
Marius Nicolaus Felix +5 more
doaj +3 more sources
Protein Formulations Containing Polysorbates: Are Metal Chelators Needed at All?
Antioxidants, 2020 Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy.
Ema Valentina Brovč +2 more
exaly +4 more sources
Substitution of polysorbates by plant-based emulsifiers: impact on vitamin D bioavailability and gut health in mice [PDF]
Communications BiologyAlthough long considered safe, recent data have shown that emulsifiers such as polysorbates promoted intestinal inflammation and were associated with increased risks of developing chronic pathologies. We evaluated the potential of plant-based emulsifiers
Ángela Bravo-Núñez +8 more
doaj +3 more sources
Molecules, 2022 Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and surface adsorption.
Hailong Zhang +7 more
doaj +2 more sources
Effect of Polysorbates on the Growth of Rhodotorula Glutinis in Oil Rich Medium
Environmental and Climate Technologies, 2021 The present study has investigated the effect of oil rich medium supplementation with polysorbates Tween 20, 40 and 80, for the cultivation of red oleaginous yeast Rhodotorula glutinis. R.
Raita Svetlana +4 more
doaj +2 more sources
Effects of Selected Polysorbate and Sucrose Ester Emulsifiers on the Physicochemical Properties of Astaxanthin Nanodispersions [PDF]
Molecules, 2013 The effects of selected nonionic emulsifiers on the physicochemical characteristics of astaxanthin nanodispersions produced by an emulsification/evaporation technique were studied.
Navideh Anarjan, Chin Ping Tan
doaj +5 more sources
Pharmaceutical Analysis of Protein-Peptide Coformulations and the Influence of Polysorbates. [PDF]
Mol PharmCoformulation is an approach to formulating multiple biopharmaceutical therapeutics in a single formulation, promising the benefits of both therapies in one dose.
Whiteley J +5 more
europepmc +2 more sources