Determining the Oxidation Mechanism through Radical Intermediates in Polysorbates 80 and 20 by Electron Paramagnetic Resonance Spectroscopy [PDF]
PharmaceuticalsPolysorbates 20 and 80 (PS20 and PS80) are added to many commercial biologic and vaccine pharmaceuticals. It is commonly known that these polysorbates undergo a radical oxidation mechanism; however, the identity of these radical intermediates has not ...
Richard Rustandi
exaly +4 more sources
Effects of Different Polysorbates (Tween) on Recombined Whipped Cream: Interfacial Properties, Stability, and Aeration Properties [PDF]
FoodsEmulsifiers play a crucial role in improving the shelf-life stability and aeration quality of recombined whipped cream (RDC). This study systematically investigated the interfacial adsorption behaviors of four types of polysorbates (Tween20, Tween40 ...
Yingjun Zuo +3 more
doaj +2 more sources
A Narrative Literature Review of the Established Safety of Human Serum Albumin Use as a Stabilizer in Aesthetic Botulinum Toxin Formulations Compared to Alternatives [PDF]
Toxins, 2023 Despite more than 80 years of use in a number of conditions, including in critically ill patients, comments have recently arisen regarding the safety and efficacy of human serum albumin (HSA) as a therapeutic product and stabilizer/excipient in botulinum
Sonja Sattler +2 more
doaj +2 more sources
Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation [PDF]
PharmaceuticalsMonoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities.
Jiayi Huang +7 more
doaj +2 more sources
Protein Formulations Containing Polysorbates: Are Metal Chelators Needed at All?
Antioxidants, 2020 Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy.
Ema Valentina Brovč +2 more
exaly +3 more sources
Oxidation of polysorbates – An underestimated degradation pathway?
International Journal of Pharmaceutics: X, 2023 To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active compounds (surfactants) are added to protect biologics from denaturation and particle formation.
Patrick Garidel, Julia Buske
exaly +3 more sources
Phosphatidylcholine-Polysorbate 20-Based Mixed Micelles: A New Option to Prevent Protein Aggregation? [PDF]
PharmaceuticsBackground/Objectives: Surfactants are commonly used to protect proteins from denaturation and particle formation, thereby ensuring the long-term stability of biopharmaceuticals.
Johanna Weber +4 more
doaj +2 more sources
Polysorbates degrading enzymes in biotherapeutics – a current status and future perspectives [PDF]
Frontiers in Bioengineering and BiotechnologyPolysorbates, in particular polysorbate (PS) 20 and 80, are the most commonly used surfactants for stabilising biotherapeutics produced by biotechnological processes.
Marius Nicolaus Felix +5 more
doaj +2 more sources
Polysorbates’ effects on molecular and thermodynamic properties of phosphorodiamidate morpholino oligonucleotides’ structures [PDF]
Molecular Therapy: Nucleic AcidsElucidating the structure-function relationships of phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to limited structural data.
Evgenii Kliuchnikov +6 more
doaj +2 more sources
Molecules, 2022 Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and surface adsorption.
Hailong Zhang +7 more
doaj +1 more source