Results 1 to 10 of about 1,377,424 (162)

Computational models for studying physical instabilities in high concentration biotherapeutic formulations [PDF]

MAbs, 2022
Computational prediction of the behavior of concentrated protein solutions is particularly advantageous in early development stages of biotherapeutics when material availability is limited and a large set of formulation conditions needs to be explored ...
Marco Blanco
exaly   +7 more sources

Unexplored Excipients in Biotherapeutic Formulations: Natural Osmolytes as Potential Stabilizers Against Thermally Induced Aggregation of IgG1 Biotherapeutics. [PDF]

AAPS PharmSciTech, 2021
Monoclonal antibodies (mAbs), while incredibly successful, are prone to a variety of degradation pathways, the most significant of which is aggregation.
Bhojane PP, Joshi S, Sahoo SJ, Rathore AS.   +3 more
europepmc   +5 more sources

Transfer Learning Analysis for Subvisible Particle Flow Imaging of Pharmaceutical Formulations

Applied Sciences, 2022
Subvisible particles are an ongoing problem in biotherapeutic injectable pharmaceutical formulations, and their identification is an important prerequisite for tracing them back to their source and optimizing the process. Flow imaging microscopy (FIM) is
Xiangan Long, Chongjun Ma, Han Sheng, Liwen Chen, Yiyan Fei, Lan Mi, Dongmei Han, Jiong Ma   +7 more
doaj   +2 more sources

Simultaneous Spray Drying for Combination Dry Powder Inhaler Formulations

Pharmaceutics, 2022
Spray drying is a particle engineering technique used to manufacture respirable pharmaceutical powders that are suitable for delivery to the deep lung. It is amenable to processing both small molecules and biologic actives, including proteins.
Kimberly B. Shepard, Amanda M. Pluntze, David T. Vodak   +2 more
doaj   +2 more sources

Rapid Profiling, Fingerprinting, and Speciation of Poloxamer 188 in Biotherapeutic Drug Production Using Comprehensive Liquid Chromatography-Charge Reduction Mass Spectrometry Analysis. [PDF]

ACS Omega
Poloxamer 188 (P188) is an alternative surfactant to polysorbates in biologic formulations, stabilizing biotherapeutic drugs in solution. By mitigating the inherent risk of polysorbate 20/80 (PS 20/80) degradation by host cell proteins, P188 ensured ...
Yang RS, Wang H, Welch J, Carrillo R, Blanco M, Richardson D, Schuessler H.   +6 more
europepmc   +2 more sources

Turning diverse analytical data into actionable knowledge for enzymatically driven polysorbate degradation risk assessment and control in biotherapeutic protein formulations

Journal of Pharmaceutical and Biomedical Analysis Open
Anita Liu, Fengqiang Wang, Alex Dow
exaly   +3 more sources

Saccharomyces cerevisiae reduces vulvovaginal candidiasis severity through modulation of fungal pathogenicity and inflammatory responses [PDF]

Nature Communications
Vulvovaginal candidiasis (VVC) affects millions of women globally and is characterized by multifactorial immunopathology, with Candida albicans virulence driving disease progression through epithelial tissue damage and neutrophil hyperactivation and ...
Mart Sillen, Dania El Abyad, Nina Vreys, Silke Baldewijns, Ilse Palmans, Odessa Van Goethem, Kar On Cheng, Greetje Vande Velde, Dolly E. Montaño, Nele Berghmans, Mieke Gouwy, Agustin R. Sharpe, Lies De Groef, Axel Dietschmann, Paul Vandecruys, Sarah Lebeer, Liesbeth Demuyser, Mark S. Gresnigt, Patrick Van Dijck   +18 more
doaj   +2 more sources

Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

Frontiers in Microbiology, 2017
Spore-forming bacilli are being explored for the production and preservation of food for many centuries. The inherent ability of production of large number of secretory proteins, enzymes, antimicrobial compounds, vitamins, and carotenoids specifies the ...
Fouad M. F. Elshaghabee, Namita Rokana, Rohini D. Gulhane, Chetan Sharma, Harsh Panwar   +4 more
doaj   +2 more sources

A Comprehensive Evaluation of Analytical Method Parameters Critical to the Reliable Assessment of Therapeutic mRNA Integrity by Capillary Gel Electrophoresis. [PDF]

Electrophoresis
In recent years, messenger ribonucleic acid (mRNA)‐lipid nanoparticle (LNP) biotherapeutics have demonstrated significant promise in disease treatment and prevention given their rapidly modifiable production processes and considerable capacity to adapt ...
Tran JP, Gao J, Lansdell C, Lorbetskie B, Johnston MJW, Wang L, Li X, Lu H.   +7 more
europepmc   +2 more sources

Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation

Pharmaceutics, 2023
The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality.
Benedykt Kozuch, Johanna Weber, Julia Buske, Karsten Mäder, Patrick Garidel, Tim Diederichs   +5 more
doaj   +1 more source