Results 1 to 10 of about 2,536 (255)
Computational models for studying physical instabilities in high concentration biotherapeutic formulations [PDF]
MAbs, 2022 Computational prediction of the behavior of concentrated protein solutions is particularly advantageous in early development stages of biotherapeutics when material availability is limited and a large set of formulation conditions needs to be explored ...
Marco A Blanco
exaly +6 more sources
Oxidation of polysorbates – An underestimated degradation pathway? [PDF]
International Journal of Pharmaceutics: X, 2023 To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active compounds (surfactants) are added to protect biologics from denaturation and particle formation.
Johanna Weber +4 more
doaj +3 more sources
Phosphatidylcholine-Polysorbate 20-Based Mixed Micelles: A New Option to Prevent Protein Aggregation? [PDF]
PharmaceuticsBackground/Objectives: Surfactants are commonly used to protect proteins from denaturation and particle formation, thereby ensuring the long-term stability of biopharmaceuticals.
Johanna Weber +4 more
doaj +2 more sources
Pharmaceutics, 2022 Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years.
Angel J. Castañeda Ruiz +6 more
doaj +1 more source
Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation
Pharmaceutics, 2023 The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality.
Benedykt Kozuch +5 more
doaj +1 more source
Transfer Learning Analysis for Subvisible Particle Flow Imaging of Pharmaceutical Formulations
Applied Sciences, 2022 Subvisible particles are an ongoing problem in biotherapeutic injectable pharmaceutical formulations, and their identification is an important prerequisite for tracing them back to their source and optimizing the process. Flow imaging microscopy (FIM) is
Xiangan Long +7 more
doaj +1 more source
Simultaneous Spray Drying for Combination Dry Powder Inhaler Formulations
Pharmaceutics, 2022 Spray drying is a particle engineering technique used to manufacture respirable pharmaceutical powders that are suitable for delivery to the deep lung. It is amenable to processing both small molecules and biologic actives, including proteins.
Kimberly B. Shepard +2 more
doaj +1 more source
Pharmaceutics, 2022 Faecalibacterium duncaniae is an intestinal commensal bacterium proposed as a next-generation probiotic due to its promising outcomes in the treatment and prevention of several human diseases, which demonstrate its multiple contributions to the host’s ...
Daniela Machado +6 more
doaj +1 more source
Postbiotics and their biotherapeutic potential for chronic disease and their feature perspective: a review [PDF]
Frontiers in MicrobiomesAsefa Z, Belay A, Welelaw E, Haile M.
exaly +2 more sources
mAbs, 2023 There is considerable interest in the pharmaceutical industry toward development of antibody-based biotherapeutics because they can selectively bind diverse receptors and often possess desirable pharmacology.
Kyle P. Martin +4 more
doaj +1 more source