Results 41 to 50 of about 1,377,424 (162)

Challenges and developments in the manufacturing of high-concentration biotherapeutic monoclonal antibodies.

Advanced Drug Delivery Reviews
The past two decades have witnessed the rise of biotherapeutics as safe and effective solutions for curing or managing a spectrum of hard-to-treat diseases. Monoclonal antibodies (mAbs) form one of the most successful subclasses of biotherapeutics due to
Anurag S. Rathore, Subhankar Metya, Rashmi Sharma, Nitika Nitika   +3 more
semanticscholar   +1 more source

Mechanistic and predictive formulation development for viscosity mitigation of high-concentration biotherapeutics

mAbs
Proteins are an important class of therapeutics for combatting a wide variety of diseases. The increasing demand for convenient, patient-centric treatment options has propelled the development of subcutaneously delivered protein therapies and increased the interest in novel formulations and delivery methods.
Matthew A Cruz, Marco Blanco, Iriny Ekladious   +2 more
openaire   +2 more sources

Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern [PDF]

Journal of Excipients and Food Chemicals
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
doaj  

Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern

Journal of Excipients and Food Chemicals, 2016
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
doaj  

Development and Evaluation of Live Biotherapeutic Product in the form of Mucoadhesive Vaginal Tablets containing living Lactobacillus spp.

Ars Pharmaceutica
Introduction: This study aimed to develop and evaluate mucoadhesive vaginal tablets containing viable Lactobacillus spp., with a focus on the impact of formulation composition and processing parameters on product properties and performance.
Aleksandar Aleksovski, Haniehsadat Hosseini, Hajar Alkhafaji   +2 more
semanticscholar   +1 more source

Distinct Limosilactobacillus reuteri microcapsule models: construction and therapeutic evaluation in DSS-induced colitis mice

npj Science of Food
The limited stability of L. reuteri in liquid formulations during storage, transport, and gastrointestinal transit presents a major challenge for its application as a probiotic.
Song Xu, Ruiqin Han, Zhipeng Zhang, Jingjing Wang, Xiaoxia Zhang, Zhiyong Huang   +5 more
doaj   +1 more source

Hyperspectral Imaging Techniques for Lyophilization: Advances in Data‐Driven Modeling Strategies and Applications

Advanced Science
Lyophilization, aka freeze drying, is a key process used in the production of biotherapeutic products. The optimization of lyophilization formulations and operations is a slow process that could be accelerated by on‐line analytics.
Huiwen Yu, Prakitr Srisuma, Cedric Devos, Jie Wang, Allan S. Myerson, Richard D. Braatz   +5 more
doaj   +1 more source

Experimental Design in Pharmaceutical Formulation Development: Achievements, Limitations and the Transition Toward Intelligent Optimization

Scientia Pharmaceutica
Historically, pharmaceutical formulation development relied heavily on trial-and-error experimentation, which was useful for empirical progress but often provided limited mechanistic understanding and insufficient efficiency for increasingly complex drug
Ayşe Türkdoğan, Tarek Alloush, Burcu Demiralp   +2 more
doaj   +1 more source

Skin microbiome and cutaneous aging mechanisms and clinical implications

Frontiers in Microbiology
The skin microbiome is an integral component of the cutaneous ecosystem and contributes to barrier, immune, and metabolic homeostasis. Available evidence is examined across three distinct levels: microbial community structure, functional activity, and ...
Jhommara Bautista, Andrea Iñiguez-Ramírez, Jaime Andrés Villegas-Chávez, Doménica Bunces-Larco, Andrés López-Cortés   +4 more
doaj   +1 more source

Efficacy of bacteriophages with Aloe vera extract in formulated cosmetics to combat multidrug-resistant bacteria in skin diseases

Scientific Reports
Phage therapy offers a promising alternative to antibiotic treatment for combating illnesses caused by multidrug-resistant bacteria. In this study, pathogenic bacteria Staphylococcus aureus and Pseudomonas aeruginosa were isolated from pus and skin ...
Sodaf A. Maan, Abeer A. Faiesal, Gamar M. Gamar, Noha K. El Dougdoug   +3 more
doaj   +1 more source