Results 21 to 30 of about 1,377,424 (162)

Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics

mAbs, 2023
There is considerable interest in the pharmaceutical industry toward development of antibody-based biotherapeutics because they can selectively bind diverse receptors and often possess desirable pharmacology.
Kyle P. Martin, Christine Grimaldi, Rolf Grempler, Steven Hansel, Sandeep Kumar   +4 more
doaj   +1 more source

Applications and analysis of hydrolysates in animal cell culture

Bioresources and Bioprocessing, 2021
Animal cells are used in the manufacturing of complex biotherapeutic products since the 1980s. From its initial uses in biological research to its current importance in the biopharmaceutical industry, many types of culture media were developed: from ...
Yin Ying Ho, Hao Kim Lu, Zhi Feng Sherman Lim, Hao Wei Lim, Ying Swan Ho, Say Kong Ng   +5 more
doaj   +1 more source

Postbiotics and their biotherapeutic potential for chronic disease and their feature perspective: a review [PDF]

Frontiers in Microbiomes
Asefa Z, Belay A, Welelaw E, Haile M.
exaly   +2 more sources

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Antioxidants, 2023
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles.
James Melrose
doaj   +1 more source

Formulation and characterization of vaginal capsules and tablets providing fast release of live Lactobacillus spp. [PDF]

Arhiv za farmaciju
Live biotherapeutic products (LBPs) are gaining significant medical importance as a new approach in the prevention and treatment of various conditions in the female population.
Aleksovski Aleksandar, Hosseini Haniehsadat, Alkhafaji Hajar, Leite Michaëla, Sagasta Ander, Leopold Viviane   +5 more
doaj   +1 more source

Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections

Microbial Biotechnology, 2023
Respiratory viruses such as influenza viruses, respiratory syncytial virus (RSV), and coronaviruses initiate infection at the mucosal surfaces of the upper respiratory tract (URT), where the resident respiratory microbiome has an important gatekeeper ...
Irina Spacova, Ilke De Boeck, Eline Cauwenberghs, Lize Delanghe, Peter A. Bron, Tim Henkens, Alix Simons, Imane Gamgami, Leentje Persoons, Ingmar Claes, Marianne F. L. van denBroek, Dominique Schols, Peter Delputte, Samuel Coenen, Veronique Verhoeven, Sarah Lebeer   +15 more
doaj   +1 more source

Adipose derived mesenchymal stem cell secretome formulation as a biotherapeutic to inhibit growth of drug resistant triple negative breast cancer [PDF]

Scientific Reports, 2021
AbstractIn the present study, a protocol was developed for processing of human adipose derived mesenchymal stem cell secretome formulation of varying concentration. Its molecular composition was evaluated, and its effectiveness in vitro using breast cancer cell lines, and in vivo in a nude mice breast cancer model was studied to determine its role in ...
Ragima Nadesh, Krishnakumar N. Menon, Lalitha Biswas, Ullas Mony, K. Subramania Iyer, Sundeep Vijayaraghavan, Ajit Nambiar, Shantikumar Nair   +7 more
openaire   +3 more sources

The role of the gut microbiome in colonization resistance and recurrent infection

Therapeutic Advances in Gastroenterology, 2022
The species composition of the human gut microbiota is related to overall health, and a healthy gut microbiome is crucial in maintaining colonization resistance against pathogens.
Anna Maria Seekatz, Nasia Safdar, Sahil Khanna   +2 more
doaj   +1 more source

Toward Biotherapeutics Formulation Composition Engineering using Site-Identification by Ligand Competitive Saturation (SILCS)

Journal of Pharmaceutical Sciences, 2021
Formulation of protein-based therapeutics employ advanced formulation and analytical technologies for screening various parameters such as buffer, pH, and excipients. At a molecular level, physico-chemical properties of a protein formulation depend on self-interaction between protein molecules, protein-solvent and protein-excipient interactions.
Sandeep, Somani, Sunhwan, Jo, Renuka, Thirumangalathu, Danika, Rodrigues, Laura M, Tanenbaum, Ketan, Amin, Alexander D, MacKerell, Santosh V, Thakkar   +7 more
openaire   +3 more sources

RBX7455, a Non-frozen, Orally Administered Investigational Live Biotherapeutic, Is Safe, Effective, and Shifts Patients’ Microbiomes in a Phase 1 Study for Recurrent Clostridioides difficile Infections

Clinical Infectious Diseases, 2020
Background Recurrent Clostridioides difficile infections (rCDI) are a global public health threat. To reduce rCDI, microbiota-restoring therapies are needed, particularly standardized, easy-to-administer formulations.
S. Khanna, D. Pardi, Courtney Jones, W. Shannon, Carlos A. González, Ken F Blount   +5 more
semanticscholar   +1 more source