Results 31 to 40 of about 2,536 (255)

Live Biotherapeutic Products and Probiotics for the Skin [PDF]

, 2021
The skin microbiome is essential for the proper barrier functions of the skin, preventing the invasion of pathogens and regulating immune responses. When disrupted, recurrent conditions including atopic dermatitis, acne, or chronic wounds can result ...
Anselmo, Aaron C., Vargason, Ava M.
core   +2 more sources

Depletion of Saccharomyces cerevisiae in psoriasis patients, restored by Dimethylfumarate therapy (DMF) [PDF]

, 2017
Background Psoriasis and inflammatory bowel disease (IBD) are chronic inflammatory diseases sharing similar pathogenic pathways. Intestinal microbial changes such as a decrease of bakers' yeast Saccharomyces cerevisiae have been reported in IBD ...
Blakaj, B. (Blerdi), Eppinga, H. (Hester), Fuhler, G.M. (Gwenny), Konstantinov, S.R. (Sergey), Peppelenbosch, M.P. (Maikel), Schreurs, M.W.J. (Marco), Tahitu, R.I. (Ruena I.), Thio, H.B. (Bing)   +7 more
core   +5 more sources

Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX [PDF]

, 2017
The putative protective role of the exopolysaccharide (EPS)-producing Lactobacillus paraplantarum BGCG11, and its non-EPS-producing isogenic strain NB1, was tested upon HT29-MTX monolayers challenged with seven opportunistic pathogens.
Golic, Natasa, Gueimonde Fernández, Miguel, Hidalgo-Cantabrana, Claudio, Kojic, Milan, Ruas-Madiedo, Patricia, Zivkovic, Milica   +5 more
core   +1 more source

RNA aptamer delivery through intact human skin [PDF]

, 2018
It is generally recognised that only relatively small molecular weight (typically 100,000-fold) and aptamer integrity was confirmed using an oligonucleotide precipitation assay.
Brown, M. B., Cote-Sierra, J., Demock, K., Donahue, C., Killough, J., Lenn, J. D., Neil, J., Pendergrast, P. S., Rubenstein, D., Smith, S. H., Therrien, J.-P., Tibbetts, C. V., Williams, Adrian   +12 more
core   +3 more sources

Live biotherapeutic products and their regulatory framework in Italy and Europe [PDF]

, 2023
In Italy and Europe, live microorganisms-containing products meant to be used by vulnerable or sick people for preventing or curing a disease are defined as live biotherapeutic products and are regulated as biological drugs.
Franciosa, Giovanna, Gomez Miguel, Maria Jesus, Guida, Serena, Von Hunolstein, Christina   +3 more
core   +2 more sources

Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota [PDF]

, 2019
Human campylobacteriosis constitutes a zoonotic food-borne disease and a progressively rising health burden of significant socioeconomic impact. We have recently shown that conventional mice are protected from Campylobacter jejuni infection, which was ...
Bereswill, Stefan, Heimesaat, Markus M., Mrazek, Katharina   +2 more
core   +1 more source

Biotherapeutic Formulation Factors Affecting Metal Leachables from Stainless Steel Studied by Design of Experiments [PDF]

AAPS PharmSciTech, 2012
Trace amounts of metals are inevitably present in biotherapeutic products. They can arise from various sources. The impact of common formulation factors such as protein concentration, antioxidant, metal chelator concentration and type, surfactant, pH, and contact time with stainless steel on metal leachables was investigated by a design of experiments ...
Shuxia, Zhou, Brad, Evans, Christian, Schöneich, Satish K, Singh   +3 more
openaire   +2 more sources

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo [PDF]

, 2016
Uncontrolled self-association is a major challenge in the exploitation of proteins as therapeutics. Here we describe the development of a structural proteomics approach to identify the amino acids responsible for aberrant self-association of monoclonal ...
A Lahlou, A Saluja, A Schoch, AJ McCoy, AS Rosenberg, B Li, C Faber, CJ Roberts, D Bumbaca, D Seeliger, DK Finch, DR Holland, EA Kabat, EY Chi, GN Murshudov, H Wu, I Hotzel, J Arora, J Loo, J Snijder, J Zhang, JJ Phillips, JM Reichert, JS Philo, K Breuker, KD Ratanji, L Liu, L Persic, LA Woods, M Groves, MD Winn, ME Cromwell, MJ Edgeworth, N Chennamsetty, N Kohli, O Daramola, O Feyen, O Obrezanova, OS Smart, P Emsley, P Schuck, R Deng, RB Pepinsky, RH Clark, RL Kelly, SA Jacobs, SJ Wu, T Igawa, TE Wales, TG Battye, VK Sharma, W Wang, Y Vugmeyster, Y Xu   +53 more
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Hijacking bacterial glycosylation for the production of glycoconjugates, from vaccines to humanised glycoproteins. [PDF]

, 2014
OBJECTIVES: Glycosylation or the modification of a cellular component with a carbohydrate moiety has been demonstrated in all three domains of life as a basic post-translational process important in a range of biological processes. This review will focus
Aggarwal, Avci, Avery, Bentley, Benz, Bertozzi, Brady, Brendan Wren, Byrd, Byrd, Chen, Chu, Coutinho, Cuccui, Daugla, Descroix, Faridmoayer, Faridmoayer, Feldman, Fisher, Flesher, Fry, Ghaderi, Grass, Grijalva, Guerry, Hug, Ielmini, Ihssen, Iwashkiw, Iwashkiw, Jenkins, Jon Cuccui, Karlyshev, Kowarik, Kowarik, Kuberan, Ladhani, Linton, Lithgow, Lizak, Lomino, McCann, Meuris, Naegeli, Nystedt, Parkhill, Petrescu, Schneerson, Schneerson, Schwarz, Scott, Shi, Sleytr, Son, Szymanski, Timens, Valderrama-Rincon, Varki, Varki, Wacker, Wacker, Watt, Yazdankhah, Young, Zielinska   +65 more
core   +1 more source

Triple negative breast cancer: nanosolutions for a big challenge [PDF]

, 2015
Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene ...
Adams, Aebi, Ahn, Ali, Almuhaideb, Arpino, Awada, Ayala-Orozco, Bar, Baselga, Baselga, Baselga, Bauer, Bawarski, Bertos, Bianco, Boyle, Brigger, Brown, Burke, Burstein, Cardoso, Carey, Chen, Chen, Cho, Crisp, Crown, Dai, Davis, DeNardo, Dent, Dogan, Duncan, Engebraaten, Fauzee, Feng, Ferrari, Ferraro, Finlay, Franchina, Ghosh, Goldhirsch, Gonzalez-Angulo, Gref, Grobmyer, Gu, Hammond, Herranz, Hirsch, Hong, Huang, Hun, Hussein, Iida, Inoue, Jain, Jain, Jin, Johnstone, Joshi, Julien, Kadioglu, Kang, Kaur, Kircher, Ko, Krag, Kucuk, Kutty, Kutty, Lainé, Lamprecht, Lay, LeBeau, Lee, Lehmann, Li, Liu, Ljubimova, Ljubimova, Lund, Lyshchik, Ma, Ma, Maeda, Matsumura, Matsumura, Meier, Meng, Mikhail, Mittapalli, Montagna, Mura, O'Toole, Oakman, Ossovskaya, Owens, Palma, Park, Passarella, Passarella, Penault-Llorca, Raha, Raoof, Reubi, Rodrigues, Rodrigues, Rousseau, Sahoo, Schmadeka, Sharma, Sharma, Shi, Shi, Siegel, Svenson, Tacar, Tan, Taurin, Tekedereli, Thomas, Tinoco, Tobio, Torchilin, Tran, Turner, van Scheltinga, van Scheltinga, Wang, Wang, Yu, Yu, Zhu   +133 more
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