Results 31 to 40 of about 1,377,424 (162)

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Gene Therapy, 2019
Self-amplifying RNA (saRNA) is a promising biotherapeutic tool that has been used as a vaccine against both infectious diseases and cancer. saRNA has been shown to induce protein expression for up to 60 days and elicit immune responses with lower dosing ...
A. Blakney, P. Mckay, Bárbara Ibarzo Yus, Y. Aldon, R. Shattock   +4 more
semanticscholar   +2 more sources

Phosphatidylcholine-Polysorbate 20-Based Mixed Micelles: A New Option to Prevent Protein Aggregation?

Pharmaceutics
Background/Objectives: Surfactants are commonly used to protect proteins from denaturation and particle formation, thereby ensuring the long-term stability of biopharmaceuticals.
Johanna Weber, Tim Diederichs, Lukas Bollenbach, Patrick Garidel, Karsten Mäder   +4 more
doaj   +1 more source

Biotherapeutic Formulation Factors Affecting Metal Leachables from Stainless Steel Studied by Design of Experiments [PDF]

AAPS PharmSciTech, 2012
Trace amounts of metals are inevitably present in biotherapeutic products. They can arise from various sources. The impact of common formulation factors such as protein concentration, antioxidant, metal chelator concentration and type, surfactant, pH, and contact time with stainless steel on metal leachables was investigated by a design of experiments ...
Shuxia, Zhou, Brad, Evans, Christian, Schöneich, Satish K, Singh   +3 more
openaire   +2 more sources

Cyanobacterial Production of Biopharmaceutical and Biotherapeutic Proteins

Frontiers in Plant Science, 2020
Efforts to express human therapeutic proteins in photosynthetic organisms have been described in the literature. Regarding microalgae, most of the research entailed a heterologous transformation of the chloroplast, but transformant cells failed to ...
Nico Betterle, Diego Hidalgo Martinez, A. Melis   +2 more
semanticscholar   +1 more source

Preclinical development of epicertin, a novel biotherapeutic for the treatment of ulcerative colitis.

, 2021
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Micaela A. Reeves
semanticscholar   +1 more source

Detergent/surfactant retention during ultrafiltration in the formulation of biotherapeutics

Biotechnology Progress
Abstract Surfactants like polysorbate (Tween®) are commonly used as excipients in the production of monoclonal antibodies and other recombinant proteins. The retention behavior of these excipients in the final ultrafiltration step can be difficult to predict due to the presence of both monomers and micelles.
Liang‐Kai Chu, Zhuoshi Du, Matthew Billups, Hee Jeung Oh, Andrew L. Zydney   +4 more
openaire   +2 more sources

Application status of royal jelly in the medical field

Journal of Functional Foods
Royal jelly (RJ), a representative product of food-medicine homology, possesses complex bioactive components including major royal jelly proteins (MRJPs) and 10-hydroxy-2-decenoic acid (10-HDA), contributing to its multifaceted pharmacological functions.
Jun-Hong Huang, Qian-Qian Wang, Shi-Yi Zhang, Chu-Yue Zhang, Yu Huang, Yan-Xia Feng, Shu-Ying Feng   +6 more
doaj   +1 more source

Encapsulated probiotics as antimicrobial agents: mechanisms and delivery strategies against multidrug-resistant pathogens

Frontiers in Cellular and Infection Microbiology
The rapid escalation of antimicrobial resistance (AMR) has rendered many conventional antibiotics ineffective, emphasizing the need for alternative therapeutic approaches.
Ulpan Kart, Dinara Smagulova, Dana Khairetdinova, Aigul Raimbekova, Gonzalo Hap Hortelano   +4 more
doaj   +1 more source

Development of a High-Cell-Density Production Process for a Biotherapeutic Yeast, Saccharomyces cerevisiae var. boulardii, for Use as a Human Probiotic

Fermentation
Saccharomyces cerevisiae var. boulardii is a probiotic yeast widely recognized for its ability to enhance gut health and modulate a host’s microbiome.
G. Moonsamy, Sarisha Singh, Yrielle Roets-Dlamini, Koketso Kenneth Baikgaki, S. Ramchuran   +4 more
semanticscholar   +1 more source

Development and Mechanistic Insights into Lyoprotective Technology for Akkermansia muciniphila Live Biotherapeutic Products

Shipin gongye ke-ji
To explore the optimal combination of lyoprotective agents for effectively enhancing the viability of Akkermansia muciniphila (Akk) and elucidating the underlying mechanisms.
Yuanzhi XU, Hongxiao SUN, Yanwei ZHANG, Ziyan HAN, Qinggang XIE, Xiaoxi XU   +5 more
doaj   +1 more source