Results 41 to 50 of about 1,949 (187)

Antimicrobial Activity of Polysorbate 80-iodine Complex: Polysorbate 80 Firmly Retains Iodine

Journal of Oleo Science, 2022
Considering that iodine is highly volatile and has low solubility in water, it is utilized as an antiseptic in its complex form (iodophor) with a carrier material. Herein, we prepared the polysorbate 80-iodine complex and investigated its properties.
Yano, Shigekazu, Terada, Senri, Fukushi, Misaki, Otsuka, Yuitsu, Mizunuma, Satomi, Asakura, Satoshi, Kawai, Takahiro, Konno, Hiroyuki, Endo, Masatoshi, Nonomura, Yoshimune   +9 more
openaire   +2 more sources

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Tuning Colloidal Stability and Photothermal Conversion Efficiency of Graphite Nanofluids via Anionic‐Nonionic Surfactant Engineering

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Graphite nanofluids were stabilized using a mixed SDS/Tween 80 surfactant system. The optimized formulation exhibited enhanced colloidal stability, red‐shifted UV–Vis absorption, and improved photothermal conversion under solar irradiation. Achieving stable dispersion of graphite flakes (GFs) in aqueous media remains a critical challenge in developing ...
Ahmad Chehade, Shoaib Anwer, Md Islam, Eiyad Abu‐Nada   +3 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Scientific Opinion on the re‐evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives

EFSA Journal, 2015
The Panel on Food Additives and Nutrient Sources added to Food (ANS) re‐evaluated the safety of polysorbate 20 (E 432), polysorbate 80 (E 433), polysorbate 40 (E 434), polysorbate 60 (E 435) and polysorbate 65 (E 436) as food additives.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
doaj   +1 more source

Immune-Mediated Organ-Specific Reactions to COVID-19 Vaccines: A Retrospective Descriptive Study

Pharmaceuticals, 2023
Severe acute respiratory syndrome coronavirus 2 caused the global COVID-19 pandemic and public health crisis, and it led to the rapid development of COVID-19 vaccines, which can cause rare and typically mild hypersensitivity reactions (HRs).
Carmen Ruiz-Fernández, Ricardo Cuesta, Susana Martín-López, Javier Guijarro, Arturo López Gómez de las Huertas, Mikel Urroz, Laura Miguel-Berenguel, Miguel González-Muñoz, Elena Ramírez   +8 more
doaj   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source

Delayed diagnosis of hereditary fructose intolerance presenting as chronic lean steatosis in an adolescent

JPGN Reports, EarlyView.
Abstract Hereditary fructose intolerance (HFI) typically presents in infancy with acute metabolic crisis upon the introduction of fructose. We report a case of a 13‐year‐old female with chronic abdominal pain, short stature, and persistent mild transaminitis.
Alexandra Hurlock, Melissa Lah, Hannah Sue Hyaduck, Jean P. Molleston, Chaowapong Jarasvaraparn   +4 more
wiley   +1 more source

Dose–response modelling uncovers compound‐specific inhibitory effects of host defence volatiles on mountain pine beetle fungal symbionts

Pest Management Science, EarlyView.
Host defence volatiles inhibit mountain pine beetle fungal symbionts in a compound‐ and enantiomer‐specific manner, with distinct dose–response profiles that reveal the multitarget chemical defences of beetle–fungi symbiotes. Abstract BACKGROUND The mountain pine beetle relies on symbiotic fungi to overcome host tree defences, yet these fungi must ...
Duo Zhang, Yanzhuo Liu, Xinyi Zhao, Guncha Ishangulyyeva, Nadir Erbilgin   +4 more
wiley   +1 more source