Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation
Pharmaceutics, 2023 The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality.
Karsten Maeder +2 more
exaly +6 more sources
The effect of polysorbate 20 and polysorbate 80 on the solubility of quercetin
Journal of Public Health in Africa, 2023 Background: Quercetin acts as an antioxidant, anti-inflammatory, wound healing, and anti-aging so quercetin can be used as a topical preparation. However, it has low solubility in water at 0.01 mg/ml at 25°C.
Tristiana Erawati +2 more
doaj +3 more sources
Effects of Selected Polysorbate and Sucrose Ester Emulsifiers on the Physicochemical Properties of Astaxanthin Nanodispersions [PDF]
Molecules, 2013 The effects of selected nonionic emulsifiers on the physicochemical characteristics of astaxanthin nanodispersions produced by an emulsification/evaporation technique were studied.
Navideh Anarjan, Chin Ping Tan
doaj +5 more sources
Immunological Considerations of Polysorbate as an Excipient in Botulinum Neurotoxin Type A Formulations: A Narrative Review [PDF]
ToxinsRecent botulinum neurotoxin type A (BoNT/A) formulations have shifted towards the use of polysorbate 20 (PS20) and polysorbate 80 (PS80) as a non-human-derived excipient to enhance product stability.
Michael Uwe Martin +5 more
doaj +2 more sources
Extraction of the polysorbate 20 and 80 fingerprint via generative modeling [PDF]
International Journal of Pharmaceutics: XPolysorbate 20 (PS20) and polysorbate 80 (PS80) are essential surfactants used to stabilize biopharmaceutical products, yet their highly heterogeneous mixtures and susceptibility to oxidation and enzymatic hydrolysis complicate routine analysis.
Peter Roelants +6 more
doaj +2 more sources
Safety of Polysorbate 80 in the Oncology Setting [PDF]
Advances in Therapy, 2018 Polysorbate 80 is a synthetic nonionic surfactant used as an excipient in drug formulation. Various products formulated with polysorbate 80 are used in the oncology setting for chemotherapy, supportive care, or prevention, including docetaxel, epoetin/darbepoetin, and fosaprepitant.
Lee S Schwartzberg, Rudolph M Navari
exaly +3 more sources
Oxidation of polysorbates – An underestimated degradation pathway?
International Journal of Pharmaceutics: X, 2023 To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active compounds (surfactants) are added to protect biologics from denaturation and particle formation.
Johanna Weber +4 more
doaj +5 more sources
Pharmaceutics, 2023 P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms.
Rasmus Blaaholm Nielsen +5 more
doaj +1 more source
Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy
Applied Sciences, 2021 Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives.
Vasanthan Ravichandran +3 more
doaj +1 more source
Delayed local reaction at a previous injection site reaction with dupilumab
Respirology Case Reports, 2021 Key message Clinicians should be aware that biologic agents, which include polysorbates, can cause delayed local skin reactions at a previous injection site.
Toshiyuki Sumi +6 more
doaj +1 more source