Results 1 to 10 of about 249,969 (116)

Effects of Different Polysorbates (Tween) on Recombined Whipped Cream: Interfacial Properties, Stability, and Aeration Properties. [PDF]

Foods
Emulsifiers play a crucial role in improving the shelf-life stability and aeration quality of recombined whipped cream (RDC). This study systematically investigated the interfacial adsorption behaviors of four types of polysorbates (Tween20, Tween40 ...
Zuo Y, Yan G, Wang Y, Li Y.
europepmc   +2 more sources

Immunological Considerations of Polysorbate as an Excipient in Botulinum Neurotoxin Type A Formulations: A Narrative Review. [PDF]

Toxins (Basel)
Recent botulinum neurotoxin type A (BoNT/A) formulations have shifted towards the use of polysorbate 20 (PS20) and polysorbate 80 (PS80) as a non-human-derived excipient to enhance product stability.
Martin MU, Frevert J, Park JY, Cui H, Curry A, Loh WQ.   +5 more
europepmc   +2 more sources

Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation

Pharmaceutics, 2023
The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality.
Patrick Garidel, Karsten Mader, Julia Buske   +2 more
exaly   +3 more sources

Extraction of the polysorbate 20 and 80 fingerprint via generative modeling. [PDF]

Int J Pharm X
Polysorbate 20 (PS20) and polysorbate 80 (PS80) are essential surfactants used to stabilize biopharmaceutical products, yet their highly heterogeneous mixtures and susceptibility to oxidation and enzymatic hydrolysis complicate routine analysis.
Roelants P, Choubeh RR, Verbeeck N, Andujar R, Schultz-Fademrecht T, Garidel P, Gross V.   +6 more
europepmc   +2 more sources

The effect of polysorbate 20 and polysorbate 80 on the solubility of quercetin

Journal of Public Health in Africa, 2023
Background: Quercetin acts as an antioxidant, anti-inflammatory, wound healing, and anti-aging so quercetin can be used as a topical preparation. However, it has low solubility in water at 0.01 mg/ml at 25°C.
Tristiana Erawati, Dewi Isadiartuti, Bintari D. Anggalih   +2 more
doaj   +1 more source

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Applied Sciences, 2021
Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives.
Vasanthan Ravichandran, Minjong Lee, Thuy Giang Nguyen Cao, Min Suk Shim   +3 more
doaj   +1 more source

Delayed local reaction at a previous injection site reaction with dupilumab

Respirology Case Reports, 2021
Key message Clinicians should be aware that biologic agents, which include polysorbates, can cause delayed local skin reactions at a previous injection site.
Toshiyuki Sumi, Yuta Nagahisa, Keigo Matsuura, Motoki Sekikawa, Yuichi Yamada, Hisashi Nakata, Hirofumi Chiba   +6 more
doaj   +1 more source

Optimization of Emulsification Conditions on Ethanol Extract of Taiwanese Green Propolis Using Polysorbate and Its Immunomodulatory Effects in Broilers

Animals, 2022
Beeswax and resin are the main components of propolis, both of which are hydrophobic. The use of emulsifiers helps to improve the extraction of active propolis compounds and makes them more widely used.
Felix Shih-Hsiang Hsiao, Clara Ajeng Artdita, Kuo-Feng Hua, Chia-Jung Tsai, Yi-Hsuan Chien, Yue-Wen Chen, Yeong-Hsiang Cheng, Yu-Hsiang Yu   +7 more
doaj   +1 more source

Polysorbates versus Hydroxypropyl Beta-Cyclodextrin (HPβCD): Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies

Molecules, 2022
Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and surface adsorption.
Hailong Zhang, Shiqi Hong, Sarah Si Kai Tan, Tao Peng, Lucas Yuan Hao Goh, Kwan Hang Lam, Keat Theng Chow, Rajeev Gokhale   +7 more
doaj   +1 more source

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Pharmaceutics, 2023
P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms.
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen   +5 more
doaj   +1 more source