Results 31 to 40 of about 250,055 (193)

Interface Compositions as Determinants of Resveratrol Stability in Nanoemulsion Delivery Systems

Foods, 2020
The incorporation of hydrophobic ingredients, such as resveratrol (a fat-soluble phytochemical), in nanoemulsions can increase the water solubility and stability of these hydrophobic ingredients.
Adela Mora-Gutierrez, Rahmat Attaie, Maryuri T. Núñez de González, Yoonsung Jung, Sixto A. Marquez   +4 more
doaj   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Effect of adding magnesium salts or different emulsifiers to a fatty acid prill on fatty acid digestibility and milk fat production in lactating dairy cows

Journal of Dairy Science
: Fatty acid (FA) supplements are commonly fed to increase the energy content of lactating dairy cow diets and improve milk and milk fat yield and energy balance. However, increasing dietary fat commonly decreases FA digestibility.
S.L. Burtnett, Y. Adeniji, J. Albrecht, O.R. Drehmel, P. Yoder, M.F. Scott, K.J. Harvatine   +6 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping

International Journal of Pharmaceutics: X, 2022
Polysorbates are an important class of nonionic surfactants that are widely used to stabilize biopharmaceuticals. The degradation of polysorbate 20 and 80 and the related particle formation in biologics are heavily discussed in the pharmaceutical ...
Judith J. Mittag, Marie-Luise Trutschel, Helen Kruschwitz, Karsten Mäder, Julia Buske, Patrick Garidel   +5 more
doaj   +1 more source

Antimicrobial Activity of Polysorbate 80-iodine Complex: Polysorbate 80 Firmly Retains Iodine

Journal of Oleo Science, 2022
Considering that iodine is highly volatile and has low solubility in water, it is utilized as an antiseptic in its complex form (iodophor) with a carrier material. Herein, we prepared the polysorbate 80-iodine complex and investigated its properties.
Yano, Shigekazu, Terada, Senri, Fukushi, Misaki, Otsuka, Yuitsu, Mizunuma, Satomi, Asakura, Satoshi, Kawai, Takahiro, Konno, Hiroyuki, Endo, Masatoshi, Nonomura, Yoshimune   +9 more
openaire   +2 more sources

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Analysis of Polysorbate-Degrading Esterase Residues in Therapeutic Antibodies by Mass Spectrometry

Zhipu Xuebao
Polysorbates are a class of hydrophilic non-ionic surfactants characterized by exceptional biocompatibility, rendering them the most frequently employed excipients in therapeutic monoclonal antibodies’ formulations. These compounds play a pivotal role in
Xiao-juan YU, Fei-yu WANG, Jia-ling ZHANG, Lan WANG, Chuan-fei YU   +4 more
doaj   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Foam Structure Preservation during Microwave-Assisted Vacuum Drying: Significance of Interfacial and Dielectric Properties of the Bulk Phase of Foams from Polysorbate 80–Maltodextrin Dispersions

Foods, 2021
This study aimed at examining the cause of differences in the structure preservation of polysorbate 80–maltodextrin foams during microwave-assisted vacuum drying (MWVD) versus conventional vacuum drying (CVD). Aqueous dispersions of 3% polysorbate 80 and
Peter Kubbutat, Ulrich Kulozik, Jannika Dombrowski   +2 more
doaj   +1 more source