Results 11 to 20 of about 250,055 (193)
Saudi Pharmaceutical Journal, 2020 The amount of polysorbate 80 in pharmaceutical formulations affects the product quality and efficacy. A reliable test method is required to quantify the amount of Polysorbate 80 present in the drug product formulations.
Bikash Mondal +3 more
doaj +1 more source
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms
mAbs, 2022 Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe.
Elizabeth Sara Hecht +11 more
doaj +1 more source
Evaluation of Patients with Vaccine Allergies Prior to mRNA-Based COVID-19 Vaccination
Vaccines, 2022 During the initial rollout of coronavirus disease 2019 (COVID-19) vaccination in Singapore, the Ministry of Health (MOH) issued a recommendation that patients with a history of any previous vaccine allergy be referred to an allergist for further review ...
Xin Rong Lim +12 more
doaj +1 more source
Тонкие химические технологии, 2020 Objectives. We hereby describe an improvement of a previously developed quantification technique for polysorbate 80 in biopharmaceutical formulations (darbepoetin alfa and eculizumab) and report the validation of the new approach.Methods. Polysorbate was
A. S. Seregin +4 more
doaj +1 more source
Polysorbate 80 blocked a peripheral sodium channel, Na1.7, and reduced neuronal excitability
Molecular Pain, 2023 Polysorbate 80 is a non-ionic detergent derived from polyethoxylated sorbitan and oleic acid. It is widely used in pharmaceuticals, foods, and cosmetics as an emulsifier. Na v 1.7 is a peripheral sodium channel that is highly expressed in sympathetic and
Ryeong-Eun Kim, Jin-Sung Choi
doaj +1 more source
Pharmaceuticals, 2018 Polyethylene glycol (PEG) is an inert, water soluble polymer, used for decades in pharmaceuticals. Although PEG is considered safe, concerns persist about the potential adverse effects of long-term exposure to PEG-containing therapies, specifically in ...
Reinhard Stidl +5 more
doaj +1 more source
Vaccines, 2023 Concern has arisen about hypersensitivity reactions in patients with allergic reactions to drugs containing polyethylene glycol (PEG) or polysorbate 80 (PS80), excipients of currently available anti-SARS-CoV-2 mRNA vaccines.
Emanuele Nappi +12 more
doaj +1 more source
Pharmaceutics, 2022 Glaucoma is a wide-spread eye disease caused by elevated intraocular pressure. Uncontrolled, this pressure may lead to damages to the optic nerve. Prostaglandin analogues, such as latanoprost and travoprost (which are water-insoluble active substances ...
Gabriel Alviset +6 more
doaj +1 more source
The influence of membrane composition on the release of polyphenols from liposomes [PDF]
Hemijska Industrija, 2015 Polyphenols are compound which are widely studied because of their antioxidative and potential therapeutic properties. Systems for the controlled release of drugs offer a number of benefits comparing with traditional forms of medicines and ...
Pravilović Radoslava N. +4 more
doaj +1 more source
Oxidation of polysorbates – An underestimated degradation pathway?
International Journal of Pharmaceutics: X, 2023 To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active compounds (surfactants) are added to protect biologics from denaturation and particle formation.
Johanna Weber +4 more
doaj +1 more source