Results 11 to 20 of about 257,706 (241)

Optimization of Emulsification Conditions on Ethanol Extract of Taiwanese Green Propolis Using Polysorbate and Its Immunomodulatory Effects in Broilers

open access: yesAnimals, 2022
Beeswax and resin are the main components of propolis, both of which are hydrophobic. The use of emulsifiers helps to improve the extraction of active propolis compounds and makes them more widely used.
Felix Shih-Hsiang Hsiao   +7 more
doaj   +1 more source

Polysorbates versus Hydroxypropyl Beta-Cyclodextrin (HPβCD): Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies

open access: yesMolecules, 2022
Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and surface adsorption.
Hailong Zhang   +7 more
doaj   +1 more source

Development of a simple high performance liquid chromatography (HPLC)/evaporative light scattering detector (ELSD) method to determine Polysorbate 80 in a pharmaceutical formulation

open access: yesSaudi Pharmaceutical Journal, 2020
The amount of polysorbate 80 in pharmaceutical formulations affects the product quality and efficacy. A reliable test method is required to quantify the amount of Polysorbate 80 present in the drug product formulations.
Bikash Mondal   +3 more
doaj   +1 more source

Symurban Nanocrystals for Advanced Anti-Pollution Skincare [PDF]

open access: yes, 2020
Several of most common dermatoses worldwide, e.g., psoriasis and atopic dermatitis, are worsened in their clinical picture when the skin is regularly exposed to an increased air pollution level, e.g., particulate matter.
Köpke, Daniel, Pyo, Sung Min
core   +1 more source

Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

open access: yesmAbs, 2022
Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe.
Elizabeth Sara Hecht   +11 more
doaj   +1 more source

Evaluation of Patients with Vaccine Allergies Prior to mRNA-Based COVID-19 Vaccination

open access: yesVaccines, 2022
During the initial rollout of coronavirus disease 2019 (COVID-19) vaccination in Singapore, the Ministry of Health (MOH) issued a recommendation that patients with a history of any previous vaccine allergy be referred to an allergist for further review ...
Xin Rong Lim   +12 more
doaj   +1 more source

Polysorbate 80 blocked a peripheral sodium channel, Na1.7, and reduced neuronal excitability

open access: yesMolecular Pain, 2023
Polysorbate 80 is a non-ionic detergent derived from polyethoxylated sorbitan and oleic acid. It is widely used in pharmaceuticals, foods, and cosmetics as an emulsifier. Na v 1.7 is a peripheral sodium channel that is highly expressed in sympathetic and
Ryeong-Eun Kim, Jin-Sung Choi
doaj   +1 more source

Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets [PDF]

open access: yes, 2016
We have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus. Here we show that the formulation of peptides LL37 and magainin-2B amide in polysorbate 20 (Tween-20™) results in greater reductions in virus ...
Beck, Konrad   +4 more
core   +2 more sources

Quantification of polysorbate 80 in biopharmaceutical formulations implementing an optimized colorimetric approach

open access: yesТонкие химические технологии, 2020
Objectives. We hereby describe an improvement of a previously developed quantification technique for polysorbate 80 in biopharmaceutical formulations (darbepoetin alfa and eculizumab) and report the validation of the new approach.Methods. Polysorbate was
A. S. Seregin   +4 more
doaj   +1 more source

Development of a Potentiometric Sensor Sensitive to Polysorbate 20 [PDF]

open access: yes, 2019
Polyoxyethylated sorbitans (polysorbates) are widely used in the chemical, pharmaceutical, and cosmetic industries, but only quantitative determination is used mainly for chromatographic methods.
Kotok, V. (Valerii)   +4 more
core   +2 more sources

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