Results 41 to 50 of about 250,055 (193)

Tuning Colloidal Stability and Photothermal Conversion Efficiency of Graphite Nanofluids via Anionic‐Nonionic Surfactant Engineering

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Graphite nanofluids were stabilized using a mixed SDS/Tween 80 surfactant system. The optimized formulation exhibited enhanced colloidal stability, red‐shifted UV–Vis absorption, and improved photothermal conversion under solar irradiation. Achieving stable dispersion of graphite flakes (GFs) in aqueous media remains a critical challenge in developing ...
Ahmad Chehade, Shoaib Anwer, Md Islam, Eiyad Abu‐Nada   +3 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling

British Journal of Pharmacy, 2022
The aim of this study was to optimise processing parameters in the preparation of budesonide nanocrystals by a miniature media milling process performed at labscale.
Rebecca Olubi, William Small, Jonathan Burley, Cynthia Bosquillon   +3 more
doaj   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source

DETERMINATION OF POLYSORBATES BY SPECTROPHOTOMETRY IN DRUGS BASED ON RECOMBINANT PROTEINS

Разработка и регистрация лекарственных средств, 2019
Method of determination of polysorbate 20 and polysorbate 80 in recombinant protein drugs based on spectrophotometry has been designed. Isolation of polysorbate from solution is carried out by solid phase extraction followed by elution of polysorbate ...
A. D. Askretkov, P. M. Isaykina, S. A. Cherepushkin, N. V. Orlova   +3 more
doaj  

Delayed diagnosis of hereditary fructose intolerance presenting as chronic lean steatosis in an adolescent

JPGN Reports, EarlyView.
Abstract Hereditary fructose intolerance (HFI) typically presents in infancy with acute metabolic crisis upon the introduction of fructose. We report a case of a 13‐year‐old female with chronic abdominal pain, short stature, and persistent mild transaminitis.
Alexandra Hurlock, Melissa Lah, Hannah Sue Hyaduck, Jean P. Molleston, Chaowapong Jarasvaraparn   +4 more
wiley   +1 more source

Dose–response modelling uncovers compound‐specific inhibitory effects of host defence volatiles on mountain pine beetle fungal symbionts

Pest Management Science, EarlyView.
Host defence volatiles inhibit mountain pine beetle fungal symbionts in a compound‐ and enantiomer‐specific manner, with distinct dose–response profiles that reveal the multitarget chemical defences of beetle–fungi symbiotes. Abstract BACKGROUND The mountain pine beetle relies on symbiotic fungi to overcome host tree defences, yet these fungi must ...
Duo Zhang, Yanzhuo Liu, Xinyi Zhao, Guncha Ishangulyyeva, Nadir Erbilgin   +4 more
wiley   +1 more source

Pediatric Safety of Polysorbates in Drug Formulations [PDF]

Children, 2019
Polysorbates 20 and 80 are the most frequently used excipients in biotherapeutics, the safety data for which have been well documented in adults. The polysorbate content in therapeutic formulations that are administered to children, however, has been less clearly regulated or defined with regard to safety.
Kriegel, Christina, Festag, Matthias, Kishore, Ravuri S.K., Roethlisberger, Dieter, Schmitt, Georg   +4 more
openaire   +2 more sources

Salvianolic Acid C Protects Against Hepatic Ischemia–Reperfusion Injury via Heat Shock Protein 90α‐Mediated Activation of the Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling Pathway

Phytotherapy Research, EarlyView.
Salvianolic acid C (SaC) protects against hepatic ischemia–reperfusion injury (HIRI) by upregulating HSP90α and activating the PI3K/AKT pathway, thereby alleviating oxidative stress, inflammation, apoptosis, and necrosis. ABSTRACT Hepatic ischemia–reperfusion injury (HIRI) is a major challenge in liver surgery, and effective pharmacological ...
Pingping Qiao, Alimu Tulahong, Xinlu Xu, Tiemin Jiang, Ruiqing Zhang, Yanze Lin, Zhongdian Yuan, Rexiati Ruze, Yingmei Shao   +8 more
wiley   +1 more source

Climate‐Modulated Particle Toxicity: Acute Exposure to an Environmentally Informed Microplastic Mixture Induces Sex‐Dependent Systemic Reorganization in Swiss Mice

Environmental Toxicology, EarlyView.
ABSTRACT Microplastic (MP) pollution is widely recognized as an emerging environmental threat. Yet, most studies still rely on controlled experimental conditions that poorly reflect environmental complexity, potentially underestimating risks under realistic scenarios, particularly during short‐term exposures. Here, we tested whether acute oral exposure
Guilherme Malafaia, Rafaela Ribeiro de Brito, Aline Sueli de Lima de Rodrigues, Omar Cruz Santiago, Andrés Hugo Arias, Thiarlen Marinho da Luz   +5 more
wiley   +1 more source