Results 21 to 30 of about 1,949 (187)

KINETICS OF ASPIRIN HYDROLYSIS IN AQUEOUS SOLUTION OF SURFACTANTS I- NON-IONIC SURFACTANTS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1986
The kinetics of aspirin hydrolysis were studied in the presence of different concentrations of polysorbates and at a variety of pH range. The aspirin hydrolysis in the presence of polysorbates followed first-order kinetics and the observed rate constants
A. Simonelli, S. Ismail
doaj   +1 more source

INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES: V- THERMODYNAMICS OF TEMAZEPAM SOLUBILIZATION [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1988
Temazepam was solubilized by series of non-ionic surfactant solutions including polysorbates, Eumulgins, Brjs, Myrjs and cetomacrogol as well as ionic ones including sodium lauryl sulphate and cetrimide at different temperatures.
S. Ahmed, Aly Abdel Rahman, A. Aboutaleb, B. Mulley   +3 more
doaj   +1 more source

Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping

International Journal of Pharmaceutics: X, 2022
Polysorbates are an important class of nonionic surfactants that are widely used to stabilize biopharmaceuticals. The degradation of polysorbate 20 and 80 and the related particle formation in biologics are heavily discussed in the pharmaceutical ...
Judith J. Mittag, Marie-Luise Trutschel, Helen Kruschwitz, Karsten Mäder, Julia Buske, Patrick Garidel   +5 more
doaj   +1 more source

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Applied Sciences, 2021
Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives.
Vasanthan Ravichandran, Minjong Lee, Thuy Giang Nguyen Cao, Min Suk Shim   +3 more
doaj   +1 more source

Comparison of the NMR and the Acid Value Determination Methods for Quality Control of Input Polysorbates

Acta Chimica Slovenica, 2019
Polysorbates (PS) are the most common non-ionic surfactants used in protein formulations. Their degradation has been studied intensively in recent years.
Ema Valentina Brovč, Stane Pajk, Roman Šink, Janez Mravljak   +3 more
doaj   +1 more source

Allergy to polyethylene glycol and polysorbates in a patient cohort: Diagnostic work‐up and decision points for vaccination during the COVID‐19 pandemic

Clinical and Translational Allergy, 2022
Background During the COVID‐19 pandemic focus has been on polyethylene glycol (PEG) and polysorbate as these excipients are constituents in the first vaccines and possible elicitors of allergic reactions to the vaccines.
Charlotte G. Mortz, Henrik F. Kjaer, Trine H. Rasmussen, Helene M. Rasmussen, Lene Heise Garvey, Carsten Bindslev‐Jensen   +5 more
doaj   +1 more source

Case of Polyethylene Glycol Allergy Confirmed with Basophil Activation Test and Oral Challenge Successfully Immunized with SARS-CoV-2 Vaccine

Iranian Journal of Allergy, Asthma and Immunology, 2023
Polyethylene glycols (PEG) or macrogols are polymers of ethylene oxide widely used in drugs either as active substances or, more commonly, as excipients.
Maria Pasali, Styliani Taka, Caterina Chliva, Alexandros Katoulis, Michael Makris   +4 more
doaj   +1 more source

Comparison of rumen and abomasal infusions of an exogenous emulsifier on fatty acid digestibility of lactating dairy cows

Journal of Dairy Science, 2023
: We evaluated the effects of infusing an exogenous emulsifier (polysorbates-C18:1) either into the rumen or abomasum on fatty acid (FA) digestibility and production responses of lactating dairy cows.
J.M. dos Santos Neto, C.M. Prom, A.L. Lock   +2 more
doaj   +1 more source

Effects of emulsifiers on the moisture sorption and crystallization of amorphous sucrose lyophiles

Food Chemistry: X, 2019
The crystallization of amorphous sucrose can be problematic in food products. This study explored how emulsifiers (a range of sucrose esters, polysorbates, and soy lecithin) impact the moisture sorption and crystallization of amorphous sucrose lyophiles.
Adrienne L. Voelker, Gianna Verbeek, Lynne S. Taylor, Lisa J. Mauer   +3 more
doaj   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source