Results 21 to 30 of about 9,191 (255)
Effect of Polysorbates on Solids Wettability and Their Adsorption Properties
Colloids and Interfaces, 2018 The wettability of solids is important from both practical and theoretical viewpoints. In this study, we measured the contact angle of aqueous solutions of polysorbates (Tween 20, Tween 60, and Tween 80) on polytetrafluoroethylene (PTFE), polyethylene ...
Katarzyna Szymczyk +2 more
exaly +2 more sources
Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern
Journal of Excipients and Food Chemicals, 2016 Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
doaj +2 more sources
FAMS—A Targeted Fatty Acid Mass Spectrometry Method for Monitoring Free Fatty Acids from Polysorbate Hydrolysis [PDF]
Methods and ProtocolsPolysorbates are the predominant surfactants used to stabilize protein formulations. Unfortunately, polysorbates can undergo hydrolytic degradation, which releases fatty acids that can accumulate to form visible particles.
Anja Bathke +4 more
doaj +2 more sources
Polysorbates’ effects on molecular and thermodynamic properties of phosphorodiamidate morpholino oligonucleotides’ structures [PDF]
Molecular Therapy: Nucleic AcidsElucidating the structure-function relationships of phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to limited structural data.
Evgenii Kliuchnikov +6 more
doaj +2 more sources
Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota
Foods, 2022 The use of emulsifiers in processed foods and the rapid epidemic development of metabolic syndrome in Western countries over the past 20 years have generated growing interest.
Martina De Siena +7 more
doaj +1 more source
The effect of polysorbate 20 and polysorbate 80 on the solubility of quercetin
Journal of Public Health in Africa, 2023 Background: Quercetin acts as an antioxidant, anti-inflammatory, wound healing, and anti-aging so quercetin can be used as a topical preparation. However, it has low solubility in water at 0.01 mg/ml at 25°C. Increasing the solubility of quercetin in water was done by the addition of surfactants.
Tristiana Erawati +2 more
openaire +3 more sources
Journal of Pharmacy and Science, 2023 Therapeutic proteins and antibodies are exposed to a variety of interfaces during their lifecycle, which can compromise their stability. Formulations, including surfactants, must be carefully optimized to improve interfacial stability against all types ...
Dominik Zürcher +5 more
semanticscholar +1 more source
Anaphylactic Reactions to COVID-19 Vaccines: An Updated Assessment Based on Pharmacovigilance Data
Vaccines, 2023 This study aimed at producing an updated assessment of the incidence of anaphylaxis associated with COVID-19 vaccines based on pharmacovigilance data. Anaphylactic reaction and anaphylactic shock data post-COVID-19-vaccination reported from week 52, 2020
Fotini Boufidou +7 more
doaj +1 more source
Journal of Pharmacy and Science, 2022 Polysorbate (PS) 20 and 80 are the main surfactants used to stabilize biopharmaceutical products. Industry practices on various aspects of PS based on a confidential survey and following discussions by 16 globally acting major biotechnology companies is ...
K. Wuchner +18 more
semanticscholar +1 more source
Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]
, 2019 Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl +6 more
core +1 more source