Results 51 to 60 of about 1,949 (187)

Pediatric Safety of Polysorbates in Drug Formulations [PDF]

Children, 2019
Polysorbates 20 and 80 are the most frequently used excipients in biotherapeutics, the safety data for which have been well documented in adults. The polysorbate content in therapeutic formulations that are administered to children, however, has been less clearly regulated or defined with regard to safety.
Kriegel, Christina, Festag, Matthias, Kishore, Ravuri S.K., Roethlisberger, Dieter, Schmitt, Georg   +4 more
openaire   +2 more sources

Salvianolic Acid C Protects Against Hepatic Ischemia–Reperfusion Injury via Heat Shock Protein 90α‐Mediated Activation of the Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling Pathway

Phytotherapy Research, EarlyView.
Salvianolic acid C (SaC) protects against hepatic ischemia–reperfusion injury (HIRI) by upregulating HSP90α and activating the PI3K/AKT pathway, thereby alleviating oxidative stress, inflammation, apoptosis, and necrosis. ABSTRACT Hepatic ischemia–reperfusion injury (HIRI) is a major challenge in liver surgery, and effective pharmacological ...
Pingping Qiao, Alimu Tulahong, Xinlu Xu, Tiemin Jiang, Ruiqing Zhang, Yanze Lin, Zhongdian Yuan, Rexiati Ruze, Yingmei Shao   +8 more
wiley   +1 more source

Climate‐Modulated Particle Toxicity: Acute Exposure to an Environmentally Informed Microplastic Mixture Induces Sex‐Dependent Systemic Reorganization in Swiss Mice

Environmental Toxicology, EarlyView.
ABSTRACT Microplastic (MP) pollution is widely recognized as an emerging environmental threat. Yet, most studies still rely on controlled experimental conditions that poorly reflect environmental complexity, potentially underestimating risks under realistic scenarios, particularly during short‐term exposures. Here, we tested whether acute oral exposure
Guilherme Malafaia, Rafaela Ribeiro de Brito, Aline Sueli de Lima de Rodrigues, Omar Cruz Santiago, Andrés Hugo Arias, Thiarlen Marinho da Luz   +5 more
wiley   +1 more source

Safety of Polysorbate 80 in the Oncology Setting [PDF]

Advances in Therapy, 2018
Polysorbate 80 is a synthetic nonionic surfactant used as an excipient in drug formulation. Various products formulated with polysorbate 80 are used in the oncology setting for chemotherapy, supportive care, or prevention, including docetaxel, epoetin/darbepoetin, and fosaprepitant.
Lee S. Schwartzberg, Rudolph M. Navari
openaire   +2 more sources

The BioSAXS laboratory of the ITACA.SB Research Infrastructure

Journal of Applied Crystallography, EarlyView.
We present a versatile state‐of‐the‐art X‐ray scattering laboratory within the ITACA.SB Research Infrastructure, enabling multi‐scale structural characterization of complex biological specimens and advanced materials through integrated small‐ and wide‐angle X‐ray scattering (SAXS/WAXS) techniques.
Francesco Scattarella, Davide Altamura, Vincenzo Mangini, Teresa Sibillano, Erika Manicone, Rocco Lassandro, Liberato De Caro, Gemma Newby, Cinzia Giannini   +8 more
wiley   +1 more source

Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern [PDF]

Journal of Excipients and Food Chemicals
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
doaj  

Behavioural responses of peach potato aphid, Myzus persicae Sulzer (Hemiptera: Aphididae), to entomopathogenic fungi infected conspecifics

Agricultural and Forest Entomology, EarlyView.
Myzus persicae showed no detectable behavioural response to Beauveria bassiana‐colonised agar alone. Aphids spent significantly more time in odour fields containing EPF‐infected conspecifics than healthy aphids, agar or blank air. EPF infection may alter host‐associated odours, suggesting pathogen‐mediated cues could influence aphid behaviour and ...
Ben J. Clunie, Thomas Bluck, Imogen Crowe, Devan Coyne, Aidan Smith, Tom W. Pope, Joe M. Roberts   +6 more
wiley   +1 more source

The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk

Allergy, EarlyView.
ABSTRACT IgE‐mediated food allergy is a global health issue with rising prevalence that cannot be explained by genetic change alone, strongly suggesting that environmental exposures are a key driver. The external exposome encompasses several exposures that influence the developing immune system and modify food allergy risk.
Johanna M. Smeekens, Helen A. Brough, Kirsi M. Järvinen, Sophie Troyer, Michael D. Kulis, Timothy P. Moran   +5 more
wiley   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Potential of organogel‐based colloidal hydrogels for new cosmetic formulations

International Journal of Cosmetic Science, EarlyView.
Colloidal hydrogels are formed by combining anionic, cationic, or nonionic surfactants with two oils of cosmetic interest: sweet almond oil and phytosqualane. These systems are obtained through hot emulsification followed by cooling, which leads to the aggregation of gel‐like particles.
Andrea Gregorio Gomes, Lea Broche, Bruno Payre, Emile Perez, Celine Picard, Sophie Franceschi   +5 more
wiley   +1 more source