Results 61 to 70 of about 381,611 (334)
, 2018 Biotin-conjugated multistimuli-responsive polysaccharide vesicular nanocarriers are designed and developed, for the first time, to accomplish receptor-mediated endocytosis in cancer cells and to deliver anticancer drugs to intracellular compartments. For
Manickam Jayakannan (1443418) +1 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Genetic optimization of biotin-binding proteins : artificial metalloenzymes and beyond [PDF]
, 2010 The versatility of the biotin-(strept)avidin system has been exploited as important tool in a plethora of medical and biotechnological applications, including molecular detection, immobilization, protein purification, construction of supramolecular ...
Sardo, Alessia
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Pharmaceutics, 2020 Biotin receptors are overexpressed by various types of solid cancer cells and play a significant role in tumor metabolism, growth, and metastasis. Thus, targeting the biotin receptors on tumor cells may enhance the efficiency and reduce the side-effects ...
Endiries Yibru Hanurry +9 more
doaj +1 more source
Water-mediated green synthesis of PbS quantum dot and its glutathione and biotin conjugates for non-invasive live cell imaging [PDF]
Royal Society Open Science, 2018 This study addresses the cellular uptake of nanomaterials in the field of bio-applications. In the present study, we have synthesized water-soluble lead sulfide quantum dot (PbS QD) with glutathione and 3-MPA (mercaptopropionic acid) as the stabilizing ...
M. Vijaya Bharathi +4 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Synthetic and Systems BiotechnologyBiotin (vitamin B7) is a crucial cofactor for various metabolic processes and has significant applications in pharmaceuticals, cosmetics, and animal feed.
Yue Wu +7 more
doaj +1 more source
DIETARY SUPPLEMENTS THAT CONTAIN BIOTIN DO NOT INFLUENCE FLUORESCENCE THYROID-STIMULATING HORMONE VALUES WHEN SCREENING FOR CONGENITAL HYPOTHYROIDISM IN NEWBORNS [PDF]
, 2020 Background. Biotin levels may interfere with immunological tests that use biotin-streptavidin complexes. Although the recommended daily intake (RDI) of biotin is 30 μg, some dietary supplements that are available without prescription contain double or ...
Barbu, S.V. +11 more
core +1 more source