Results 41 to 50 of about 71,056 (300)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Photometallobiocatalytic Asymmetric Radical‐Mediated Cross‐Coupling of Organotrifluoroborate Salts and Pyridotriazoles

Angewandte Chemie, EarlyView.
An enantioselective photometallobiocatalytic cross‐coupling of pyridotriazoles and secondary alkyltrifluoroborate salts is developed. Cooperative catalysis using eosin B and an engineered protoglobin combines visible‐light‐mediated radical generation with enzymatic metal carbenoid activation, affording valuable N‐heterocyclic products in excellent ...
Huanan Wang, Binh Khanh Mai, Xingjie Zhang, Chongtao Li, Peng Liu, Yang Yang   +5 more
wiley   +2 more sources

A Crucial Role for Ergosterol in Plasma Membrane Composition, Localisation, and Activity of Cdr1p and H⁺-ATPase in Candida albicans

Microorganisms, 2019
Candida albicans is an opportunistic fungal pathogen of humans. Treatment of C. albicans infections relies on azoles, which target the lanosterol 14α-demethylase (Erg11p) encoded by the ERG11 gene.
Jakub Suchodolski, Jakub Muraszko, Przemysław Bernat, Anna Krasowska   +3 more
doaj   +1 more source

Comparison in antioxidant and antitumor activities of pine polyphenols and its seven biotransformation extracts by fungi [PDF]

PeerJ, 2017
Microbial transformation can strengthen the antioxidant and antitumor activities of polyphenols. Polyphenols contents, antioxidant and antitumor activities of pine polyphenols and its biotransformation extracts by Aspergillus niger, Aspergillus oryzae ...
Hui Li, Zhenyu Wang
doaj   +2 more sources

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Production of Cellulases by Trichoderma, Aspergillus, and Penicillium: Optimization Strategies, Biomass Valorization, and Industrial Perspectives

Biomass
Fungal cellulases are key biocatalysts for lignocellulosic biomass valorization and the development of sustainable biorefineries. This review examines recent advances in the production of endoglucanase (EGL), exoglucanase (EXG), and β-glucosidase (BGL ...
Isabela Viana Lopes de Moura, Sabryna Couto Araujo, Igor Carvalho Fontes Sampaio, Erik Galvão Paranhos da Silva, Marcelo Franco, Julieta Rangel de Oliveira   +5 more
doaj   +1 more source

Heterocycles 36. Single-Walled Carbon Nanotubes-Bound N,N-Diethyl Ethanolamine as Mild and Efficient Racemisation Agent in the Enzymatic DKR of 2-Arylthiazol-4-yl-alanines

Molecules, 2015
In this paper we describe the chemoenzymatic synthesis of enantiopure l-2-arylthiazol-4-yl alanines starting from their racemic N-acetyl derivatives; by combining the lipase-catalysed dynamic kinetic resolution of oxazol-5(4H)-ones with a chemical and an
Denisa Leonte, László Csaba Bencze, Csaba Paizs, Monica Ioana Toşa, Valentin Zaharia, Florin Dan Irimie   +5 more
doaj   +1 more source

Biotransformation of testosterone by Cladosporium sphaerospermum

, 2019
Incubation of testosterone 1 with Cladosporium sphaerospermum MRC 70266 afforded six metabolites and two of these metabolites, 6?,16?,17?-trihydroxyandrost-4-en-3-one 6 and 6?,12?,17?-trihydroxyandrost-4-en-3-one 7, were determined as new compounds.
Sengul Yilmaz, Kuru, Ali, Yıldırım, Kudret   +2 more
core   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Engineering Escherichia coli via introduction of the isopentenol utilization pathway to effectively produce geranyllinalool

Microbial Cell Factories
Background Geranyllinalool, a natural diterpenoid found in plants, has a floral and woody aroma, making it valuable in flavors and fragrances. Currently, its synthesis primarily depends on chemical methods, which are environmentally harmful and ...
Jin Chang, Xinduo Wei, Deyu Liu, Qian Li, Chong Li, Jianguo Zhao, Likun Cheng, Guanglu Wang   +7 more
doaj   +1 more source