Results 81 to 90 of about 62,756 (305)

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Metabolism (Biotransformation)

, 2014
Metabolism is the sum of all chemical reactions occurring in organisms at the cellular level to sustain life. The main purpose of metabolism is to convert food to energy to run cellular processes, build macromolecule building blocks, i.e., proteins ...
Saghir, Shakil Ahmed, Ansari, Rais Ahmad
core   +1 more source

Bioaccumulation and Biotransformation of Chlorinated Paraffins

, 2022
Chlorinated paraffins (CPs), a class of persistent, toxic, and bioaccumulated compounds, have received increasing attention for their environmental occurrence and ecological and human health risks worldwide in the past decades.
Bixian Mai, Luo, Xiaojun, Mai, Bixian, Liujun Chen, Xiaojun Luo, Chen, Liujun   +5 more
core   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Enhanced hairy root induction in garlic (Allium sativum L.) via Agrobacterium rhizogenes: Targeting the basal plate of intact sprout

Notulae Botanicae Horti Agrobotanici Cluj-Napoca
Hairy root induction in garlic represents a promising approach to actively exploit biomass from a familiar plant species rich in antibacterial compounds.
Phuong B.T. VU, Tan Q. TRAN, Khoi D. NGUYEN, Huy TRAN, Dai M. CAO, Phuong N.D. QUACH   +5 more
doaj   +1 more source

Trehalose Lipid Biosurfactant Reduces Adhesion of Microbial Pathogens to Polystyrene and Silicone Surfaces: An Experimental and Computational Approach

Frontiers in Microbiology, 2018
Rhodococcus fascians BD8, isolated from Arctic soil, was found to produce biosurfactant when grown on n-hexadecane as the sole carbon source. The glycolipid product was identified as the trehalose lipid with a molecular mass of 848 g mol−1.
Tomasz Janek, Anna Krasowska, Żaneta Czyżnikowska, Marcin Łukaszewicz   +3 more
doaj   +1 more source

A novel biotransformation process of 4'-demethylepipodophyllotoxin to 4'-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463, Part II: process optimization

, 2010
This work optimized the novel biotransformation process of 4'-demethylepipodophyllotoxin (DMEP) into 4'-demethylepipodophyllic acid (DMEPA) by Bacillus fusiformis CICC 20463.
Zhong, Jian-Jiang, Tang, Ya-Jie, Xu, Xiao-Ling, Tang, YJ   +3 more
core   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Biotransformation of Curcumin to Calebin-A: A Pharmacologically Important Novel Curcuminoid from Curcuma Species

, 2019
Calebin-A, a novel natural product of turmeric (Curcuma longa) rhizome has been reported to possess various pharmacological activities. The minimal natural occurrence has been the major constraint for exploiting its pharmacological use.
Anju Majeed, Muhammed Majeed, Furqan Ali, Kirankumar Beede, Nooruddin Thajuddin, Sivakumar Arumugam   +5 more
core   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source