Results 91 to 100 of about 7,408 (290)

VALIDATED LC-MS/MS METHOD FOR THE CONCOMITANT DETERMINATION OF AMOXICILLIN AND CLAVULANIC ACID FROM HUMAN PLASMA

Studia Universitatis Babes-Bolyai Chemia, 2017
The purpose of this study was the development and validation of an LC-MS/MS method, for the concomitant and rapid determination amoxicillin and clavulanic acid from human plasma. The sample workup involved a simple protein precipitation procedure.
József BALÁZSI, Csaba PAIZS, Florin-Dan IRIMIE, Monica Ioana TOŞA, László Csaba BENCZE, Róbert TŐTŐS   +5 more
doaj   +1 more source

Intensification of oxygen-dependent biotransformations catalyzed by immobilized enzymes

, 2021
CRUE-CSIC (Acuerdos Transformativos 2021)Oxidative biotransformations find a prominent role in the fine chemical industry and the valorization of renewable feedstocks.
Bolívar Bolívar, Juan Manuel, Ladero Galán, Miguel, Lorente Arévalo, Alvaro   +2 more
core   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Estudos de proteção da célula de saccharomyces cerevisiae para utilização em reações de redução em meio orgânico

Química Nova, 2002
New methodologies for protection of Saccharomyces cerevisiae (FP) cells when supported in montmorillonite K10 (K10), recovered or not with gelatin (G) and in the presence or absence of sucrose (S) are presented.
Nascimento Maria da Graça, Zanotto Sandra Patricia, Melegari Sílvia Pedroso, Moran Paulo J. S.   +3 more
doaj  

Plants in biotransformations

, 2012
U ovom je radu provedena asimetrična redukcija 3,4-dimetilacetofenona u 1-(3,4- dimetilfenil)etanol u vodi, kao „zelenom“ otapalu, pomoću biljaka: crvene leće (Lens culinaris), mungo graha (Vigna aureus) i bijelog graha (Phaseolus legument) kao „zelenim“
Pogačić, Ana-Marija
core  

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine

Drug Testing and Analysis, EarlyView.
This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC‐HRMS/MS identified four tentative metabolites; maximum urinary concentrations reached 4 ng/mL within 4–48 h.
O. Krug, A. Thomas, M. Thevis
wiley   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Waste to Hydrogen: Transforming Food Waste Into Biohythane (Bio‐H2 + Bio‐CH4) in a Two‐Stage Reactor With the Aid of a Metal‐Ion Catalyst

Energy Science &Engineering, EarlyView.
This study demonstrates a two‐stage catalytic bioreactor system that converts real food waste into high‐purity biohydrogen and biohythane. In Stage‐1, an enriched Clostridium thermocellum culture combined with Ni2+─Fe2+ bimetallic catalysis enhances hydrolysis efficiency and hydrogenase activity, resulting in a 77% increase in H2 yield and 75.8% purity
K. V. Sreedharan, Debabrata Barik, Ayyar Dinesh, D. Shanmugapriya, M. Santhamoorthy, N. Ashok   +5 more
wiley   +1 more source