Results 81 to 90 of about 11,278 (243)
Animal Research and One Health, EarlyView.Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin +6 more
wiley +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, EarlyView.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
Data-driven extraction of relative reasoning rules to limit combinatorial explosion in biodegradation pathway prediction [PDF]
, 2017 Motivation: The University of Minnesota Pathway Prediction System (UM-PPS) is a rule-based expert system to predict plausible biodegradation pathways for organic compounds. However, iterative application of these rules to generate biodegradation pathways
Ellis, Lynda +4 more
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Native proteins in organic chemistry. Recent achievements in the use of non hydrolytic enzymes for the synthesis of pharmaceuticals [PDF]
, 2016 Financial support by the Spanish Ministerio de Economia y Competitividad (MINECO) through the CTQ-2013-44153-P project is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente +2 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf +6 more
wiley +1 more source
Enhancing stress-resistance for efficient microbial biotransformations by synthetic biology
Frontiers in Bioengineering and Biotechnology, 2014 Chemical conversions mediated by microorganisms, otherwise known as microbial biotransformations, are playing an increasingly important role within the biotechnology industry.
Haiyang eJia +3 more
doaj +1 more source
Chemistry on the inside: green chemistry in mesoporous materials [PDF]
, 2000 An overview of the rapidly expanding area of tailored mesoporous solids is presented. The synthesis of a wide range of the materials is covered, both inorganically and organically modified.
Brunel D. +3 more
core +1 more source
Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity
British Journal of Clinical Pharmacology, EarlyView.Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa +5 more
wiley +1 more source
Studia Universitatis Babes-Bolyai Chemia, 2017 The purpose of this study was the development and validation of an LC-MS/MS method, for the concomitant and rapid determination amoxicillin and clavulanic acid from human plasma. The sample workup involved a simple protein precipitation procedure.
József BALÁZSI +5 more
doaj +1 more source
Biocatalysis. Biological systems for the production of chemicals [PDF]
, 2017 Biocatalysis harnesses the catalytic potential of enzymes to produce building blocks and end-products for the pharmaceutical and chemical industry. Located at the interface between fermentation processes and petrol-based chemistry, biotransformation ...
Held, M. +3 more
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