Results 81 to 90 of about 7,408 (290)

Three Enzyme-Catalyzed Redox Cascade for the Production of a Carvo-Lactone

, 2016
Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic ...
Oberleitner, Nikolin, Muschiol, Jan, Peters, Christin, Rudroff, Florian, Bornscheuer, Uwe T., Mihovilovic, Marko D.   +5 more
core  

Results of the screening biotransformations after three, five and seven days (according to GC).

, 2018
Results of the screening biotransformations after three, five and seven days (according to GC).
Marek Durajczyk (5233754), Tomasz Strzała (563229), Wanda Mączka (5233751), Katarzyna Wińska (5233748), Elżbieta Gębarowska (5233757), Małgorzata Grabarczyk (5233760)   +5 more
core   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Industrial multi-step biotransformations

, 2004
Biotransformations have moved far beyond the classic one-reaction approach. Progress in genomic science enables the rapid assembly of complex multi-enzyme catalysts that allow [i] utilizing cheaper starting materials, as in the case of 5-acetylneuraminic
Kümmel, A., Heinemann, M.; id_orcid, Panke, S., Schümperli, M.   +3 more
core   +1 more source

Redox Biocatalysis in Lidocaine‐Based Hydrophobic Deep Eutectic Solvents: Non‐Conventional Media Outperform Aqueous Conditions

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Two hydrophobic DESs, lidocaine/oleic acid and lidocaine/decanoic acid, were utilized as reaction media that were enzyme‐compatible and highly substrate‐solubilizer for carbonyl reduction catalyzed by horse liver alcohol dehydrogenase, focusing on the effect of water contents and on maximizing substrate loadings, which showcases for the first time the ...
Ningning Zhang, Viktoria Lahmann, Jan Philipp Bittner, Pablo Domínguez de María, Sven Jakobtorweihen, Irina Smirnova, Selin Kara   +6 more
wiley   +1 more source

Baeyer–Villiger Monooxygenases (BVMOs) as Biocatalysts

SynOpen, 2022
Chandrakant Sahu, Pooja A. Chawla
doaj   +1 more source

Arsenic as a pollutant of the environment: Origins, repartition, biotransformations and ecotoxicity [L'arsenic, polluant de l'environnement : Origines, distribution, biotransformations]

, 2000
International audienceThe arsenic speciation in the environment and the study of its biotransformations are actual research topics reported by numerous works. The aim of this present paper is to report a lot of recent selected research results concerning
Holeman, M., Pinel, R., Molenat, N.
core  

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Advantages of using biofilms to obtain high-value molecules by microbial biotransformations [PDF]

Exploration of Drug Science
Microbial biotransformations are valuable tools from “green chemistry” and involve converting parental molecules into new daughter ones with unique physical, chemical, or pharmacological properties.
Nicoly Subtil de Oliveira, Romeu Cassiano Pucci da Silva Ramos, Rafaela Caldas de Paula, Matheus Gonçalves da Costa Pereira, Rosimeire Takaki Rosa, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa   +6 more
doaj   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source