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Dissolving microdroplet electroanalysis enables attomolar-level detection.

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Nguyen JH, Rana A, Hatch SM, Dick JE.
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Biphasic dissolution combined with modified cylinder method—A new promising method for dissolution test in drug-loaded nanoemulsions

International Journal of Pharmaceutics, 2023
Dissolution testing is important in assessing the in vitro drug release performance for oral administration dosage forms. However, currently, a simple and efficient in vitro test to investigate critical factors that may impact the drug release and bioavailability at the development stage of a drug-loaded nanoemulsion (NE) is lacking.
Megumi Nishitani, Yukuyama, Jieyu, Zuo, Chulhun, Park, Malaz, Yousef, Mirla Anali Bazán, Henostroza, Gabriel Lima Barros, de Araujo, Nádia Araci, Bou-Chacra, Raimar, Löbenberg   +7 more
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Characterization and dissolution–reprecipitation behavior of biphasic tricalcium phosphate powders

Journal of Alloys and Compounds, 2011
Abstract α-tricalcium phosphate (α-TCP), biphasic α/β-tricalcium phosphate (α/β-TCP) with different two phase ratio and β-tricalcium phosphate (β-TCP) powders were prepared by calcining an amorphous calcium phosphate (ACP) precursor at a temperature ranging from 800 to 900 °C.
Chao Zou, Kui Cheng, Wenjian Weng, Chenlu Song, Piyi Du, Ge Shen, Gaorong Han   +6 more
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Dissolution of poorly water-soluble drugs in biphasic media using USP 4 and fiber optic system

Clinical Research and Regulatory Affairs, 2009
A novel in-vitro dissolution system based on the principle of flow-through technique has been designed to evaluate the in-vitro release rate of poorly water-soluble compounds.
Saroj Vangani, Xiaoling Li, Peter Zhou, Mary-Anne Del-Barrio, Rick Chiu, Nina Cauchon, Ping Gao, Cesar Medina, Bhaskara Jasti   +8 more
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The in vivo predictive dissolution for immediate release dosage of donepezil and danazol, BCS class IIc drugs, with the GIS and the USP II with biphasic dissolution apparatus

Journal of Drug Delivery Science and Technology, 2020
Abstract The formulation developments and the in vivo assessment of Biopharmaceutical Classification System (BCS) class II drugs are challenging due to their low solubility and high permeability in the human gastrointestinal (GI) tract. Since the pH change in the GI environment influences the drug dissolution of BCS class IIa and IIb drugs but not ...
Yasuhiro Tsume, Naoto Igawa, Adam J. Drelich, Hao Ruan, Gregory E. Amidon, Gordon L. Amidon   +5 more
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Development of a discriminative biphasic in vitro dissolution test and correlation with in vivo pharmacokinetic studies for differently formulated racecadotril granules

Journal of Controlled Release, 2017
The purpose of this study was to discriminate the release behavior from three differently formulated racecadotril (BCS II) granules and to establish an in vitro-in vivo correlation. Three granule formulations of the lipophilic drug were prepared with equivalent composition but prepared with different manufacturing processes (dry granulation, wet ...
Jia, Deng, Sven, Staufenbiel, Shilei, Hao, Bochu, Wang, Andriy, Dashevskiy, Roland, Bodmeier   +5 more
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Development of a biphasic dissolution test for Deferasirox dispersible tablets and its application in establishing an in vitro–in vivo correlation

European Journal of Pharmaceutics and Biopharmaceutics, 2016
In a biphasic dissolution medium, the integration of the in vitro dissolution of a drug in an aqueous phase and its subsequent partitioning into an organic phase is hypothesized to simulate the in vivo drug absorption. Such a methodology is expected to improve the probability of achieving a successful in vitro-in vivo correlation.
Amal, Al Durdunji, Hatim S, AlKhatib, Mutasim, Al-Ghazawi   +2 more
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Dissolution Behavior of Submicron Biphasic Tricalcium Phosphate Powders

Key Engineering Materials, 2006
Submicron α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP) and biphasic α/β-TCP powders were prepared by an amorphous calcium phosphate (ACP) precursor way. For the biphasic TCP powders, primary particle size was 300nm, α-TCP and β-TCP primary particles were homogeneously mixed in the submicron powders. When the TCP powders were soaked in
Rui Bing Wang, Wen Jian Weng, Xu Liang Deng, Kui Cheng, Xing Gang Liu, Pi Yi Du, Ge Shen, Gao Rong Han   +7 more
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Novel Biphasic In Vitro Dissolution Method Correctly Predicts the Oral Bioavailability of Curcumin in Humans

Journal of Agricultural and Food Chemistry, 2023
In vitro dissolution methods correctly predicting in vivo bioavailability of compounds from complex mixtures are lacking. We therefore used data on the in vivo performance of bioavailability-improved curcumin formulations to implement an in vivo predictive dissolution method (BiPHa+).
Marvin Benedikt Brenner, Sandra Flory, Matthias Wüst, Jan Frank, Karl Wagner   +4 more
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