Results 61 to 70 of about 20,585 (286)

A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome

eLife, 2019
The centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM).
Jérémy Magescas, Jenny C Zonka, Jessica L Feldman   +2 more
doaj   +1 more source

Bifunctional earth-abundant phosphate/phosphide catalysts prepared via atomic layer deposition for electrocatalytic water splitting [PDF]

, 2019
The development of active and stable earth-abundant catalysts for hydrogen and oxygen evolution is one of the requirements for successful production of solar fuels.
Dendooven, Jolien, Detavernier, Christophe, Dobbelaere, Thomas, Henderick, Lowie, Martens, Johan A, Minjauw, Matthias, Rongé, Jan, Sree, Sreeprasanth Pulinthanathu   +7 more
core   +2 more sources

The Combination of GIS and Biphasic to Better Predict In Vivo Dissolution of BCS Class IIb Drugs, Ketoconazole and Raloxifene [PDF]

Journal of Pharmaceutical Sciences, 2018
The formulation developments and the in vivo assessment of Biopharmaceutical Classification System (BCS) class II drugs are challenging due to their low solubility and high permeability in the human gastrointestinal (GI) tract. Since the GI environment influences the drug dissolution of BCS class II drugs, the human GI characteristics should be ...
Yasuhiro, Tsume, Naoto, Igawa, Adam J, Drelich, Gregory E, Amidon, Gordon L, Amidon   +4 more
openaire   +2 more sources

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Albumin Submicron Particles with Entrapped Riboflavin—Fabrication and Characterization

Nanomaterials, 2019
Although riboflavin (RF) belongs to the water-soluble vitamins of group B, its solubility is low. Therefore, the application of micro-formulations may help to overcome this limiting factor for the delivery of RF.
Nittiya Suwannasom, Kathrin Smuda, Chiraphat Kloypan, Waraporn Kaewprayoon, Nuttakorn Baisaeng, Ausanai Prapan, Saranya Chaiwaree, Radostina Georgieva, Hans Bäumler   +8 more
doaj   +1 more source

Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease [PDF]

, 2015
ACKNOWLEDGMENTS We thank patients and their caregivers for their participation in the study and are indebted to all the investigators involved in the study, particularly Drs. Douglas Fowlie and Donald Mowat for their helpful contributions to the clinical
Bentham, Peter, Harrington, Charles R, Kook, Karin A, Murray, Alison D, Staff, Roger T, Storey, John M D, Wischik, Claude M, Wischik, Damon J   +7 more
core   +1 more source

Toward Biorelevant Dissolution: Application of a Biphasic Dissolution Model as a Discriminating Tool for HPMC Matrices Containing a Model BCS Class II Drug

Dissolution Technologies, 2012
The potential of a biphasic dissolution system to assist with the analysis of controlled-release (CR), Biopharmaceutics Classification System (BCS) Class II pharmaceutical products has been investigated. Use of a biphasic dissolution medium (aqueous/octanol) provided sink conditions and afforded complete dissolution of nifedipine formulated in a CR ...
Daniel J. Phillips, Samuel R. Pygall, V. Brett Cooper, James C. Mann   +3 more
openaire   +1 more source

Receptor‐Free Identification of Toxic Gases Enabled by Hygroscopic Aqueous Salt Films

Advanced Functional Materials, EarlyView.
Water as a gas sensor coating sounds impossible—until it stops evaporating. Here, hygroscopic salt solutions (LiCl, LiBr, H3PO4) form non‐drying aqueous films on CNT chemiresistors under ambient air. Gases partition into these liquid layers, sometimes transforming into water, and generate salt‐specific resistance fingerprints across a four‐channel ...
Seongwoo Lee, Yun‐Tae Kim, Hwarang Choi, Sanghwan Park, Seongyeop Lim, Chang Young Lee   +5 more
wiley   +1 more source

Development of a gastroretentive delivery system for acyclovir by 3D printing technology and its in vivo pharmacokinetic evaluation in Beagle dogs.

PLoS ONE, 2019
Gastroretentive (GR) systems are designed to prolong gastric residence time to allow sustained absorption and improve the oral bioavailability of drugs with a narrow absorption window in the upper part of the gastrointestinal tract.
Soyoung Shin, Tae Hwan Kim, Seok Won Jeong, Seung Eun Chung, Da Young Lee, Do-Hyung Kim, Beom Soo Shin   +6 more
doaj   +1 more source

Microstructural evolution of joints with and without Sb, Ni in Sn58Bi solder under electro-thermal-force coupling

Journal of Materials Research and Technology, 2023
Severe atomic migration occurs in the solder under the effect of multi-physics field coupling, leading to serious reliability problems. Under the influence of multi-physics field coupling, severe atomic migration occurs in solder, resulting in ...
Xuefeng Wu, Zhuangzhuang Hou, Xiaochen Xie, Pengrong Lin, Yongjun Huo, Yong Wang, Xiuchen Zhao   +6 more
doaj   +1 more source