Results 201 to 210 of about 117,195 (298)

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann   +12 more
wiley   +1 more source

<i>In situ</i> interrogation of microorganisms mediating hydrocarbon degradation. [PDF]

open access: yesAppl Environ Microbiol
Ren X-Y   +8 more
europepmc   +1 more source

Microplastic Impacts on Seafood: A Global Synthesis of Experimental Findings

open access: yesFish and Fisheries, EarlyView.
ABSTRACT Plastic pollution is a growing global concern, with plastic and microplastic particles now widespread in aquatic environments. Microplastics are frequently ingested by marine organisms, including commercially important seafood species. Ingestion can lead to a range of biological effects, influenced by the size, type and quantity of plastic, as
Nina Wootton   +4 more
wiley   +1 more source

Occurrence of multiple congenital anomalies in Potamotrygon amandae (Elasmobranchii, Potamotrygoninae) embryos, including the first report of bicephaly

open access: yesJournal of Fish Biology, EarlyView.
Abstract Reports of teratogenic embryos in elasmobranchs have been documented in multiple species, with proposed aetiologies including environmental disturbances, genetic mutations, predation, exposure to endocrine‐disrupting compounds and maternal stress.
Douglas de Castro Ribeiro   +2 more
wiley   +1 more source

The targeted metabolomic profile of laticifers in rubber tree

open access: yesJournal of Integrative Plant Biology, EarlyView.
Targeted metabolomic profiling of rubber tree (Hevea brasiliensis) laticifers identified metabolites that were reprogramming by domestication, revealed active isoprenoid metabolism in the laticifers, and discovered loci with potential biosynthetic applications, supporting the potential of developing laticifers as bioreactors for production of valuable ...
Xiaomin Deng   +9 more
wiley   +1 more source

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