Results 271 to 280 of about 3,167,039 (375)

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann   +12 more
wiley   +1 more source

Prioritising research on endocrine disruption in the marine environment: a global perspective

open access: yesBiological Reviews, EarlyView.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto   +23 more
wiley   +1 more source

1-Hydroxy-1,8-napthyridinone (DHN) Analogs Potently Inhibit Monkeypox Virus Resolvase (Mpr). [PDF]

open access: yesJ Med Chem
Offei S   +8 more
europepmc   +1 more source

Root tip excision‐induced exodermis lignification impacts lateral root emergence in Brachypodium distachyon

open access: yesNew Phytologist, EarlyView.
Summary The mechanisms controlling lateral root emergence in monocots, particularly the role of the exodermis, are poorly understood. We investigated how natural variation in the Brachypodium distachyon stress response shapes root system architecture by modulating cell wall dynamics.
Kevin Bellande   +8 more
wiley   +1 more source

The effects of a (poly)phenol‐rich food intervention on markers of exercise‐induced inflammation and oxidative stress: A randomised controlled trial

open access: yesExperimental Physiology, EarlyView.
Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi   +5 more
wiley   +1 more source

Macrocyclic geminal diols: synthesis, structures, stability and photophysical properties. [PDF]

open access: yesChem Sci
Zou B   +10 more
europepmc   +1 more source

Atmospheric Deposition of Organic Pollutants: A Comprehensive Review of Sampling and Analytical Methodologies

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Atmospheric deposition of organic pollutants plays a crucial role in the transport and fate of contaminants in the environment, with implications for ecosystem health and human exposure. Persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and microplastics are increasingly recognized as transboundary threats due to ...
Iva Smoljo   +2 more
wiley   +1 more source

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