The nuclear receptor LXRα controls the functional specialization of splenic macrophages. [PDF]
, 2013 Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well
A-Gonzalez, Noelia +19 more
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How should a DEXA scan be used to evaluate bisphosphonate therapy for osteoporosis? [PDF]
, 2005 If bone density is evaluated after initiating bisphosphonate drug therapy, it should be tested no earlier than 2 years (strength of recommendation [SOR]: B, based on case series of dual energy x-ray absorptiometry [DEXA] scanning precision and ...
Easterling, Lisa +3 more
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Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis [PDF]
, 2013 Our objective was to evaluate the concentrations of serum 25-hydroxyvitamin D [25(OH)D], serum calcium, serum phosphorus, alkaline phosphatase, and parathormone (PTH) in patients with polyarticular juvenile idiopathic arthritis (JIA) and to associate ...
Hilario, Maria Odete Esteves +6 more
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Tc-99m-NTP 15-5 assessment of the early therapeutic response of chondrosarcoma to zoledronic acid in the Swarm rat orthotopic model [PDF]
, 2013 Background: Since proteoglycans (PGs) appear as key partners in chondrosarcoma biology, PG-targeted imaging using the radiotracer 99mTc-N-(triethylammonium)-3-propyl-[15]ane-N5 (99mTc-NTP 15-5) developed by our group was previously demonstrated to be a ...
Besse, S. +10 more
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Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress [PDF]
, 2016 WOS: 000374502300001PubMed ID: 27143852Background: Bisphosphonates, including zoledronate, target osteoclasts and are widely used in the treatment of osteoporosis and other bone resorption diseases, despite side effects that include damaging the stomach ...
Arun, Mehmet Zuhuri +6 more
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Molecular MedicineOsteoblasts are mainly derived from mesenchymal stem cells in the bone marrow. These stem cells can differentiate into osteoblasts, which have the functions of secreting bone matrix, promoting bone formation, and participating in bone remodeling.
Xiaohao Wang +4 more
doaj +1 more source
A CHRONIC PAIN PATIENT: MODERN DIAGNOSIS AND CONCEPT OF THERAPY [PDF]
, 2010 Ca. 80% der Patienten einer allgemeinmedizinischen Praxis suchen diese wegen ihrer Schmerzen auf. Der Anteil an Patienten mit chronischen Schmerzen liegt im deutschsprachigen Raum bei ca. 20%. Und der Anteil an akuten Schmerzen variiert, abhängig von der
Andreas Sandner-Kiesling +1 more
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The good and bad of targeting cancer-associated extracellular matrix [PDF]
, 2017 The maintenance of tissue homeostasis requires extracellular matrix (ECM) remodeling. Immune cells actively participate in regenerating damaged tissues contributing to ECM deposition and shaping.
Chiodoni, C. +3 more
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Tumor-Associated Macrophages: Therapeutic Targets for Skin Cancer [PDF]
, 2018 Tumor-associated macrophages (TAMs) and regulatory T cells (Tregs) are significant components of the microenvironment of solid tumors in the majority of cancers. TAMs sequentially develop from monocytes into functional macrophages.
Aiba Setsuya +5 more
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An Exploratory Analysis of Pharmaceutical Price Disparities and Their Implications Among Six Developed Nations [PDF]
, 2006 In our study of 43 drugs, prescription drug prices in several wealthy nations (Australia, Canada, France, Germany, and the U.K.) were much lower than in the U.S. on average, well below relative per capita GDP. There was relatively little difference among
Elizabeth DuPre +2 more
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