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Epidemiology and risk factors for bipolar disorder [PDF]

Therapeutic Advances in Psychopharmacology, 2018
Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential risk factors enables clinicians to identify patients who are more likely to develop bipolar disorder, which directs further investigation, follow up and caution
Marwaha, Steven, Rowland, Tobias
core   +2 more sources

Serum BDNF levels and state anxiety are associated with somatic symptoms in patients with panic disorder

Frontiers in Psychiatry, 2023
BackgroundWe aimed to explore the predictive role of serum BDNF and anxiety-related variables in changes in somatic symptoms post-escitalopram treatment in panic disorder (PD) patients.MethodsNinety PD patients and 99 healthy controls (HCs) were enrolled.
Jiaxin Li, Ru Li, Dazhi Li, Jian Zhang, Xingguang Luo, Yong Zhang   +5 more
doaj   +1 more source

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Nature Genetics, 2021
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci.
N. Mullins, A. Forstner, K. O’Connell, B. Coombes, J. Coleman, Zhen Qiao, T. Als, T. Bigdeli, S. Børte, J. Bryois, A. Charney, O. K. Drange, M. Gandal, S. Hagenaars, M. Ikeda, Nolan Kamitaki, Minsoo Kim, Kristi Krebs, Georgia Panagiotaropoulou, B. Schilder, Laura G. Sloofman, S. Steinberg, V. Trubetskoy, B. Winsvold, H. Won, L. Abramova, K. Adorjan, E. Agerbo, M. A. Al Eissa, D. Albani, N. Alliey-Rodriguez, A. Anjorin, V. Antilla, A. Antoniou, S. Awasthi, J. Baek, Marie Bækvad-Hansen, N. Bass, M. Bauer, E. Beins, Sarah E. Bergen, A. Birner, C. Bøcker Pedersen, E. Bøen, M. Boks, R. Bosch, M. Brum, B. Brumpton, N. Brunkhorst-Kanaan, M. Budde, J. Bybjerg-Grauholm, W. Byerley, M. Cairns, M. Casas, P. Cervantes, Toni‐Kim Clarke, C. Cruceanu, A. Cuellar-Barboza, J. Cunningham, D. Curtis, P. Czerski, A. Dale, N. Dalkner, F. David, F. Degenhardt, S. Djurovic, Amanda Dobbyn, A. Douzenis, T. Elvsåshagen, V. Escott-Price, I. Ferrier, A. Fiorentino, T. Foroud, L. Forty, J. Frank, O. Frei, N. Freimer, L. Frisén, K. Gade, J. Garnham, J. Gelernter, Marianne Giørtz Pedersen, I. Gizer, S. Gordon, K. Gordon-Smith, T. Greenwood, J. Grove, J. Guzmán-Parra, Kyooseob Ha, M. Haraldsson, M. Hautzinger, U. Heilbronner, D. Hellgren, S. Herms, P. Hoffmann, P. Holmans, L. Huckins, S. Jamain, Jessica S. Johnson, J. Kalman, Y. Kamatani, J. Kennedy, S. Kittel-Schneider, J. Knowles, M. Kogevinas, M. Koromina, T. Kranz, H. Kranzler, M. Kubo, R. Kupka, S. Kushner, C. Lavebratt, J. Lawrence, M. Leber, Heon-Jeong Lee, Phil H. Lee, S. Levy, Catrin E Lewis, C. Liao, S. Lucae, M. Lundberg, D. Macintyre, S. Magnusson, W. Maier, A. Maihofer, D. Malaspina, E. Maratou, Lina Martinsson, M. Mattheisen, S. Mccarroll, N. McGregor, P. McGuffin, J. Mckay, H. Medeiros, S. Medland, V. Millischer, G. Montgomery, J. Moran, D. Morris, Thomas W. Mühleisen, N. O’Brien, C. O’Donovan, Loes M. Olde Loohuis, L. Oruč, S. Papiol, A. Pardiñas, A. Perry, A. Pfennig, E. Porichi, J. Potash, D. Quested, T. Raj, M. Rapaport, J. R. DePaulo, E. J. Regeer, J. Rice, F. Rivas, M. Rivera, Julian Roth, P. Roussos, D. Ruderfer, C. Sánchez-Mora, E. Schulte, F. Senner, S. Sharp, P. Shilling, E. Sigurdsson, L. Sirignano, C. Slaney, O. Smeland, Danny J. Smith, J. Sobell, Christine Søholm Hansen, M. Soler Artigas, A. Spijker, Dan J Stein, J. Strauss, B. Świątkowska, C. Terao, T. Thorgeirsson, Claudio Toma, P. Tooney, Evangelia Eirini Tsermpini, M. Vawter, H. Vedder, J. Walters, S. Witt, S. Xi, Wei Xu, J. Yang, A. Young, Hannah Young, P. Zandi, Hang Zhou, Lea Zillich, R. Adolfsson, I. Agartz, M. Alda, L. Alfredsson, Gulja Babadjanova, L. Backlund, B. Baune, F. Bellivier, S. Bengesser, W. Berrettini, D. Blackwood, M. Boehnke, A. Børglum, G. Breen, V. Carr, S. Catts, A. Corvin, N. Craddock, U. Dannlowski, D. Dikeos, T. Esko, B. Étain, P. Ferentinos, M. Frye, J. Fullerton, M. Gawlik, E. Gershon, F. Goes, Melissa J. Green, M. Grigoroiu-Serbanescu, J. Hauser, F. Henskens, J. Hillert, K. Hong, D. Hougaard, C. Hultman, K. Hveem, N. Iwata, A. Jablensky, I. Jones, L. Jones, R. Kahn, J. Kelsoe, G. Kirov, M. Landén, M. Leboyer, C. Lewis, Qingqin S. Li, J. Lissowska, C. Lochner, C. Loughland, N. Martin, C. Mathews, F. Mayoral, S. McElroy, A. McIntosh, F. McMahon, I. Melle, P. Michie, L. Milani, P. Mitchell, G. Morken, O. Mors, P. Mortensen, B. Mowry, B. Müller-Myhsok, R. Myers, B. Neale, C. Nievergelt, M. Nordentoft, M. Nöthen, M. O’Donovan, K. Oedegaard, T. Olsson, M. Owen, S. Paciga, C. Pantelis, C. Pato, M. Pato, G. Patrinos, R. Perlis, D. Posthuma, J. Ramos-Quiroga, A. Reif, E. Reininghaus, M. Ribasés, M. Rietschel, S. Ripke, G. Rouleau, Takeo Saito, U. Schall, M. Schalling, P. Schofield, T. Schulze, L. Scott, R. Scott, A. Serretti, C. Shannon Weickert, J. Smoller, H. Stefánsson, K. Stefánsson, E. Stordal, F. Streit, P. Sullivan, G. Turecki, A. Vaaler, E. Vieta, J. Vincent, I. Waldman, T. Weickert, T. Werge, N. Wray, J. Zwart, J. Biernacka, J. Nurnberger, S. Cichon, H. Edenberg, E. Stahl, A. McQuillin, A. Di Florio, R. Ophoff, O. Andreassen   +316 more
semanticscholar   +1 more source

Diagnostic Stability of Primary Psychotic Disorders in a Research Sample

Frontiers in Psychiatry, 2021
Psychiatric diagnosis is often treated as a stable construct both clinically and in research; however, some evidence suggests that diagnostic change may be common, which may impact research validity and clinical care.
Andrea J. Wood, Amber R. Carroll, Ann K. Shinn, Ann K. Shinn, Dost Ongur, Dost Ongur, Kathryn E. Lewandowski, Kathryn E. Lewandowski   +7 more
doaj   +1 more source

A nationwide study on concordance with multimodal treatment guidelines in bipolar disorder [PDF]

, 2018
Background: Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities.
Hoogendoorn, Adriaan W., Kupka, Ralph W., Nolen, Willem A., Regeer, Eline J., Renes, Joannes W.   +4 more
core   +23 more sources

Structured physical exercise for bipolar depression: an open-label, proof-of concept study

International Journal of Bipolar Disorders, 2023
Background Physical exercise (PE) is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder.
Beny Lafer, Cicera Claudinea Duarte, Julia Maria D’Andrea Greve, Paulo Roberto dos Santos Silva, Karla Mathias de Almeida, Gabriel Okawa Belizario, Lucas Melo Neves   +6 more
doaj   +1 more source

Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth

Translational Psychiatry, 2023
There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies observed in youth bipolar disorder (BD). This study examined the association of a polygenic risk score for BD (BD-PRS) with grey matter structure and white matter ...
Xinyue Jiang, Clement C. Zai, Kody G. Kennedy, Yi Zou, Yuliya S. Nikolova, Daniel Felsky, L. Trevor Young, Bradley J. MacIntosh, Benjamin I. Goldstein   +8 more
doaj   +1 more source

Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions

NeuroImage: Clinical, 2021
Background: Auditory hallucinations (AH) are typically associated with schizophrenia (SZ), but they are also prevalent in bipolar disorder (BD). Despite the large body of research on the neural correlates of AH in SZ, the pathophysiology underlying AH ...
Melissa Hwang, Youkyung S. Roh, Jessica Talero, Bruce M. Cohen, Justin T. Baker, Roscoe O. Brady, Dost Öngür, Ann K. Shinn   +7 more
doaj   +1 more source

20-Year Trends in the Pharmacologic Treatment of Bipolar Disorder by Psychiatrists in Outpatient Care Settings.

American Journal of Psychiatry, 2020
OBJECTIVE Pharmacological options for treating bipolar disorder have increased over the past 20 years, with several second-generation antipsychotics receiving regulatory approval in the 1990s.
T. Rhee, M. Olfson, A. Nierenberg, S. Wilkinson   +3 more
semanticscholar   +1 more source

The functional impairment of different subtypes and occupational states in euthymic patients with bipolar disorder

BMC Psychiatry, 2021
Background The aim was to explore the associations between clinical symptoms, demographic variables, social and neurocognitive functioning in euthymic patients with bipolar disorder (BD) stratified by subgroups of DSM-IV BD (type I (BD-I) and type II (BD-
Xinyu Liu, Xiaojuan Ma, Wenchen Wang, Jian Zhang, Xia Sun, Xingguang Luo, Yong Zhang   +6 more
doaj   +1 more source