Results 131 to 140 of about 394,608 (327)
Advanced Science, EarlyView.The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu +10 more
wiley +1 more source
A case of bipolar disorder developing into atypical parkinsonism and presenting with frontotemporal asymmetrical brain degeneration. A TREDEM Registry Case Report [PDF]
, 2019 Maria Elena Di Battista +5 more
openalex +1 more source
Parabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
Advanced Science, EarlyView.Li‐ and V‐intercalated V2Se2O bilayers possess intralayer ferrimagnetic and interlayer ferromagnetic orders, alongside ferroelasticity, in‐plane uniaxial magnetic anisotropy, half‐metal/enhanced spin splitting, the anomalous Hall effect, giant magnetoresistance, tunneling magnetoresistance, near‐perfect spin filtering effect, spin Seebeck effect, and ...
Long Zhang +7 more
wiley +1 more source
Broadband All‐Optical Memtransistor Based on Organic Cocrystals for Noise‐Robust Motion Recognition
Advanced Science, EarlyView.This work presents an all‐optical synaptic transistor using DTT‐TCNQ organic charge transfer cocrystals, achieving broadband bidirectional modulation (395–808 nm) with highly linear synaptic plasticity (nonlinearity coefficients αp = 0.00191, αd = 0.00305).
Zhaohui Cai +8 more
wiley +1 more source
Efficient and Scalable Electrochemical Energy Systems via Peroxide‐Mediated Redox Chemistry
Advanced Science, EarlyView.We outline reaction mechanisms and catalyst strategies that enable efficient, reversible O2 ⇌ HO2– chemistry. Peroxide‐mediated pathways offer an alternative to the conventional 4e–/O2 route, improving round‐trip energy efficiency in rechargeable zinc–air batteries and supporting scalable hydrogen production without external storage or transportation ...
Alagar Raja Kottaichamy +3 more
wiley +1 more source
The genetic association between bipolar disorder and dementia: a qualitative review
Frontiers in PsychiatryBipolar disorder is a chronic disorder characterized by fluctuations in mood state and energy and recurrent episodes of mania/hypomania and depression. Bipolar disorder may be regarded as a neuro-progressive disorder in which repeated mood episodes may ...
Hirofumi Hirakawa, Takeshi Terao
doaj +1 more source
The effect of dialectical behavior therapy on executive function in patients with a bipolar disorder [PDF]
, 2018 Background: Bipolar disorder is a debilitating psychiatric disorder characterized by recurrent depression, manic and hippomanic episodes. The effect of a dialectical behavior therapy on executive functions in bipolar disorders has not been addressed so ...
Afshari, Behrooz +2 more
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